Human CD4 (NP_000607) VersaClone cDNA

Human CD4 (NP_000607) VersaClone cDNA Summary

Specifications

Product Datasheets

Background: CD4

CD4 is a transmembrane glycoprotein that is expressed predominantly on thymocytes and a subset of mature T lymphocytes. It is a standard phenotype marker for the identification of T cell populations. CD4 is expressed along with CD8 on double positive T cells during their development in the thymus. Either CD4 or CD8 expression is then lost, giving rise to single positive (SP) CD4+ or CD8+ mature T cells. CD4+ SP cells, also known as T helper cells, further differentiate into multiple subsets of CD4+ cells including Th1, Th2, Th9, Th17,Th22, Tfh, and Treg cells which regulate humoral and cellular immunity. In human, CD4 is additionally expressed on macrophages, neutrophils, monocytes, NK cells, and neurons and glial cells in the brain. CD4 binds directly to MHC class II molecules on antigen presenting cells. This interaction contributes to the formation of the immunological synapse which is focused around the TCR-MHC class II-antigenic peptide interaction. CD4 also functions as a chemotactic receptor for IL-16 and, in human, as a coreceptor for the gp120 surface glycoprotein of HIV-1.

Related Research Areas

• Conventional/Classical Dendritic Cells
• gamma delta T Cells
• Infectious Diseases
• Leukocyte Receptors/Markers in Allergy and Asthma
• Leukocyte Receptors/Markers in Tfh Cell Differentiation and Function
• LTi Cells
• Lymphoid Lineage Markers
• Natural Killer T (NKT) Cells
• Regulatory T Cells (Tregs)
• Th1 Cells
• Th17 Cells
• Th2 Cells
• Th22 Cells
• Th9 Cells