Human CCR11 PE-conjugated Antibody

Catalog #: FAB6899P Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
FAB6899P-100

Detection of CCR11 in HEK293 Human Cell Line Transfected with Human CCR11 and eGFP by Flow Cytometry.

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Human CCR11 PE-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human CCR11 in direct ELISAs.

Source

Monoclonal Mouse IgM Clone # 674144

Purification

IgM-specific Affinity-purified from hybridoma culture supernatant

Immunogen

NS0 mouse myeloma cell line transfected with human CCR11
Accession # Q9NPB9

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Label

Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

10 µL/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of CCR11 in HEK293 Human Cell Line Transfected with Human CCR11 and eGFP by Flow Cytometry. HEK293 human embryonic kidney cell line transfected with either (A) human CCR11 or (B) irrelevant transfectants and eGFP was stained with Mouse Anti-Human CCR11 PE-conjugated Monoclonal Antibody (Catalog # FAB6899P). Quadrant markers were set based on control antibody staining (Catalog # IC105P). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: CCR11

CCR11, also known as CCRL1 and CCX-CKR, is a 45 kDa 7-transmembrane segment protein that is widely expressed on stromal cells. It is a silent receptor that does not induce intracellular calcium signaling, but instead serves as a chemokine scavenger receptor. CCR11 regulates dendritic cell and thymic precursor migration by mediating the clearance of the homeostatic chemokines CCL19, 21, and 25. It is upregulated on some breast cancer cells and on bronchial epithelial cells in pulmonary sarcoidosis. Human CCR11 shares 85% amino acid sequence identity with mouse and rat CCR11.

Entrez Gene IDs

51554 (Human); 252837 (Mouse); 685243 (Rat)

Alternate Names

ACKR4; CC chemokine receptor-like 1; C-C CKR-11; CCBP2CCX CKR; CC-CKR-11; CCR11; CCR11CCR10; CCRL1; CCX-CKR; chemokine (C-C motif) receptor-like 1; orphan seven-transmembrane receptor, chemokine related; PPR1; PPR1cc motif, receptor-like protein 1; VSHK1; VSHK1CKR-11