Human CTGF/CCN2 C-Terminus Antibody Summary
Glu247-Ala349
Accession # NP_001892.1
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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CTGF/CCN2 in Human Breast Cancer Tissue. CTGF/CCN2 was detected in immersion fixed paraffin-embedded sections of human breast cancer tissue using 25 µg/mL Human CTGF/CCN2 C-Terminus Monoclonal Antibody (Catalog # MAB660) overnight at 4 °C. Tissue was stained with the Anti-Mouse HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS002) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
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Detection of Human CTGF/CCN2 by Immunohistochemistry Immunostaining of neuroendocrine tumors. Representative photomicrographs demonstrating anti-connective tissue growth factor (CCN2) (panel A) immunostaining of gut carcinoid tumor tissue. CCN2 immunoreactivity was seen in cells corresponding to chromogranin A-positive tumor cells and gut smooth muscle (denoted by arrows in panels B and C, respectively). All sections were counterstained with hematoxylin. Magnification ×50. Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/20053285), licensed under a CC-BY license. Not internally tested by R&D Systems.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CTGF/CCN2
CTGF belongs to the CCN (CYR61/CTGF/NOV) family of secreted proteins that share a common multimodular organization. Each protein contains IGF-binding protein domain, a von Willebrand factor type C domain, a thrombospondin type I domain, and a cysteine knot domain. The multimodular CTGF has the ability to bind multiple ligands and has numerous effects on development, differentation, and disease. The C-terminal cysteine knot motif contains the heparin and low density lipoprotein receptor (LDLR) binding sites that contributes to the adhesive and mitogenic properties of CTGF.
Product Datasheets
Citations for Human CTGF/CCN2 C-Terminus Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Spatiotemporal analysis of putative notochordal cell markers reveals CD24 and keratins 8, 18, and 19 as notochord-specific markers during early human intervertebral disc development.
Authors: Rodrigues-Pinto R, Berry A, Piper-Hanley K et al.
J Orthop Res
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Curcumin inhibits TGF-?1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts
Authors: JT Chen, CY Wang, MH Chen
J. Formos. Med. Assoc., 2018-01-17;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Human gingiva transcriptome during wound healing
Authors: Yun Wang
J. Clin. Periodontol, 2017-02-11;0(0):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Anti-CTGF single-chain variable fragment dimers inhibit human airway smooth muscle (ASM) cell proliferation by down-regulating p-Akt and p-mTOR levels.
Authors: Gao W, Cai L, Xu X, Fan J, Xue X, Yan X, Qu Q, Wang X, Zhang C, Wu G
PLoS ONE, 2014-12-05;9(12):e113980.
Species: Human
Sample Types: Recombinant Protein
Applications: ELISA Development -
Associations Between Cardiac Fibrosis and Permanent Atrial Fibrillation in Advanced Heart Failure
Authors: B. ALDHOON, T. KUČERA, N. SMORODINOVÁ, J. MARTÍNEK, V. MELENOVSKÝ, J. KAUTZNER
Physiological Research
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A physiological role for connective tissue growth factor in early wound healing.
Authors: Alfaro, Maria P, Deskins, Desirae, Wallus, Meredith, DasGupta, Jayasri, Davidson, Jeffrey, Nanney, Lillian, A Guney, Michelle, Gannon, Maureen, Young, Pampee P
Lab Invest, 2012-11-19;93(1):81-95.
Species: Mouse
Sample Types: Whole Cells
Applications: Bioassay -
Plasma CCN2/connective tissue growth factor is associated with right ventricular dysfunction in patients with neuroendocrine tumors
Authors: Deidi Strickland Bergestuen, Jørgen Gravning, Kristina Hermann Haugaa, Laura G Sahakyan, Svend Aakhus, Espen Thiis-Evensen et al.
BMC Cancer
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TGF-beta –Stimulated CTGF Production Enhanced by Collagen and Associated with Biogenesis of a Novel 31-kDa CTGF Form in Human Corneal Fibroblasts
Authors: Edward G. Tall, Audrey M. Bernstein, Noelynn Oliver, Julia L. Gray, Sandra K. Masur
Investigative Opthalmology & Visual Science
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CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2-dependent S100A4-upregulated pathway.
Authors: Chen, Pai-Shen, Wang, Ming-Yan, Wu, Shin-Ni, Su, Jen-Lian, Hong, Chih-Che, Chuang, Shuang-E, Chen, Min-Wei, Hua, Kuo-Tai, Wu, Yu-Ling, Cha, Shih-Tin, Babu, Munisamy, Chen, Chiung-N, Lee, Po-Huang, Chang, King-Jen, Kuo, Min-Lian
J Cell Sci, 2007-06-15;120(0):2053-65.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Biomarker discovery from pancreatic cancer secretome using a differential proteomic approach.
Authors: Gronborg M, Kristiansen TZ, Iwahori A, Chang R, Reddy R, Sato N, Molina H, Jensen ON, Hruban RH, Goggins MG, Maitra A, Pandey A
Mol. Cell Proteomics, 2005-10-08;5(1):157-71.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot
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