Human CREG Antibody

Catalog #: AF2380
1 Citation Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
AF2380
AF2380-SP

All CREG Antibodies

Product Details

Citations (1)

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CREG Antibody Summary

Species Reactivity

Human

Specificity

Detects human CREG in direct ELISAs and Western blots. In Western blots, approximately 50% cross-reactivity with recombinant mouse CREG is observed.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

Mouse myeloma cell line NS0-derived recombinant human CREG
Arg32-Gln220
Accession # O75629

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Human CREG

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CREG

CREG is a secreted glycoprotein that belongs to the CREG protein family. It is induced during differentiation of pluripotent cells and is ubiquitously expressed in adult tissues. Mannose-6 phosphate (M6P) modified CREG binds directly to the M6P/IGF2 receptor to inhibit cell growth (1). Human and mouse CREG share approximately 77% amino acid sequence homology.

References

DiBacco, A. and G. Gill (2003) Oncogene 22:5436.

Long Name

Cellular Repressor of E1A-stimulated Genes

Entrez Gene IDs

8804 (Human); 433375 (Mouse)

Alternate Names

cellular repressor of E1A-stimulated genes 1CREG; cellular repressor of E1A-stimulated genes; CREG; CREG1; protein CREG1

Product Datasheets

Product Datasheet

COA

SDS

Related Research Areas

Citation for Human CREG Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

CREG inhibits migration of human vascular smooth muscle cells by mediating IGF-II endocytosis.
Authors: Han Y, Cui J, Tao J, Guo L, Guo P, Sun M, Kang J, Zhang X, Yan C, Li S
Exp. Cell Res., 2009-09-19;315(19):3301-11.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot