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Human Complement Factor H-related 2/CFHR2 Antibody

Catalog #: MAB5484
3 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB5484
MAB5484-SP
Product Details
Citations (3)
FAQs
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Complement Factor H-related 2/CFHR2 Antibody Summary

Species Reactivity
Human
Specificity
Detects human Complement Factor H-related 2/CFHR2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross‑reactivity with recombinant human (rh) CFHR1 or rhCFHR5 is observed.
Source
Monoclonal Mouse IgG1 Clone # 510511
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Complement Factor H-related 2/CFHR2
Glu19-Glu268
Accession # P36980
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human Complement Factor H-related 2/CFHR2
Immunoprecipitation
25 µg/mL
Conditioned cell culture medium spiked with Recombinant Human
Complement Factor H‑related 2/CFHR2, see our available Western blot detection antibodies

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Complement Factor H-related 2/CFHR2

Complement Factor H-related 2 (CFHR2) is synthesized in the liver and secreted into plasma. It may be involved in complement regulation. It can also be associated with lipoproteins and may play a role in lipid metabolism. Human CFHR2 shares 48% identity with that of rat.

Entrez Gene IDs
3080 (Human)
Alternate Names
CFHL2; CFHL2FHR-2; CFHR2; Complement Factor Hrelated 2; Complement Factor H-related 2; factor H-related gene 2; FHR2; FHR2DDESK59; H factor (complement)-like 3; H factor-like 3; H factor-like protein 2; HFL3; HFL3complement factor H-related protein 2

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Citations for Human Complement Factor H-related 2/CFHR2 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Low Levels of Factor H Family Proteins During Meningococcal Disease Indicate Systemic Processes Rather Than Specific Depletion by Neisseria meningitidis
    Authors: Anna E. van Beek, Richard B. Pouw, Victoria J. Wright, Neneh Sallah, David Inwald, Clive Hoggart et al.
    Frontiers in Immunology
  2. Common haplotypes at the CFH locus and low-frequency variants in CFHR2 and CFHR5 associate with systemic FHR concentrations and age-related macular degeneration
    Authors: Laura Lorés-Motta, Anna E. van Beek, Esther Willems, Judith Zandstra, Gerard van Mierlo, Alfred Einhaus et al.
    The American Journal of Human Genetics
  3. Factor H-Related (FHR)-1 and FHR-2 Form Homo- and Heterodimers, while FHR-5 Circulates Only As Homodimer in Human Plasma
    Authors: Anna E. van Beek, Richard B. Pouw, Mieke C. Brouwer, Gerard van Mierlo, Judy Geissler, Pleuni Ooijevaar-de Heer et al.
    Frontiers in Immunology

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