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Human CD14 Quantikine ELISA Kit

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Human CD14 ELISA Standard Curve
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Summary Sample Values Precision Recovery Linearity Data Examples Product Datasheets Preparation and Storage Background Related Research Areas

Human CD14 Quantikine ELISA Kit Summary

Assay Type
Solid Phase Sandwich ELISA
Format
96-well strip plate
Assay Length
4.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (100 uL), Serum (10 uL), EDTA Plasma (10 uL), Heparin Plasma (10 uL), Citrate Plasma (10 uL)
Sensitivity
125 pg/mL
Assay Range
250.0 - 16,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma)
Specificity
Natural and recombinant human sCD14
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Sample Values

Serum/Plasma - Samples from apparently healthy volunteers were evaluated for the presence of human CD14 in this assay. No medical histories were available for the donors used in this study.

Sample TypeMean (ng/mL)Range (ng/mL)
Serum (n=66)1900800-3200
EDTA plasma (n=34)18001200-2600
Heparin plasma (n=34)19001200-3100
Citrate plasma (n=34)20001500-3000

Cell Culture Supernates - - Human peripheral blood mononuclear cells (5 x 106 cells/mL) were cultured in RPMI supplemented with 5% fetal bovine serum, 50 μM beta -mercaptoethanol, 2 mM L-glutamine, 100 U/mL penicillin, and 100 μg/mL streptomycin sulfate. The cells were cultured unstimulated or stimulated with 10 μg/mL PHA. Aliquots of the cell culture supernates were removed on days 1, 3, and 5 and assayed for levels of human CD14.

Sample TypeDay 1 (pg/mL)Day 3 (pg/mL)Day 5 (pg/mL)
Unstimulated507094577762
Stimulated12,28722,34324,720



Product Summary

The Quantikine Human soluble CD14 Immunoassay is a 4.5 hour solid phase ELISA designed to measure human soluble CD14 in cell culture supernates, serum, and plasma. It contains recombinant human CD14 expressed from CHO cells and antibodies raised against the recombinant factor. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained measuring natural human sCD14 showed dose-response curves that were parallel to the standard curves obtained using the kit standards. These results indicate that this kit can be used to determine relative mass values for natural human sCD14.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 40 40 40
Mean (pg/mL) 1111 2158 4187 1159 2298 4346
Standard Deviation 71 104 216 86 153 209
CV% 6.4 4.8 5.2 7.4 6.7 4.8

Recovery

The recovery of sCD14 spiked to three different levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Media (n=5) 91 85-105
Citrate Plasma (n=5) 102 88-110
EDTA Plasma (n=5) 98 90-107
Heparin Plasma (n=5) 96 91-104
Serum (n=5) 98 84-107

Linearity

To assess the linearity of the assay, five samples containing or spiked with high concentrations of sCD14 were diluted with Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Human CD14 ELISA Linearity

Scientific Data

N/A Human CD14 ELISA Standard Curve View Larger

Human CD14 ELISA Standard Curve

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: CD14

CD14 is a glycoprotein that mediates the interaction of lipopolysaccharide (LPS, endotoxin)with cells, thereby signaling the presence of gram-negative bacteria (1-3). CD14 is eithersoluble (CD14) (4, 5) or membrane-bound (mCD14) by a glycosylphosphatidylinositol (GPI)anchor (6, 7). mCD14 is a 55 kDa glycoprotein (1), while CD14 varies from about 43 to 53 kDa,depending on the degree of glycosylation and whether it was synthesized without the anchoror was shed by phospholipase cleavage of the anchor or by proteolysis (12-14). There is noevidence for different mRNAs for m- and CD14. There is no apparent sequence homology withother proteins. The sequence of human CD14 is 63-73% identical to that of mouse, rat, or rabbitCD14 (15).

mCD14 is expressed primarily on myeloid cells, such as monocytes, macrophages andneutrophils (1-3), the cells most sensitive to LPS, and to a lesser extent on other cells, such as Bcells (8) and a circulating dendritic cell progenitor (9). CD14 appears to mediate LPS stimulationof cells that do not express mCD14 (10, 11), such as endothelial, epithelial and smooth-musclecells. CD14 is found in both serum and urine (5).
The binding of LPS to CD14 requires an acute phase protein, LPS-binding protein (LBP) (16).The relationship of mCD14, CD14, LPS and LBP is complicated. At low concentrations of LPS,LBP is essential for the binding of LPS to CD14, but at high concentrations, LBP may actuallyinhibit binding of LPS to CD14. In addition, CD14 may compete with mCD14 for LPS (17) andmay serve to help clear LPS (18). These four factors thus appear to participate in a complexfeedback mechanism of immune regulation involving both up-regulation and down-regulationof the inflammatory process triggered by LPS. It is loss of control of this mechanism thatappears to lead to septic shock. LPS-bound CD14 signals production of inflammatory cytokinesand other inflammatory proteins, but the mechanism of signal transduction is unclear. Sincea GPI anchor is not transmembrane, there presumably is another transmembrane protein oncells through which LPS-bound CD14 transmits a signal (19).
In addition to its well known role in gram-negative infections, CD14 likely serves otherfunctions as well. It recognizes soluble peptidylglycan from gram-positive cell walls (20), and ithas been reported to bind apoptotic cells and induce their phagocytosis (21).

Entrez Gene IDs:
929 (Human); 12475 (Mouse); 60350 (Rat); 100037938 (Porcine)
Alternate Names:
CD14 antigen; CD14 molecule; CD14; monocyte differentiation antigen CD14; Myeloid cell-specific leucine-rich glycoprotein
&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Assay Procedure

Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.
    3. 100 µL Assay Diluent
  3.   Add 100 µL of Assay Diluent to each well.
    4. 100 µL Standard, Control, or Sample
  4.   Add 100 µL of Standard, control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 3 hours.
  5.   Aspirate each well and wash, repeating the process 3 times for a total of 4 washes.
    6. 200 µL Conjugate
  6.   Add 200 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 1 hour.
  7.   Aspirate and wash 4 times.
    8. 200 µL Substrate Solution
  8.   Add 200 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.
    9. 50 µL Stop Solution
  9.   Add 50 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.

Citations for Human CD14 Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

140 Citations: Showing 1 - 10
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  1. Elevated intestinal fatty acid-binding protein levels as a marker of portal hypertension and gastroesophageal varices in cirrhosis
    Authors: Miuma, S;Miyaaki, H;Taura, N;Kanda, Y;Matsuo, S;Tajima, K;Takahashi, K;Nakao, Y;Fukushima, M;Haraguchi, M;Sasaki, R;Ozawa, E;Ichikawa, T;Nakao, K;
    Scientific reports
    Species: Human
    Sample Types: Serum
  2. Inflammatory Biomarker Reduction With Fostemsavir Over 96 Weeks in Heavily Treatment-Experienced Adults With Multidrug-Resistant HIV-1 in the BRIGHTE Study
    Authors: Clark, A;Prakash, M;Chabria, S;Pierce, A;Castillo-Mancilla, JR;Wang, M;Du, F;Tenorio, AR;
    Open forum infectious diseases
    Species: Human
    Sample Types: Serum, Plasma
  3. Inflammation and cytomegalovirus viremia during pregnancy drive sex-differentiated differences in mortality and immune development in HIV-exposed infants
    Authors: Evans, C;Mutasa, K;Rukobo, S;Govha, M;Mushayanembwa, P;Chasekwa, B;Majo, FD;Tavengwa, NV;Broad, J;Noble, C;Gough, EK;Kelly, P;Bourke, CD;Humphrey, JH;Ntozini, R;Prendergast, AJ;
    Nature communications
    Species: Human
    Sample Types: Plasma
  4. HIV-associated gut microbial alterations are dependent on host and geographic context
    Authors: Rocafort, M;Gootenberg, DB;Luévano, JM;Paer, JM;Hayward, MR;Bramante, JT;Ghebremichael, MS;Xu, J;Rogers, ZH;Munoz, AR;Okello, S;Kim, JH;Sentongo, R;Wagubi, R;Lankowski, A;Maruapula, S;Zhao, G;Handley, SA;Mosepele, M;Siedner, MJ;Kwon, DS;
    Nature communications
    Species: Human
    Sample Types: Plasma
  5. Disrupted balance between pro-inflammatory lipid mediators and anti-inflammatory specialized pro-resolving mediators is linked to hyperinflammation in patients with alcoholic hepatitis
    Authors: Li, W;Xia, Y;Yang, J;Sanyal, AJ;Shah, VH;Chalasani, NP;Yu, Q;
    medRxiv : the preprint server for health sciences
    Species: Human
    Sample Types: Plasma
  6. Design and Fabrication of a 3D-Printed Microfluidic Immunoarray for Ultrasensitive Multiplexed Protein Detection
    Authors: Hiniduma, K;Bhalerao, KS;De Silva, PIT;Chen, T;Rusling, JF;
    Micromachines
    Species: Human
    Sample Types: Protein, Serum
  7. HIV-1 treatment timing shapes the human intestinal memory B-cell repertoire to commensal bacteria
    Authors: Planchais, C;Molinos-Albert, LM;Rosenbaum, P;Hieu, T;Kanyavuz, A;Clermont, D;Prazuck, T;Lefrou, L;Dimitrov, JD;Hüe, S;Hocqueloux, L;Mouquet, H;
    Nature communications
    Species: Human
    Sample Types: Cell Culture Supernates
  8. Proton pump inhibitor treatment aggravates bacterial translocation in patients with advanced cirrhosis and portal hypertension
    Authors: Sturm, L;Hirose, M;Stolz, L;Schultheiss, M;Zoldan, K;Reincke, M;Huber, JP;Kaeser, R;Boettler, T;Thimme, R;Albert, E;Busch, H;Künstner, A;Bettinger, D;
    mBio
    Species: Human
    Sample Types: Plasma
  9. Milk-Fat-Globule-Membrane-Enriched Dairy Milk Compared with a Soy-Lecithin-Enriched Beverage Did Not Adversely Affect Endotoxemia or Biomarkers of Gut Barrier Function and Cardiometabolic Risk in Adults with Metabolic Syndrome: A Randomized Controlled Crossover Trial
    Authors: Pokala, A;Quarles, WR;Ortega-Anaya, J;Jimenez-Flores, R;Cao, S;Zeng, M;Hodges, JK;Bruno, RS;
    Nutrients
    Species: Human
    Sample Types: Serum
  10. Psychological stress is associated with arterial inflammation in people living with treated HIV infection
    Authors: Chow, FC;Mundada, NS;Abohashem, S;La Joie, R;Iaccarino, L;Arechiga, VM;Swaminathan, S;Rabinovici, GD;Epel, ES;Tawakol, A;Hsue, PY;
    Brain, behavior, and immunity
    Species: Human
    Sample Types: Plasma
  11. Phase 2, randomized, double-blind, placebo-controlled multi-center trial of the clinical and biological effects of anti-CD14 treatment in hospitalized patients with COVID-19 pneumonia
    Authors: Mabrey, FL;Nian, H;Yu, C;Barnes, EM;Malhotra, U;Mikacenic, C;Goldstein, J;O'Mahony, DS;Garcia-Diaz, J;Finn, P;Voelker, K;Morrell, ED;Self, WH;Becker, PM;Martin, TR;Wurfel, MM;
    EBioMedicine
    Species: Human
    Sample Types: Serum
  12. Prolonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys
    Authors: Q Le Hingrat, P Sette, C Xu, AR Rahmberg, L Tarnus, H Annapuredd, A Kleinman, E Brocca-Cof, R Sivanandha, S Sivanandha, T He, DJ Capreri, D Ma, JD Estes, JM Brenchley, C Apetrei, I Pandrea
    Nature Communications, 2023-02-22;14(1):979.
    Species: Primate - Chlorocebus sabaeus (Green Monkey)
    Sample Types: Plasma
  13. Rebound HIV-1 in cerebrospinal fluid after antiviral therapy interruption is mainly clonally amplified R5 T cell-tropic virus
    Authors: LP Kincer, SB Joseph, MM Gilleece, BM Hauser, S Sizemore, S Zhou, C Di Germani, H Zetterberg, D Fuchs, SG Deeks, S Spudich, M Gisslen, RW Price, R Swanstrom
    Nature Microbiology, 2023-01-30;8(2):260-271.
    Species: Human
    Sample Types: CSF
  14. Cerebrovascular pulsatility index is higher in chronic kidney disease
    Authors: ES Oh, KA Freeberg, CN Steele, W Wang, H Farmer-Bai, ME Coppock, DR Seals, M Chonchol, MJ Rossman, DH Craighead, KL Nowak
    Physiological Reports, 2023-01-01;11(1):e15561.
    Species: Human
    Sample Types: Serum
  15. Longitudinal multi-omics analyses of the gut-liver axis reveals metabolic dysregulation in hepatitis C infection and cirrhosis
    Authors: RO Ali, GM Quinn, R Umarova, JA Haddad, GY Zhang, EC Townsend, L Scheuing, KL Hill, M Gewirtz, S Rampertaap, SD Rosenzweig, AT Remaley, JM Han, V Periwal, H Cai, PJ Walter, C Koh, EB Levy, DE Kleiner, O Etzion, T Heller
    Nature Microbiology, 2022-12-15;0(0):.
    Species: Human
    Sample Types: Serum
  16. Long-Term Associations between Human Cytomegalovirus Antibody Levels with All-Cause Mortality and Cardiovascular Outcomes in an Australian Community-Based Cohort
    Authors: S Lee, N van den Be, A Castley, M Divitini, M Knuiman, P Price, D Nolan, F Sanfilippo, G Dwivedi
    Viruses, 2022-11-29;14(12):.
    Species: Human
    Sample Types: Serum
  17. The biological activity of serum bacterial lipopolysaccharides associates with disease activity and likelihood of achieving remission in patients with rheumatoid arthritis
    Authors: J Parantaine, G Barreto, R Koivuniemi, H Kautiainen, D Nordström, E Moilanen, M Hämäläinen, M Leirisalo-, K Nurmi, KK Eklund
    Arthritis Research & Therapy, 2022-11-21;24(1):256.
    Species: Human
    Sample Types: Serum
  18. Longitudinal Assessment of Multiple Immunological and Inflammatory Parameters during Successful DAA Therapy in HCV Monoinfected and HIV/HCV Coinfected Subjects
    Authors: P Zuccalà, T Latronico, R Marocco, S Savinelli, S Vita, F Mengoni, T Tieghi, C Borgo, B Kertusha, A Carraro, G D'Ettorre, V Vullo, CM Mastroiann, GM Liuzzi, M Lichtner
    International Journal of Molecular Sciences, 2022-10-08;23(19):.
    Species: Human
    Sample Types: Plasma
  19. Circulating biomarker correlates of left atrial size and myocardial extracellular volume fraction among persons living with and without HIV
    Authors: TE Peterson, C Landon, SA Haberlen, F Bhondoekha, MW Plankey, FJ Palella, DA Piggott, JB Margolick, TT Brown, WS Post, KC Wu
    BMC cardiovascular disorders, 2022-09-03;22(1):393.
    Species: Human
    Sample Types: Serum
  20. The role of CD101-expressing CD4 T cells in HIV/SIV pathogenesis and persistence
    Authors: Z Strongin, TN Hoang, GK Tharp, AR Rahmberg, JL Harper, K Nguyen, L Franchitti, B Cervasi, M Lee, Z Zhang, EA Boritz, G Silvestri, VC Marconi, SE Bosinger, JM Brenchley, DA Kulpa, M Paiardini
    PloS Pathogens, 2022-07-22;18(7):e1010723.
    Species: Human
    Sample Types: Plasma
  21. Vascular Calcification and the Gut and Blood Microbiome in Chronic Kidney Disease Patients on Peritoneal Dialysis: A Pilot Study
    Authors: A Merino-Rib, R Araujo, L Pereira, J Campos, L Barreiros, MA Segundo, N Silva, CFFA Costa, J Quelhas-Sa, F Trindade, I Falcão-Pir, I Alencastre, IB Dumitrescu, B Sampaio-Ma
    Biomolecules, 2022-06-21;12(7):.
    Species: Human
    Sample Types: Plasma
  22. Impact of illicit opioid use on markers of monocyte activation and systemic inflammation in people living with HIV
    Authors: A Kholodnaia, K So-Armah, D Cheng, N Gnatienko, G Patts, JH Samet, M Freiberg, D Lioznov
    PLoS ONE, 2022-05-05;17(5):e0265504.
    Species: Human
    Sample Types: Serum
  23. Inflammatory Markers after Switching to a Dual Drug Regimen in HIV-Infected Subjects: A Two-Year Follow-Up
    Authors: M Vassallo, J Durant, R Fabre, L Lotte, A Sindt, A Puchois, A De Monte, R Cezar, P Corbeau, C Pradier
    Viruses, 2022-04-28;14(5):.
    Species: Human
    Sample Types: Plasma
  24. Liver alterations are not improved by inulin supplementation in alcohol use disorder patients during alcohol withdrawal: A pilot randomized, double-blind, placebo-controlled study
    Authors: C Amadieu, L Maccioni, S Leclercq, AM Neyrinck, NM Delzenne, P de Timary, P Stärkel
    EBioMedicine, 2022-04-28;80(0):104033.
    Species: Human
    Sample Types: Plasma
  25. Maternal breast milk microbiota and immune markers in relation to subsequent development of celiac disease in offspring
    Authors: J Štšepetova, K Simre, A Tagoma, O Uibo, A Peet, H Siljander, V Tillmann, M Knip, R Mändar, R Uibo
    Scientific Reports, 2022-04-22;12(1):6607.
    Species: Human
    Sample Types: Breast Milk
  26. Immune Activation in Primary Human Immunodeficiency Virus: Influence of Duration of Infection, Treatment, and Substance Use
    Authors: T Gilada, SR Schnittman, E White, J Mercader, Y Wang, S Dasgupta, R Valdez, D Pinto-Sant, S Pasalar, J Sanchez, P Gonzales, JR Lama, R Bender Ign, A Duerr
    Open forum infectious diseases, 2022-03-24;9(6):ofac155.
    Species: Human
    Sample Types: Plasma
  27. Blood-brain barrier and gut barrier dysfunction in chronic kidney disease with a focus on circulating biomarkers and tight junction proteins
    Authors: L Hernandez, LJ Ward, S Arefin, T Ebert, A Laucyte-Ci, GOING-FWD, O Heimbürger, P Barany, L Wennberg, P Stenvinkel, K Kublickien
    Scientific Reports, 2022-03-15;12(1):4414.
    Species: Human
    Sample Types: Serum
  28. Targeting the Gut Microbiota of Vertically HIV-Infected Children to Decrease Inflammation and Immunoactivation: A Pilot Clinical Trial
    Authors: T Sainz, L Diaz, D Rojo, MI Clemente, C Barbas, MJ Gosalbes, N Jimenez-He, L Escosa, S Guillen, JT Ramos, MÁ Muñoz-Fern, ML Navarro, MJ Mellado, S Serrano-Vi
    Nutrients, 2022-02-26;14(5):.
    Species: Human
    Sample Types: Plasma
  29. Maternal inflammatory and omega-3 fatty acid pathways mediate the association between socioeconomic disadvantage and childhood cognition
    Authors: W Marx, S Thomson, M O'Hely, C Symeonides, F Collier, MLK Tang, A Loughman, D Burgner, R Saffery, C Pham, T Mansell, PD Sly, P Vuillermin, S Ranganatha, AL Ponsonby, Barwon Inf
    Brain, Behavior, and Immunity, 2021-12-08;100(0):211-218.
    Species: Human
    Sample Types: Serum
  30. Translocating lipopolysaccharide correlates with the severity of enterovirus A71-induced HFMD by promoting pro-inflammation and viral IRES activity
    Authors: Y Wang, K Dan, X Xue, X Yang, X Feng, Q Yang, J Yang, B Chen
    Gut pathogens, 2021-11-22;13(1):69.
    Species: Human
    Sample Types: Serum
  31. Biomarkers of disease severity in patients with visceral leishmaniasis co-infected with HIV
    Authors: GR Ferreira, JR Santos-Oli, ML Silva-Frei, M Honda, DL Costa, AM Da-Cruz, CHN Costa
    Cytokine, 2021-10-27;149(0):155747.
    Species: Human
    Sample Types: Serum
  32. Dysbiosis of Gut Microbiota Promotes Hepatocellular Carcinoma Progression by Regulating the Immune Response
    Authors: N Zhang, Y Gou, S Liang, N Chen, Y Liu, Q He, J Zhang
    Journal of Immunology Research, 2021-10-20;2021(0):4973589.
    Species: Human
    Sample Types: Plasma
  33. A matrix metalloproteinase-generated neoepitope of CRP can identify knee and multi-joint inflammation in osteoarthritis
    Authors: LC Alexander, G McHorse, JL Huebner, AC Bay-Jensen, MA Karsdal, VB Kraus
    Arthritis Research & Therapy, 2021-08-31;23(1):226.
    Species: Human
    Sample Types: Plasma
  34. Long-term SARS-CoV-2-specific immune and inflammatory responses in individuals recovering from COVID-19 with and without post-acute symptoms
    Authors: MJ Peluso, AN Deitchman, L Torres, NS Iyer, SE Munter, CC Nixon, J Donatelli, C Thanh, S Takahashi, J Hakim, K Turcios, O Janson, R Hoh, V Tai, Y Hernandez, EA Fehrman, MA Spinelli, M Gandhi, L Trinh, T Wrin, CJ Petropoulo, FT Aweeka, I Rodriguez-, JD Kelly, JN Martin, SG Deeks, B Greenhouse, RL Rutishause, TJ Henrich
    Cell Reports, 2021-08-06;36(6):109518.
    Species: Human
    Sample Types: Serum
  35. Soluble cluster of differentiation 14 levels elevated in bile from gallbladder cancer cases from Shanghai, China
    Authors: VL Brun, AF Corbel, AW Hsing, TJ Kemp, AL Van Dyke, A Hildesheim, B Zhu, YT Gao, LA Pinto, J Koshiol
    Scientific Reports, 2021-06-28;11(1):13405.
    Species: Human
    Sample Types: Bile
  36. Rapid progression is associated with lymphoid follicle dysfunction in SIV-infected infant rhesus macaques
    Authors: MP Wood, CI Jones, A Lippy, BG Oliver, B Walund, KA Fancher, BS Fisher, PJ Wright, JT Fuller, P Murapa, J Habib, M Mavigner, A Chahroudi, DN Sather, DH Fuller, DL Sodora
    PloS Pathogens, 2021-05-07;17(5):e1009575.
    Species: Human
    Sample Types: Plasma
  37. Inflammatory Markers During Early Treatment of Seroconverters in a Randomized Placebo-Controlled Trial of PrEP (ANRS-IPERGAY)
    Authors: S Chawki, I Charreau, A Gabassi, D Carette, E Cua, L Cotte, G Pialoux, C Pintado, L Meyer, ML Chaix, C Delaugerre, JM Molina
    Open forum infectious diseases, 2021-03-20;8(3):ofab085.
    Species: Human
    Sample Types: Plasma
  38. B cell and monocyte phenotyping: A quick asset to investigate the immune status in patients with IgA nephropathy
    Authors: S Sendic, L Mansouri, S Lundberg, A Nopp, SH Jacobson, J Lundahl
    PLoS ONE, 2021-03-19;16(3):e0248056.
    Species: Human
    Sample Types: Plasma
  39. Insomnia symptoms and biomarkers of monocyte activation, systemic inflammation, and coagulation in HIV: Veterans Aging Cohort Study
    Authors: BM Polanka, S Kundu, KA So-Armah, MS Freiberg, SK Gupta, TCB Zapolski, AT Hirsh, RJ Bedimo, MJ Budoff, AA Butt, CH Chang, SS Gottlieb, VC Marconi, JA Womack, JC Stewart
    PLoS ONE, 2021-02-09;16(2):e0246073.
    Species: Human
    Sample Types: Serum
  40. Identifying a biological signature of prenatal maternal stress
    Authors: JM Keane, AS Khashan, FP McCarthy, LC Kenny, JM Collins, SM O'Donovan, JR Brown, JF Cryan, TG Dinan, G Clarke, SM O'Mahony
    JCI Insight, 2021-01-25;0(0):.
    Species: Human
    Sample Types: Serum
  41. Identification of distinct immune activation profiles in adult humans
    Authors: R Cezar, A Winter, D Desigaud, M Pastore, L Kundura, AM Dupuy, C Cognot, T Vincent, C Reynes, C Dunyach-Re, JP Lavigne, R Sabatier, P Le Merre, E Maggia, P Corbeau
    Scientific Reports, 2020-11-30;10(1):20824.
    Species: Human
    Sample Types: Plasma
  42. The Differences between Gluten Sensitivity, Intestinal Biomarkers and Immune Biomarkers in Patients with First-Episode and Chronic Schizophrenia
    Authors: M Dzikowski, D Juchnowicz, I Dzikowska, J Rog, M Próchnicki, M Kozio?, H Karakula-J
    J Clin Med, 2020-11-18;9(11):.
    Species: Human
    Sample Types: Serum
  43. Endotoxemia coupled with heightened inflammation predicts future depressive symptoms
    Authors: AA Madison, R Andridge, AC Padin, S Wilson, MT Bailey, CM Alfano, SP Povoski, AM Lipari, DM Agnese, WE Carson, WB Malarkey, JK Kiecolt-Gl
    Psychoneuroendocrinology, 2020-10-08;122(0):104864.
    Species: Human
    Sample Types: Serum
  44. Elevated acute phase proteins reflect peripheral inflammation and disease severity in patients with amyotrophic lateral sclerosis
    Authors: DR Beers, W Zhao, DW Neal, JR Thonhoff, AD Thome, A Faridar, S Wen, J Wang, SH Appel
    Scientific Reports, 2020-09-17;10(1):15295.
    Species: Human
    Sample Types: Serum
  45. Interferon-alpha alters host glycosylation machinery during treated HIV infection
    Authors: LB Giron, F Colomb, E Papasavvas, L Azzoni, X Yin, M Fair, A Anzurez, M Damra, K Mounzer, JR Kostman, P Tebas, U O'Doherty, H Tateno, Q Liu, MR Betts, LJ Montaner, M Abdel-Mohs
    EBioMedicine, 2020-08-19;59(0):102945.
    Species: Human
    Sample Types: Plasma
  46. Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma
    Authors: SP Polster, A Sharma, C Tanes, AT Tang, P Mericko, Y Cao, J Carrión-Pe, R Girard, J Koskimäki, D Zhang, A Stadnik, SG Romanos, SB Lyne, R Shenkar, K Yan, C Lee, A Akers, L Morrison, M Robinson, A Zafar, K Bittinger, H Kim, JA Gilbert, ML Kahn, L Shen, IA Awad
    Nat Commun, 2020-05-27;11(1):2659.
    Species: Human
    Sample Types: Plasma
  47. Statin therapy is associated with lower prevalence of gut microbiota dysbiosis
    Authors: S Vieira-Sil, G Falony, E Belda, T Nielsen, J Aron-Wisne, R Chakaroun, SK Forslund, K Assmann, M Valles-Col, TTD Nguyen, S Proost, E Prifti, V Tremaroli, N Pons, E Le Chateli, F Andreelli, JP Bastard, LP Coelho, N Galleron, TH Hansen, JS Hulot, C Lewinter, HK Pedersen, B Quinquis, C Rouault, H Roume, JE Salem, NB Søndertoft, S Touch, ME Dumas, SD Ehrlich, P Galan, JP Gøtze, T Hansen, JJ Holst, L Køber, I Letunic, J Nielsen, JM Oppert, M Stumvoll, H Vestergaar, JD Zucker, P Bork, O Pedersen, F Bäckhed, K Clément, J Raes
    Nature, 2020-05-06;581(7808):310-315.
    Species: Human
    Sample Types: Serum
  48. Th22 cells are efficiently recruited in the gut by CCL28 as an alternative to CCL20 but do not compensate for the loss of Th17 cells in treated HIV-1-infected individuals
    Authors: M Nayrac, M Requena, C Loiseau, M Cazabat, B Suc, N Carrere, K Barange, L Alric, G Martin-Blo, J Izopet, P Delobel
    Mucosal Immunol, 2020-04-28;0(0):.
    Species: Human
    Sample Types: Plasma
  49. Biomarkers of Cellular Stress Do Not Associate with sCD14 in Progressive HIV and SIV Infections in Vivo
    Authors: CL Vinton, CE Starke, AM Ortiz, SH Lai, JK Flynn, O Sortino, K Knox, I Sereti, JM Brenchley
    Pathog Immun, 2020-04-24;5(1):68-88.
    Species: Human, Rhesus Macaca (Macaque)
    Sample Types: Plasma
  50. Sialylation and fucosylation modulate inflammasome-activating eIF2 Signaling and microbial translocation during HIV infection
    Authors: LB Giron, CE Tanes, MH Schleimann, PA Engen, LM Mattei, A Anzurez, M Damra, H Zhang, K Bittinger, F Bushman, A Kossenkov, PW Denton, H Tateno, A Keshavarzi, AL Landay, M Abdel-Mohs
    Mucosal Immunol, 2020-03-09;0(0):.
    Species: Human
    Sample Types: Plasma
  51. African green monkeys avoid SIV disease progression by preventing intestinal dysfunction and maintaining mucosal barrier integrity
    Authors: KD Raehtz, F Barrenäs, C Xu, K Busman-Sah, A Valentine, L Law, D Ma, BB Policicchi, V Wijewardan, E Brocca-Cof, A Trichel, M Gale, BF Keele, JD Estes, C Apetrei, I Pandrea
    PLoS Pathog., 2020-03-02;16(3):e1008333.
    Species: Primate
    Sample Types: Plasma
  52. New signatures of poor CD4 cell recovery after suppressive antiretroviral therapy in HIV-1-infected individuals: involvement of miR-192, IL-6, sCD14 and miR-144
    Authors: F Hernández-, MJ Ruiz-de-Le, I Rosado-Sán, E Vázquez, M Leal, S Moreno, F Vidal, J Blanco, YM Pacheco, A Vallejo
    Sci Rep, 2020-02-19;10(1):2937.
    Species: Human
    Sample Types: Plasma
  53. HIV-1-induced cytokines deplete homeostatic innate lymphoid cells and expand TCF7-dependent memory NK cells
    Authors: Y Wang, L Lifshitz, K Gellatly, CL Vinton, K Busman-Sah, S McCauley, P Vangala, K Kim, A Derr, S Jaiswal, A Kucukural, P McDonel, PW Hunt, T Greenough, J Houghton, M Somsouk, JD Estes, JM Brenchley, M Garber, SG Deeks, J Luban
    Nat. Immunol., 2020-02-17;21(3):274-286.
  54. Plasma FABP4 is associated with liver disease recovery during treatment-induced clearance of chronic HCV infection
    Authors: JB Gorin, DFG Malone, B Strunz, T Carlsson, S Aleman, NK Björkström, K Falconer, JK Sandberg
    Sci Rep, 2020-02-07;10(1):2081.
    Species: Human
    Sample Types: Plasma
  55. Factor Xa Inhibition Reduces Coagulation Activity but Not Inflammation Among People With HIV: A Randomized Clinical Trial
    Authors: JV Baker, J Wolfson, T Peterson, M Mooberry, M Gissel, H Mystakelis, MW Henderson, K Garcia-Mye, FS Rhame, TW Schacker, KE Brummel-Zi, I Sereti, NS Key, RP Tracy
    Open Forum Infect Dis, 2020-02-01;7(2):ofaa026.
    Species: Human
    Sample Types: Serum
  56. Impact of Raltegravir or Efavirenz on Cell-Associated Human Immunodeficiency Virus-1 (HIV-1) Deoxyribonucleic Acid and Systemic Inflammation in HIV-1/Tuberculosis Coinfected Adults Initiating Antiretroviral Therapy
    Authors: HM Delagrever, C Bauduin, N De Castro, B Grinsztejn, M Chevrier, F Jouenne, S Mourah, I Kalidi, JH Pilotto, C Brites, N Tregnago B, A Amara, L Wittkop, JM Molina, C Delaugerre
    Open Forum Infect Dis, 2020-01-11;7(2):ofz549.
    Species: Human
    Sample Types: Whole Blood
  57. Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques
    Authors: JA Manuzak, AS Zevin, R Cheu, B Richardson, J Modesitt, T Hensley-Mc, C Miller, AT Gustin, E Coronado, T Gott, M Fang, M Cartwright, S Wangari, B Agricola, D May, E Smith, HB Hampel, M Gale, CM Cameron, MJ Cameron, J Smedley, NR Klatt
    Mucosal Immunol, 2019-12-04;0(0):.
    Species: Human
    Sample Types: Plasma
  58. Prebiotic UG1601 mitigates constipation-related events in association with gut microbiota: A randomized placebo-controlled intervention study
    Authors: JR Chu, SY Kang, SE Kim, SJ Lee, YC Lee, MK Sung
    World J. Gastroenterol., 2019-10-28;25(40):6129-6144.
    Species: Human
    Sample Types: Serum
  59. Biological variation of immunological blood biomarkers in healthy individuals and quality goals for biomarker tests
    Authors: N Aziz, R Detels, JJ Quint, D Gjertson, T Ryner, AW Butch
    BMC Immunol., 2019-09-14;20(1):33.
    Species: Human
    Sample Types: Serum
  60. Predictors of Obesity among Gut Microbiota Biomarkers in African American Men with and without Diabetes
    Authors: E Barengolts, SJ Green, GE Chlipala, BT Layden, Y Eisenberg, M Priyadarsh, LR Dugas
    Microorganisms, 2019-09-05;7(9):.
    Species: Human
    Sample Types: Serum
  61. Protective HLA alleles are associated with reduced LPS levels in acute HIV infection with implications for immune activation and pathogenesis
    Authors: DT Claiborne, EP Scully, CD Palmer, JL Prince, GN Macharia, J Kopycinski, CM Michelo, HW Wiener, R Parker, K Nganou-Mak, D Douek, M Altfeld, J Gilmour, MA Price, J Tang, W Kilembe, SA Allen, E Hunter
    PLoS Pathog., 2019-08-26;15(8):e1007981.
    Species: Human
    Sample Types: Plasma
  62. Pretransplant Levels of C-Reactive Protein,�Soluble TNF Receptor-1, and�CD38+HLADR+ CD8 T Cells Predict Risk of Allograft Rejection in HIV+ Kidney Transplant Recipients
    Authors: JF Camargo, S Pallikkuth, I Moroz, Y Natori, ML Alcaide, A Rodriguez, G Guerra, GW Burke, S Pahwa
    Kidney Int Rep, 2019-08-19;4(12):1705-1716.
    Species: Human
    Sample Types: Plamsa
  63. Vitamin D and Phenylbutyrate Supplementation Does Not Modulate Gut Derived Immune Activation in HIV-1
    Authors: C Missailidi, N Sørensen, S Ashenafi, W Amogne, E Kassa, A Bekele, M Getachew, N Gebreselas, A Aseffa, G Aderaye, J Andersson, S Brighenti, P Bergman
    Nutrients, 2019-07-21;11(7):.
    Species: Human
    Sample Types: Plasma
  64. Bacterial Translocation and Host Immune Activation in Chronic Hepatitis C Infection
    Authors: MS Moon, G Quinn, EC Townsend, RO Ali, GY Zhang, A Bradshaw, K Hill, H Guan, D Hamilton, DE Kleiner, C Koh, T Heller
    Open Forum Infect Dis, 2019-07-01;6(7):.
    Species: Human
    Sample Types: Serum
  65. Evolving understanding of cardiovascular, cerebrovascular and peripheral arterial disease in people living with HIV and role of novel biomarkers. A study of the Spanish CoRIS cohort, 2004-2015
    Authors: M Masiá, S Padilla, JA García, J García-Abe, M Fernández, I Bernardino, M Montero, J Peraire, B Pernas, F Gutiérrez
    PLoS ONE, 2019-04-26;14(4):e0215507.
    Species: Human
    Sample Types: Plasma
  66. TLR9 polymorphism correlates with immune activation, CD4 decline and plasma IP10 levels in HIV patients
    Authors: A Joshi, EB Punke, T Mehmetoglu, DP Peralta, H Garg
    BMC Infect. Dis., 2019-01-16;19(1):56.
    Species: Human
    Sample Types: Plasma
  67. Enrichment of gut-derived Fusobacterium is associated with suboptimal immune recovery in HIV-infected individuals
    Authors: SC Lee, LL Chua, SH Yap, TF Khang, CY Leng, RI Raja Azwa, SR Lewin, A Kamarulzam, YL Woo, YAL Lim, P Loke, R Rajasuriar
    Sci Rep, 2018-09-24;8(1):14277.
    Species: Human
    Sample Types: Plasma
  68. HIV-1 proviral landscapes distinguish posttreatment controllers from noncontrollers
    Authors: R Sharaf, GQ Lee, X Sun, B Etemad, LM Aboukhater, Z Hu, ZL Brumme, E Aga, RJ Bosch, Y Wen, G Namazi, C Gao, EP Acosta, RT Gandhi, JM Jacobson, D Skiest, DM Margolis, R Mitsuyasu, P Volberding, E Connick, DR Kuritzkes, MM Lederman, XG Yu, M Lichterfel, JZ Li
    J. Clin. Invest., 2018-08-20;0(0):.
    Species: Human
    Sample Types: Plasma
  69. Marital distress, depression, and a leaky gut: Translocation of bacterial endotoxin as a pathway to inflammation
    Authors: JK Kiecolt-Gl, SJ Wilson, ML Bailey, R Andridge, J Peng, LM Jaremka, CP Fagundes, WB Malarkey, B Laskowski, MA Belury
    Psychoneuroendocrinology, 2018-08-04;98(0):52-60.
    Species: Human
    Sample Types: Serum
  70. The CD14 (-159 C/T) SNP is associated with sCD14 levels and allergic asthma, but not with CD14 expression on monocytes
    Authors: JJ Nieto-Font, FJ Salgado, ME San-José, MJ Cruz, A Casas-Fern, MJ Gómez-Cond, L Valdés-Cua, MÁ García-Gon, P Arias, M Nogueira, FJ González-B
    Sci Rep, 2018-03-07;8(1):4147.
    Species: Human
    Sample Types: Serum
  71. The NLRP3 Inflammasome Is Upregulated in HIV-Infected Antiretroviral Therapy-Treated Individuals with Defective Immune Recovery
    Authors: A Bandera, M Masetti, M Fabbiani, M Biasin, A Muscatello, N Squillace, M Clerici, A Gori, D Trabattoni
    Front Immunol, 2018-02-12;9(0):214.
    Species: Human
    Sample Types: Plasma
  72. Aged Chinese-origin rhesus macaques infected with SIV develop marked viremia in absence of clinical disease, inflammation or cognitive impairment
    Authors: SJ Bissel, K Gurnsey, HP Jedema, NF Smith, G Wang, CW Bradberry, CA Wiley
    Retrovirology, 2018-02-01;15(1):17.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Plasma Rich Growth Factors
  73. Prior to extension, Transcriptomes of fibroblast-like Synoviocytes from extended and Polyarticular juvenile idiopathic arthritis are indistinguishable
    Authors: AC Brescia, MM Simonds, SM McCahan, KE Sullivan, CD Rose
    Pediatr Rheumatol Online J, 2018-01-08;16(1):3.
    Species: Human
    Sample Types: Synovial Fluid
  74. Monocyte activation detected prior to a diagnosis of schizophrenia in the US Military New Onset Psychosis Project (MNOPP)
    Authors: NS Weber, KL Gressitt, DN Cowan, DW Niebuhr, RH Yolken, EG Severance
    Schizophr. Res., 2018-01-06;0(0):.
    Species: Human
    Sample Types: Serum
  75. A Pilot Study of Immune Activation and Rifampin Absorption in HIV-Infected Patients without Tuberculosis Infection: A Short Report
    Authors: C Vinnard, I Manley, B Scott, M Bernui, J Adams, S Varghese, I Zentner, MA Kutzler
    Tuberc Res Treat, 2017-12-21;2017(0):2140974.
    Species: Human
    Sample Types: Plasma
  76. Elevated Neopterin Levels Predict Early Death in Older Hip-fracture Patients
    Authors: M Larsen, C Bayard, H Lepetitcor, J Cohen-Bitt, V Appay, J Boddaert, D Sauce
    EBioMedicine, 2017-11-06;0(0):.
    Species: Human
    Sample Types: Plasma
  77. Reevaluation of immune activation in the era of cART and an aging HIV-infected population
    Authors: LR de Armas, S Pallikkuth, V George, S Rinaldi, R Pahwa, KL Arheart, S Pahwa
    JCI Insight, 2017-10-19;2(20):.
    Species: Human
    Sample Types: Plasma
  78. Prospective Analysis of Lipid Composition Changes with Antiretroviral Therapy and Immune Activation in Persons Living with HIV
    Authors: MA Belury, E Bowman, J Gabriel, B Snyder, M Kulkarni, M Palettas, X Mo, JE Lake, D Zidar, SF Sieg, B Rodriguez, MP Playford, A Andrade, DR Kuritzkes, NN Mehta, MM Lederman, NT Funderburg
    Pathog Immun, 2017-10-06;2(3):376-403.
    Species: Human
    Sample Types: Plasma
  79. Impact of monotherapy on HIV-1 reservoir, immune activation, and co-infection with Epstein-Barr virus
    Authors: MR Petrara, AM Cattelan, L Sasset, R Freguja, F Carmona, S Sanavia, M Zanchetta, P Del Bianco, A De Rossi
    PLoS ONE, 2017-09-19;12(9):e0185128.
    Species: Human
    Sample Types: Plasma
  80. Quantity of alcohol drinking positively correlates with serum levels of endotoxin and markers of monocyte activation
    Authors: S Liangpunsa, E Toh, RA Ross, LE Heathers, K Chandler, A Oshodi, B McGee, E Modlik, T Linton, D Mangiacarn, C Jimenez, XC Dong, L Wang, W Tu, DE Nelson
    Sci Rep, 2017-06-30;7(1):4462.
    Species: Human
    Sample Types: Serum
  81. Changes in inflammatory biomarkers in HCV-infected patients undergoing direct acting antiviral-containing regimens with or without interferon
    Authors: C Mascia, S Vita, P Zuccalà, R Marocco, T Tieghi, S Savinelli, R Rossi, M Iannetta, I Pozzetto, C Furlan, F Mengoni, CM Mastroiann, V Vullo, M Lichtner
    PLoS ONE, 2017-06-21;12(6):e0179400.
    Species: Human
    Sample Types: Plasma
  82. Aberrant monocyte responses predict and characterize dengue virus infection in individuals with severe disease
    Authors: YK Yong, HY Tan, SH Jen, EM Shankar, SK Natkunam, J Sathar, R Manikam, SD Sekaran
    J Transl Med, 2017-05-31;15(1):121.
    Species: Human
    Sample Types: Plasma
  83. Association of Anisocytosis with Markers of Immune Activation and Exhaustion in Treated HIV
    Authors: SG Al-Kindi, DA Zidar, GA McComsey, CT Longenecke
    Pathog Immun, 2017-05-02;2(1):138-150.
    Species: Human
    Sample Types: Plasma
  84. Plasma IP-10 Concentrations Correlate Positively with Viraemia and Inversely with CD4 Counts in Untreated HIV Infection
    Authors: K Mhandire, T Mlambo, LS Zijenah, K Duri, K Mateveke, M Tshabalala, DZ Mhandire, C Musarurwa, PT Wekare, LR Mazengera, HT Matarira, B Stray-Pede
    Open AIDS J, 2017-04-26;11(0):24-31.
    Species: Human
    Sample Types: Plasma
  85. Impact of probiotic Saccharomyces boulardii on the gut microbiome composition in HIV-treated patients: A double-blind, randomised, placebo-controlled trial
    Authors: J Villar-Gar, R Güerri-Fer, A Moya, A González, JJ Hernández, E Lerma, A Guelar, L Sorli, JP Horcajada, A Artacho, G D Auria, H Knobel
    PLoS ONE, 2017-04-07;12(4):e0173802.
    Species: Human
    Sample Types: Serum
  86. Lower Baseline Germinal Center Activity and Preserved Th1 Immunity Are Associated With Hepatitis B Vaccine Response in Treated HIV Infection
    Authors: RM Paris, LG Milagres, E Moysi, JF Okulicz, BK Agan, A Ganesan, C Petrovas, RA Koup
    Pathog Immun, 2017-03-14;2(1):66-88.
    Species: Human
    Sample Types: Plasma
  87. Fecal Bacterial Communities in treated HIV infected individuals on two antiretroviral regimens
    Authors: S Pinto-Card, C Lozupone, O Briceño, S Alva-Herná, N Téllez, A Adriana, A Murakami-O, G Reyes-Terá
    Sci Rep, 2017-03-06;7(0):43741.
    Species: Human
    Sample Types: Plasma
  88. Interleukin-1 receptor antagonist, a biomarker of response to anti-TB treatment in HIV/TB co-infected patients
    Authors: J Nouhin, P Pean, Y Madec, MF Chevalier, C Didier, L Borand, FX Blanc, D Scott-Alga, D Laureillar, L Weiss
    J. Infect, 2017-02-09;0(0):.
    Species: Human
    Sample Types: Plasma
  89. Lack of effect of Maraviroc intensification on blood and gut reservoir
    Authors: Juan Tiraboschi
    AIDS Res. Hum. Retroviruses, 2017-02-01;0(0):.
    Species: Human
    Sample Types: Plasma
  90. Cerebrospinal fluid microglia and neurodegenerative markers in twins concordant and discordant for psychotic disorders
    Authors: Viktoria Johansson
    Eur Arch Psychiatry Clin Neurosci, 2016-12-30;0(0):.
    Species: Human
    Sample Types: CSF
  91. Kinetics of Myeloid-Derived Suppressor Cell Frequency and Function during Simian Immunodeficiency Virus Infection, Combination Antiretroviral Therapy, and Treatment Interruption
    Authors: Sandra E Dross
    J. Immunol, 2016-12-14;0(0):.
    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Plasma
  92. Microbial Translocation and Inflammation Occur in Hyperacute Immunodeficiency Virus Infection and Compromise Host Control of Virus Replication
    PLoS Pathog, 2016-12-07;12(12):e1006048.
    Species: Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
    Sample Types: Plasma
  93. Increased cell-free mitochondrial DNA is a marker of ongoing inflammation and better neurocognitive function in virologically suppressed HIV-infected individuals
    Authors: Josué Pérez-Sant
    J. Neurovirol, 2016-12-05;0(0):.
    Species: Human
    Sample Types: Plasma
  94. Immune Activation and Bacterial Translocation: A Link between Impaired Immune Recovery and Frequent Visceral Leishmaniasis Relapses in HIV-Infected Patients
    PLoS ONE, 2016-12-01;11(12):e0167512.
    Species: Human
    Sample Types: Plasma
  95. Impairment of CCR6+ and CXCR3+ Th Cell Migration in HIV-1 Infection Is Rescued by Modulating Actin Polymerization
    Authors: Valentina Cecchinato
    J. Immunol, 2016-11-28;0(0):.
    Species: Human
    Sample Types: Plasma
  96. Immune Activation at Sites of HIV/TB Co-Infection Contributes to the Pathogenesis of HIV-1 Disease
    PLoS ONE, 2016-11-21;11(11):e0166954.
    Species: Human
    Sample Types: Complex Sample Type, Plasma
  97. Soluble CD14 inhibits contractile function and insulin action in primary adult rat cardiomyocytes
    Authors: D Margriet Ouwens
    Biochim. Biophys. Acta, 2016-11-03;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  98. Altered Monocyte and Endothelial Cell Adhesion Molecule Expression Is Linked to Vascular Inflammation in Human Immunodeficiency Virus Infection
    Authors: M Kulkarni, E Bowman, J Gabriel, T Amburgy, E Mayne, DA Zidar, C Maierhofer, AN Turner, JA Bazan, SL Koletar, MM Lederman, SF Sieg, NT Funderburg
    Open Forum Infect Dis, 2016-10-15;3(4):ofw224.
    Species: Human
    Sample Types: Plasma
  99. Immunity in young adult survivors of childhood leukemia is more similar to elderly rather than age-matched controls: Role of cytomegalovirus (CMV)
    Eur J Immunol, 2016-05-19;0(0):.
    Species: Human
    Sample Types: Plasma
  100. HCV Specific IL-21 Producing T Cells but Not IL-17A Producing T Cells Are Associated with HCV Viral Control in HIV/HCV Coinfection
    PLoS ONE, 2016-04-28;11(4):e0154433.
    Species: Human
    Sample Types: Plasma
  101. P2X7 Receptor Inhibition Improves CD34 T-Cell Differentiation in HIV-Infected Immunological Nonresponders on c-ART
    Authors: I Menkova-Ga, H Hocini, E Foucat, P Tisserand, L Bourdery, C Delaugerre, C Benne, Y Lévy, JD Lelièvre
    PLoS Pathog, 2016-04-15;12(4):e1005571.
    Species: Human
    Sample Types: Plasma
  102. Bacteroides are associated with GALT iNKT cell function and reduction of microbial translocation in HIV-1 infection
    Authors: D Paquin-Pro, C Ching, I Vujkovic-C, D Fadrosh, L Loh, Y Huang, M Somsouk, SV Lynch, PW Hunt, DF Nixon, D SenGupta
    Mucosal Immunol, 2016-04-06;0(0):.
    Species: Human
    Sample Types: Plasma
  103. Widespread activation of immunity and pro-inflammatory programs in peripheral blood leukocytes of HIV-infected patients with impaired lung gas exchange
    Authors: K Crothers, I Petrache, C Wongtrakoo, PJ Lee, LM Schnapp, SA Gharib
    Physiol Rep, 2016-04-01;4(8):.
    Species: Human
    Sample Types: Serum
  104. Antibiotic and Antiinflammatory Therapy Transiently Reduces Inflammation and Hypercoagulation in Acutely SIV-Infected Pigtailed Macaques.
    Authors: Pandrea I, Xu C, Stock J, Frank D, Ma D, Policicchio B, He T, Kristoff J, Cornell E, Haret-Richter G, Trichel A, Ribeiro R, Tracy R, Wilson C, Landay A, Apetrei C
    PLoS Pathog, 2016-01-14;12(1):e1005384.
    Species: Human, Primate - Macaca nemestrina (Southern Pig-tailed Macaque)
    Sample Types: Plasma
  105. Loss of intraepidermal nerve fiber density during SIV peripheral neuropathy is mediated by monocyte activation and elevated monocyte chemotactic proteins.
    Authors: Lakritz J, Robinson J, Polydefkis M, Miller A, Burdo T
    J Neuroinflammation, 2015-12-18;12(0):237.
    Species: Primate
    Sample Types: Plasma
  106. Late Antiretroviral Therapy (ART) Initiation Is Associated with Long-Term Persistence of Systemic Inflammation and Metabolic Abnormalities.
    Authors: Ghislain M, Bastard J, Meyer L, Capeau J, Fellahi S, Gerard L, May T, Simon A, Vigouroux C, Goujard C
    PLoS ONE, 2015-12-04;10(12):e0144317.
    Species: Human
    Sample Types: Serum
  107. Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption.
    Authors: Rothenberger, Meghan K, Keele, Brandon, Wietgrefe, Stephen, Fletcher, Courtney, Beilman, Gregory, Chipman, Jeffrey, Khoruts, Alexande, Estes, Jacob D, Anderson, Jodi, Callisto, Samuel P, Schmidt, Thomas E, Thorkelson, Ann, Reilly, Cavan, Perkey, Katherin, Reimann, Thomas G, Utay, Netanya, Nganou Makamdop, Krystell, Stevenson, Mario, Douek, Daniel C, Haase, Ashley T, Schacker, Timothy
    Proc Natl Acad Sci U S A, 2015-02-23;112(10):E1126-34.
    Species: Human
    Sample Types: Plasma
  108. Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4+ T cells, and disease progression.
    Authors: Claiborne, Daniel T, Prince, Jessica, Scully, Eileen, Macharia, Gladys, Micci, Luca, Lawson, Benton, Kopycinski, Jakub, Deymier, Martin J, Vanderford, Thomas H, Nganou-Makamdop, Krystell, Ende, Zachary, Brooks, Kelsie, Tang, Jianming, Yu, Tianwei, Lakhi, Shabir, Kilembe, William, Silvestri, Guido, Douek, Daniel, Goepfert, Paul A, Price, Matthew, Allen, Susan A, Paiardini, Mirko, Altfeld, Marcus, Gilmour, Jill, Hunter, Eric
    Proc Natl Acad Sci U S A, 2015-02-17;112(12):E1480-9.
    Species: Human
    Sample Types: Plasma
  109. Elevated plasma soluble CD14 and skewed CD16+ monocyte distribution persist despite normalisation of soluble CD163 and CXCL10 by effective HIV therapy: a changing paradigm for routine HIV laboratory monitoring?
    Authors: Castley, Alison, Berry, Cassandr, French, Martyn, Fernandez, Sonia, Krueger, Romano, Nolan, David
    PLoS ONE, 2014-12-29;9(12):e115226.
    Species: Human
    Sample Types: Plasma
  110. The immunologic effects of mesalamine in treated HIV-infected individuals with incomplete CD4+ T cell recovery: a randomized crossover trial.
    Authors: Somsouk, Ma, Dunham, Richard, Cohen, Michelle, Albright, Rebecca, Abdel-Mohsen, Mohamed, Liegler, Teri, Lifson, Jeffrey, Piatak, Michael, Gorelick, Robert, Huang, Yong, Wu, Yuaner, Hsue, Priscill, Martin, Jeffrey, Deeks, Steven G, McCune, Joseph M, Hunt, Peter W
    PLoS ONE, 2014-12-29;9(12):e116306.
    Species: Human
    Sample Types: Plasma
  111. Shift in monocyte apoptosis with increasing viral load and change in apoptosis-related ISG/Bcl2 family gene expression in chronically HIV-1-infected subjects.
    Authors: Patro S, Pal S, Bi Y, Lynn K, Mounzer K, Kostman J, Davuluri R, Montaner L
    J Virol, 2014-10-29;89(1):799-810.
    Species: Human
    Sample Types: Plasma
  112. Coinfection with human herpesvirus 8 is associated with persistent inflammation and immune activation in virologically suppressed HIV-infected patients.
    Authors: Masia M, Robledano C, Ortiz de la Tabla V, Antequera P, Lumbreras B, Hernandez I, Gutierrez F
    PLoS ONE, 2014-08-18;9(8):e105442.
    Species: Human
    Sample Types: Plasma
  113. Progressive proximal-to-distal reduction in expression of the tight junction complex in colonic epithelium of virally-suppressed HIV+ individuals.
    Authors: Chung, Charlott, Alden, Stephani, Funderburg, Nicholas, Fu, Pingfu, Levine, Alan D
    PLoS Pathog, 2014-06-26;10(6):e1004198.
    Species: Human
    Sample Types: Plasma
  114. Pathogenic features associated with increased virulence upon Simian immunodeficiency virus cross-species transmission from natural hosts.
    Authors: Mandell D, Kristoff J, Gaufin T, Gautam R, Ma D, Sandler N, Haret-Richter G, Xu C, Aamer H, Dufour J, Trichel A, Douek D, Keele B, Apetrei C, Pandrea I
    J Virol, 2014-04-02;88(12):6778-92.
    Species: Primate - Macaca nemestrina (Southern Pig-tailed Macaque)
    Sample Types: Plasma
  115. Reduced IgM levels and elevated IgG levels against oxidized low-density lipoproteins in HIV-1 infection.
    Authors: Yilmaz A, Jennbacken K, Fogelstrand L
    BMC Infect Dis, 2014-03-17;14(0):143.
    Species: Human
    Sample Types: Plasma
  116. Factors associated with siman immunodeficiency virus transmission in a natural African nonhuman primate host in the wild.
    Authors: Ma, Dongzhu, Jasinska, Anna J, Feyertag, Felix, Wijewardana, Viskam, Kristoff, Jan, He, Tianyu, Raehtz, Kevin, Schmitt, Christop, Jung, Yoon, Cramer, Jennifer, Dione, Michel, Antonio, Martin, Tracy, Russell, Turner, Trudy, Robertson, David L, Pandrea, Ivona, Freimer, Nelson, Apetrei, Cristian
    J Virol, 2014-03-12;88(10):5687-705.
    Species: Human
    Sample Types: Plasma
  117. Plasma sCD14 as a biomarker to predict pulmonary exacerbations in cystic fibrosis.
    Authors: Quon B, Ngan D, Wilcox P, Man S, Sin D
    PLoS ONE, 2014-02-20;9(2):e89341.
    Species: Human
    Sample Types: Plasma
  118. Activation of NK cells is associated with HIV-1 disease progression.
    Authors: Kuri-Cervantes L, de Oca G, Avila-Rios S, Hernandez-Juan R, Reyes-Teran G
    J Leukoc Biol, 2014-01-07;96(1):7-16.
    Species: Human
    Sample Types: Plasma
  119. Dynamics of immune reconstitution and activation markers in HIV+ treatment-naive patients treated with raltegravir, tenofovir disoproxil fumarate and emtricitabine.
    Authors: Funderburg N, Andrade A, Chan E, Rosenkranz S, Lu D, Clagett B, Pilch-Cooper H, Rodriguez B, Feinberg J, Daar E, Mellors J, Kuritzkes D, Jacobson J, Lederman M
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    Species: Human
    Sample Types: Plasma
  120. Prospective antiretroviral treatment of asymptomatic, HIV-1 infected controllers.
    Authors: Hatano, Hiroyu, Yukl, Steven A, Ferre, April L, Graf, Erin H, Somsouk, Ma, Sinclair, Elizabet, Abdel-Mohsen, Mohamed, Liegler, Teri, Harvill, Kara, Hoh, Rebecca, Palmer, Sarah, Bacchetti, Peter, Hunt, Peter W, Martin, Jeffrey, McCune, Joseph M, Tracy, Russell, Busch, Michael, O'Doherty, Una, Shacklett, Barbara, Wong, Joseph K, Deeks, Steven G
    PLoS Pathog, 2013-10-10;9(10):e1003691.
    Species: Human
    Sample Types: Plasma
  121. Predictive value of liver enzymes and inflammatory biomarkers for the severity of liver fibrosis stage in HIV/HCV co-infected patients.
    Authors: Charpentier C, Champenois K, Gervais A, Landman R, Joly V, Le Gac S, Larrouy L, Damond F, Brun-Vezinet F, Descamps D, Yazdanpanah Y
    PLoS ONE, 2013-03-19;8(3):e59205.
    Species: Human
    Sample Types: Plasma
  122. Transcriptional effects of 1,25 dihydroxyvitamin D(3) physiological and supra-physiological concentrations in breast cancer organotypic culture.
    Authors: Milani C, Katayama M, de Lyra E, Welsh J, Campos L, Brentani M, Maciel M, Roela R, del Valle P, Goes J, Nonogaki S, Tamura R, Folgueira M
    BMC Cancer, 2013-03-15;13(0):119.
    Species: Human
    Sample Types: Cell Culture Supernates
  123. Decreased IL-7 responsiveness is related to oxidative stress in HIV disease.
    Authors: Kalinowska M, Bazdar D, Lederman M, Funderburg N, Sieg S
    PLoS ONE, 2013-03-07;8(3):e58764.
    Species: Human
    Sample Types: Serum
  124. SIVagm infection in wild African green monkeys from South Africa: epidemiology, natural history, and evolutionary considerations.
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    PLoS Pathog, 2013-01-17;9(1):e1003011.
    Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
    Sample Types: Plasma
  125. Therapeutic helminth infection of macaques with idiopathic chronic diarrhea alters the inflammatory signature and mucosal microbiota of the colon.
    Authors: Broadhurst, Mara Jan, Ardeshir, Amir, Kanwar, Bittoo, Mirpuri, Julie, Gundra, Uma Mahe, Leung, Jacqueli, Wiens, Kirsten, Vujkovic-Cvijin, Ivan, Kim, Charlie, Yarovinsky, Felix, Lerche, Nicholas, McCune, Joseph M
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    Species: Human
    Sample Types: Plasma
  126. Shared monocyte subset phenotypes in HIV-1 infection and in uninfected subjects with acute coronary syndrome.
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    Species: Human
    Sample Types: Plasma
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    Species: Human
    Sample Types: Plasma
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    Species: Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Plasma
  129. Altered monocyte activation markers in Tourette's syndrome: a case-control study.
    Authors: Matz J, Krause DL, Dehning S, Riedel M, Gruber R, Schwarz MJ, Muller N
    BMC Psychiatry, 2012-05-18;12(0):29.
    Species: Human
    Sample Types: Serum
  130. The relationship of systemic inflammation to prior hospitalization in adult patients with cystic fibrosis.
    Authors: Ngan D, Wilcox P, Aldaabil M, Li Y, Leipsic J, Sin D, Man S
    BMC Pulm Med, 2012-02-14;12(0):3.
    Species: Human
    Sample Types: Plasma
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    Species: Human
    Sample Types: Plasma
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    Species: Human
    Sample Types: Milk
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    AIDS, 2010-06-19;24(10):1509-17.
    Species: Human
    Sample Types: Plasma
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    Blood, 2009-10-14;115(2):161-7.
    Species: Human
    Sample Types: Plasma
  135. Cutting edge: Experimentally induced immune activation in natural hosts of simian immunodeficiency virus induces significant increases in viral replication and CD4+ T cell depletion.
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    Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
    Sample Types: Plasma
  136. Ethnic and sex differences in circulating endotoxin levels: A novel marker of atherosclerotic and cardiovascular risk in a British multi-ethnic population.
    Authors: Miller MA, McTernan PG, Harte AL, Silva NF, Strazzullo P, Alberti KG, Kumar S, Cappuccio FP
    Atherosclerosis, 2008-07-01;203(2):494-502.
    Species: Human
    Sample Types: Plasma
  137. Breast milk fatty acids may link innate and adaptive immune regulation: analysis of soluble CD14, prostaglandin E2, and fatty acids.
    Authors: Laitinen K, Hoppu U, Hamalainen M, Linderborg K, Moilanen E, Isolauri E
    Pediatr. Res., 2006-05-01;59(5):723-7.
    Species: Human
    Sample Types: Serum
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    J. Immunol., 2004-04-01;172(7):4470-9.
    Species: Human
    Sample Types: Serum
  139. Reduced interferon gamma production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of age.
    Authors: Guerra S, Lohman IC, Halonen M, Martinez FD, Wright AL
    Am. J. Respir. Crit. Care Med., 2003-10-02;169(1):70-6.
    Species: Human
    Sample Types: Serum
  140. TGF-beta in human milk is associated with wheeze in infancy.
    Authors: Oddy WH, Halonen M, Martinez FD, Lohman IC, Stern DA, Kurzius-Spencer M, Guerra S, Wright AL
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    Species: Human
    Sample Types: Milk

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Reviews for Human CD14 Quantikine ELISA Kit

Average Rating: 4.6 (Based on 11 Reviews)

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Human CD14 Quantikine ELISA Kit
By Anonymous on 11/21/2022
Sample Tested: Serum

I have used it for serum sample. Background was very low hence the sensitivity of the assay was brilliant. Standard curve was ran in row A and B in the figure. Blank is is A12.

Human CD14 Quantikine ELISA Kit DC140
Human CD14 Quantikine ELISA Kit
By James AHODANTIN on 11/15/2022
Sample Tested: EDTA Plasma
Human CD14 Quantikine ELISA Kit DC140
Human CD14 Quantikine ELISA Kit
By Jonathan Sturgeon on 03/22/2021
Sample Tested: EDTA Plasma

Great kit frequently used. R2 on standard curve >0.999 (attached). Recommended.

Human CD14 Quantikine ELISA Kit DC140
Human CD14 Quantikine ELISA Kit
By Anonymous on 03/17/2021
Sample Tested: Cerebrospinal Fluid,Serum
Human CD14 Quantikine ELISA Kit DC140
Human CD14 Quantikine ELISA Kit
By Anonymous on 11/13/2020
Sample Tested: Human serum

Easy to follow protocol.

Human CD14 Quantikine ELISA Kit DC140
Human CD14 Quantikine ELISA Kit
By APK Inmunometabolismo on 11/06/2020
Sample Tested: Cell culture supernatant
Human CD14 Quantikine ELISA Kit DC140
Human CD14 Quantikine ELISA Kit
By Anonymous on 10/03/2018
Sample Tested: EDTA Plasma
Human CD14 Quantikine ELISA Kit DC140
Human CD14 Quantikine ELISA Kit
By Anonymous on 10/03/2018
Sample Tested: EDTA Plasma
Human CD14 Quantikine ELISA Kit DC140
Human CD14 Quantikine ELISA Kit
By Leslie Priddy on 03/30/2018
Sample Tested: Serum
Human CD14 Quantikine ELISA Kit
By Anonymous on 02/08/2017
Sample Tested: Human EDTA plasma
Human CD14 Quantikine ELISA Kit DC140
Human CD14 Quantikine ELISA Kit
By Anonymous on 12/15/2016
Sample Tested: EDTA Plasma

Plasma was isolated from blood drawn in EDTA tubes from HIV+/ART subjects and from healthy HIV- controls. sCD14 levels were measured in plasma using the Quantikine elisa Human sCD14 kit (cat# DC140). Plasma was diluted 1:200 before use in assay. Assay was carried out according to protocol provided in kit.

Figure legends:
a)Standard curve for sCD14 from which plasma sCD14 values were extrapolated.
b)Quantitated data from HIV+/ART and healthy subjects measured using the kit.

Results are expressed in ng/ml and significance calculated using unpaired Mann Whitney U-test.

Human CD14 Quantikine ELISA Kit DC140