Human CAMP/LL37/FALL39 Antibody

CAMP (Cathelicidin AntiMicrobial Peptide; also18 kDa cationic antimicrobial protein, CAP18, LL37, FALL39 and HSD26) is a member of the cathelicidin family of proteins. It is widely expressed, being found associated with neutrophils, bronchial epithelium, renal tubule epithelium, activated keratinocytes,  gamma delta T cells, monocytes, NK cells, colonic epithelium and the stratum basale of nonkeratinized epithelium found in the vagina and oral cavity. CAMP has marked antimicrobial activity against both Gm+ and Gm- bacteria, and acts as a chemoattractant for neutrophils, monocytes and mast cells. CAMP is synthesized as 170 amino acid (aa) preproprecursor. It contains a 30 aa signal sequence, a 103 aa, 14 kDa prosegment (aa 31-131), and a 4-5 kDa, 37 aa (aa 134-170) C‑terminal mature fragment (LL37) or 39 aa (aa 132‑170) C‑terminal mature fragment (FALL39). In neutrophils, the 18-19 kDa proprecursor is stored in granules, where, upon activation, it is enzymatically cleaved and released. While both the prosegment and C‑terminal fragments possess antimicrobial activity, the prosegment also shows antiprotease activity, while the C‑terminal fragment also shows chemotactic activity. The prosegment may form homodimers, while the C‑terminal fragment (LL37) is reported to form homotetramers. Over aa 141-170, human CAMP shares only 50% and 57% aa sequence identity with mouse and rat CAMP, respectively.