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Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit

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Human CXCL13/BLC/BCA-1 ELISA Standard Curve
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Summary Sample Values Precision Recovery Linearity Data Examples Product Datasheets Preparation and Storage Background Related Research Areas

Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit Summary

Assay Type
Solid Phase Sandwich ELISA
Format
96-well strip plate
Assay Length
4.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (50 uL), Serum (50 uL), EDTA Plasma (50 uL), Heparin Plasma (50 uL), Saliva (25 uL)
Sensitivity
3.97 pg/mL
Assay Range
7.8 - 500 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Saliva)
Specificity
Natural and recombinant human BLC/BCA-1
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Sample Values

Serum/Plasma/Saliva - Samples from apparently healthy volunteers were evaluated for the presence of human BLC/BCA-1 in this assay. No medical histories were available for the donors used in this study.

Sample TypeMean (pg/mL)Range (pg/mL)Standard Deviation (pg/mL)
Serum* (n=35)81.939.4-25243.5
EDTA plasma (n=35)62.529.4-24642.7
Heparin plasma (n=35)63.521.7-24044.1
*Twenty-five additional serum samples were tested and values of 10.6 pg/mL, 379 pg/mL, and 638 pg/mL were observed in three samples. The remaining samples were consistent with the range listed above.

Sample TypeMean of Detectable (pg/mL)% DetectableRange (pg/mL)
Saliva (n=10)67.470ND-284
ND=Non-Detectable

Cell Culture Supernates:
Human peripheral blood cells (1 x 106 cells/mL) were cultured in RPMI supplemented with 10% fetal bovine serum, 50 μM beta -mercaptoethanol, 2 mM L-glutamine, 100 U/mL penicillin, and 100 μg/mL streptomycin sulfate. Cells were cultured unstimulated or stimulated with 10 μg/mL PHA. Aliquots of the cell culture supernate were removed and assayed for levels of human BLC/BCA-1.

ConditionDay 1 (pg/mL)Day 5 (pg/mL)
UnstimulatedNDND
Stimulated11640
ND=Non-detectable

THP-1 human acute monocytic leukemia cells were cultured in RPMI supplemented with 10% fetal bovine serum, stimulated with 1.0 μg/mL of recombinant human IFN-gamma for eight hours, and then stimulated with 1.0 μg/mL of LPS overnight. An aliquot was removed, assayed for detectable human BLC/BCA-1, and measured 15,922 pg/mL.





Product Summary

The Quantikine Human BLC/BCA-1 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human BLC/BCA-1 in cell culture supernates, serum, plasma, and saliva. It contains E. coli-expressed recombinant human BLC/BCA-1 and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human BLC/BCA-1 showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring BLC/BCA-1.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Saliva

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 40 40 40
Mean (pg/mL) 50.2 136 294 54 138 285
Standard Deviation 2.2 4.5 8 5.1 13.2 24.8
CV% 4.3 3.3 2.7 9.4 9.6 8.7

Recovery

The recovery of natural BLC/BCA-1 spiked to levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Media (n=4) 98 87-110
EDTA Plasma (n=4) 99 92-107
Heparin Plasma (n=4) 101 92-115
Serum (n=4) 99 86-108

Linearity

To assess the linearity of the assay, samples containing and/or spiked with high concentrations of natural BLC/BCA-1 were serially diluted with the Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Human CXCL13/BLC/BCA-1 ELISA Linearity

Scientific Data

N/A Human CXCL13/BLC/BCA-1 ELISA Standard Curve View Larger

Human CXCL13/BLC/BCA-1 ELISA Standard Curve

N/A Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit View Larger

Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit Correlation between European League Against Rheumatism Sjögren’s Syndrome Disease Activity Index (ESSDAI) scores and concentrations of nine screened serum proteins analyzed by ELISA in the validation cohort of patients with primary Sjögren’s syndrome (n = 58). The nine proteins were CXCL13, TNF receptor 2 (TNF-R2), CD48, B-cell activating factor (BAFF), programmed cell death protein 1 ligand 2 (PD-L2), lymphocyte activation gene-3 (LAG-3), beta 2-microglobulin ( beta 2MG), ephrin type-B receptor 2 (EPHB2), and CD163. Pearson’s correlation test was used. The correlation coefficients (r) and P values are shown in the table. P <0.05 was considered significant Image collected and cropped by CiteAb from the following open publication (https://arthritis-research.biomedcentral.com/articles/10.1186/s13075-016-1006-1), licensed under a CC-BY license. Not internally tested by R&D Systems.

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: CXCL13/BLC/BCA-1

CXCL13/BLC/BCA-1 is a constitutively expressed chemokine that plays an important role in B and T cell homing. It is expressed by salivary gland epithelium, dendritic cells, osteoclasts, and peritoneal macrophages. It can form homodimers or heterodimers with FGF basic, and it signals through CXCR3 or CXCR5. CXCL13 induces the migration of naïve B cells and a subset of memory T cells to lymphoid tissue. It also promotes B1 cell migration into the omentum and peritoneum. In the fetus, CXCL13 attracts CD4+ CD3- IL-7 R alpha+ hematopoietic cells to sites of future Peyer’s patch development.

Entrez Gene IDs:
10563 (Human); 55985 (Mouse)
Alternate Names:
ANGIE; ANGIE2; B cell-attracting chemokine 1; B lymphocyte chemoattractant; BCA1; BCA-1; BCA1B-cell chemoattractant; BCA-1CXC chemokine BLC; B-cell-homing chemokine (ligand for Burkitt's lymphoma receptor-1); BLC; BLCSmall-inducible cytokine B13; BLR1L; B-lymphocyte chemoattractant; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); chemokine (C-X-C motif) ligand 13; C-X-C motif chemokine 13; CXCL13; SCYB13; SCYB13B-cell-attracting chemokine 1; small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cellchemoattractant)
&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Assay Procedure

Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.
    3. 100 µL Assay Diluent
  3.   Add 100 µL of Assay Diluent to each well.
    4. 50 µL Standard, Control, or Sample
  4.   Add 50 µL of Standard, control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
  5.   Aspirate each well and wash, repeating the process 3 times for a total of 4 washes.
    6. 200 µL Conjugate
  6.   Add 200 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours.
  7.   Aspirate and wash 4 times.
    8. 200 µL Substrate Solution
  8.   Add 200 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.
    9. 50 µL Stop Solution
  9.   Add 50 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.

Citations for Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

49 Citations: Showing 1 - 10
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  1. Follicular helper- and peripheral helper-like T cells drive autoimmune disease in human immune system mice
    Authors: Vecchione, A;Khosravi-Maharlooei, M;Danzl, N;Li, HW;Nauman, G;Madley, R;Waffarn, E;Winchester, R;Ruiz, A;Ding, X;Fousteri, G;Sykes, M;
    bioRxiv : the preprint server for biology
    Species: Human
    Sample Types: Plasma
  2. CXCL13 in Cerebrospinal Fluid: Clinical Value in a Large Cross-Sectional Study
    Authors: Erhart, DK;Klose, V;Schäper, T;Tumani, H;Senel, M;
    International journal of molecular sciences
    Species: Human
    Sample Types: CSF, Serum
  3. Intrathecal Th17-driven inflammation is associated with prolonged post-treatment convalescence for patients with Lyme neuroborreliosis
    Authors: Gyllemark, P;Sjöwall, J;Forsberg, P;Ernerudh, J;Henningsson, AJ;
    Scientific reports
    Species: Human
    Sample Types: CSF
  4. Safety and immunogenicity following co-administration of Yellow fever vaccine with Tick-borne encephalitis or Japanese encephalitis vaccines: Results from an open label, non-randomized clinical trial
    Authors: JT Sandberg, M Löfling, R Varnait?, J Emgård, N Al-Tawil, L Lindquist, S Gredmark-R, J Klingström, K Loré, K Blom, HG Ljunggren
    PloS Neglected Tropical Diseases, 2023-02-09;17(2):e0010616.
    Species: Human
    Sample Types: Serum
  5. CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease
    Authors: SK Pierson, L Katz, R Williams, M Mumau, M Gonzalez, S Guzman, A Rubenstein, AB Oromendia, P Beineke, A Fosså, F van Rhee, DC Fajgenbaum
    Nature Communications, 2022-11-24;13(1):7236.
    Species: Human
    Sample Types: Serum
  6. Escherichia coli-specific CXCL13-producing TFH are associated with clinical efficacy of neoadjuvant PD-1 blockade against muscle-invasive bladder cancer
    Authors: AG Goubet, L Lordello, C Alves Cost, I Peguillet, M Gazzano, MD Mbogning-F, C Thelemaque, C Lebacle, C Thibault, F Audenet, G Pignot, G Gravis, C Helissey, L Campedel, M Roupret, E Xylinas, I Ouzaid, A Dubuisson, M Mazzenga, C Flament, P Ly, V Marty, N Signolle, A Sauvat, T Sbarrato, M Filahi, C Davin, G Haddad, J Bou Khalil, C Bleriot, FX Danlos, G Dunsmore, K Mulder, A Silvin, T Raoult, B Archambaud, S Belhechmi, I Gomperts B, N Cayet, M Moya-Nilge, A Mallet, R Daillere, E Rouleau, C Radulescu, Y Allory, J Fieschi, M Rouanne, F Ginhoux, G Le Teuff, L Derosa, A Marabelle, J VAN Dorp, N VAN Dijk, MS van der He, B Besse, F Andre, M Merad, G Kroemer, JY Scoazec, L Zitvogel, Y Loriot
    Cancer Discovery, 2022-10-05;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  7. Dynamics of Inflammatory and Neurodegenerative Biomarkers after Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis
    Authors: J Ruder, G Dinner, A Maceski, E Berenjeno-, AM Müller, I Jelcic, J Kuhle, R Martin
    International Journal of Molecular Sciences, 2022-09-19;23(18):.
    Species: Human
    Sample Types: Serum
  8. CXCL13-producing CD4+ T cells accumulate in early phase of tertiary lymphoid structures in ovarian cancer
    Authors: M Ukita, J Hamanishi, H Yoshitomi, K Yamanoi, S Takamatsu, A Ueda, H Suzuki, Y Hosoe, Y Furutake, M Taki, K Abiko, K Yamaguchi, H Nakai, T Baba, N Matsumura, A Yoshizawa, H Ueno, M Mandai
    JCI Insight, 2022-06-22;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  9. Clinical value of urinary cytokines/chemokines as prognostic markers in patients with crescentic glomerulonephritis
    Authors: J Jeon, J Park, HJ Boo, KE Yang, CJ Lee, JE Lee, K Kim, GY Kwon, W Huh, DJ Kim, YG Kim, HR Jang
    Oncogene, 2022-06-17;12(1):10221.
    Species: Human
    Sample Types: Serum
  10. EBV/HHV-6A dUTPases contribute to myalgic encephalomyelitis/chronic fatigue syndrome pathophysiology by enhancing TFH cell differentiation and extrafollicular activities
    Authors: BS Cox, K Alharshawi, I Mena-Palom, WP Lafuse, ME Ariza
    JCI Insight, 2022-06-08;7(11):.
    Species: Human
    Sample Types: Serum
  11. Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis
    Authors: T Robinson, A Abdelhak, T Bose, E Meinl, M Otto, UK Zettl, R Dersch, H Tumani, S Rauer, A Huss
    Cells, 2020-11-25;9(12):.
    Species: Human
    Sample Types: CSF
  12. CXCL13 plasma levels function as a biomarker for disease activity in patients with chronic lymphocytic leukemia
    Authors: M Sivina, L Xiao, E Kim, A Vaca, SS Chen, MJ Keating, A Ferrajoli, Z Estrov, N Jain, WG Wierda, X Huang, N Chiorazzi, JA Burger
    Leukemia, 2020-10-21;0(0):.
    Species: Human
    Sample Types: Plasma
  13. Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle factors and lymphoma development
    Authors: F Saberi Hos, PM Kolijn, D Casabonne, A Nieters, M Solans, S Naudin, P Ferrari, JD Mckay, E Weiderpass, V Perduca, C Besson, FR Mancini, G Masala, V Krogh, F Ricceri, JM Huerta, D Petrova, N Sala, A Trichopoul, A Karakatsan, C La Vecchia, R Kaaks, F Canzian, D Aune, H Boeing, MB Schulze, A Perez-Corn, AW Langerak, VHJ van der Ve, R Vermeulen
    Sci Rep, 2020-08-14;10(1):13814.
    Species: Human
    Sample Types: Serum
  14. Serum and CSF cytokine levels mirror different neuroimmunological mechanisms in patients with LGI1 and Caspr2 encephalitis
    Authors: P Körtvelyes, A Goihl, K Guttek, B Schraven, H Prüss, D Reinhold
    Cytokine, 2020-08-12;135(0):155226.
    Species: Human
    Sample Types: Serum
  15. Ustekinumab inhibits T follicular helper cell differentiation in patients with Crohn's disease
    Authors: AM Globig, NP Sommer, K Wild, J Schardey, K Zoldan, AK Thomann, LA Schulte, R Schreiner, W Reindl, J Klaus, CM Schempp, M Hofmann, R Thimme, T Boettler, P Hasselblat
    Cell Mol Gastroenterol Hepatol, 2020-07-15;0(0):.
    Species: Human
    Sample Types: Plasma
  16. Association between the cytokine storm, immune cell dynamics, and viral replicative capacity in hyperacute HIV infection
    Authors: DM Muema, NA Akilimali, OC Ndumnego, SS Rasehlo, R Durgiah, DBA Ojwach, N Ismail, M Dong, A Moodley, KL Dong, ZM Ndhlovu, JM Mabuka, BD Walker, JK Mann, T Ndung'u
    BMC Med, 2020-03-25;18(1):81.
    Species: Human
    Sample Types: Plasma
  17. Activated circulating T follicular helper cells and skewing of T follicular helper 2�cells are down-regulated by treatment including an inhaled corticosteroid in patients with allergic asthma
    Authors: S Miyajima, K Shigehara, R Kamekura, H Takaki, H Yabe, I Ikegami, Y Asai, H Nishikiori, H Chiba, E Uno, H Takahashi, S Ichimiya
    Allergol Int, 2019-10-22;0(0):.
    Species: Human
    Sample Types: Plasma
  18. Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease
    Authors: A Morou, E Brunet-Rat, M Dubé, R Charlebois, E Mercier, S Darko, N Brassard, K Nganou-Mak, S Arumugam, G Gendron-Le, L Yang, J Niessl, AE Baxter, JM Billingsle, PA Rajakumar, F Lefebvre, RP Johnson, C Tremblay, JP Routy, RT Wyatt, A Finzi, DC Douek, DE Kaufmann
    Nat. Immunol., 2019-07-15;20(8):1059-1070.
    Species: Human
    Sample Types: Cell Culture Supernates
  19. Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis
    Authors: A Ardain, R Domingo-Go, S Das, SW Kazer, NC Howard, A Singh, M Ahmed, S Nhamoyebon, J Rangel-Mor, P Ogongo, L Lu, D Ramsuran, M de la Luz, T K Ulland, M Darby, E Park, F Karim, L Melocchi, R Madansein, KJ Dullabh, M Dunlap, N Marin-Agud, T Ebihara, T Ndung'u, D Kaushal, AS Pym, JK Kolls, A Steyn, J Zúñiga, W Horsnell, WM Yokoyama, AK Shalek, HN Kløverpris, M Colonna, A Leslie, SA Khader
    Nature, 2019-06-05;570(7762):528-532.
    Species: Human
    Sample Types: Plasma
  20. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A
    Authors: EJ Im, CH Lee, PG Moon, GG Rangaswamy, B Lee, JM Lee, JC Lee, JG Jee, JS Bae, TK Kwon, KW Kang, MS Jeong, JE Lee, HS Jung, HJ Ro, S Jun, W Kang, SY Seo, YE Cho, BJ Song, MC Baek
    Nat Commun, 2019-03-27;10(1):1387.
    Species: Human
    Sample Types: Cell Culture Supernates
  21. HIV-specific Fc effector function early in infection predicts the development of broadly neutralizing antibodies
    Authors: SI Richardson, AW Chung, H Natarajan, B Mabvakure, NN Mkhize, N Garrett, S Abdool Kar, PL Moore, ME Ackerman, G Alter, L Morris
    PLoS Pathog., 2018-04-09;14(4):e1006987.
    Species: Human
    Sample Types: Plasma
  22. Point-of-care testing for CXCL13 in Lyme neuroborreliosis
    Authors: A Pietikäine, J Oksi, J Hytönen
    Diagn. Microbiol. Infect. Dis., 2018-02-23;0(0):.
    Species: Human
    Sample Types: CSF
  23. Lower Baseline Germinal Center Activity and Preserved Th1 Immunity Are Associated With Hepatitis B Vaccine Response in Treated HIV Infection
    Authors: RM Paris, LG Milagres, E Moysi, JF Okulicz, BK Agan, A Ganesan, C Petrovas, RA Koup
    Pathog Immun, 2017-03-14;2(1):66-88.
    Species: Human
    Sample Types: Plasma
  24. Elevated C-X-C motif ligand 13 and B-cell-activating factor levels in neuromyelitis optica during remission
    Authors: S Wang, T Yang, J Wan, Y Zhang, Y Fan
    Brain Behav, 2017-03-10;7(4):e00648.
    Species: Human
    Sample Types: Serum
  25. Intrathecal Th17- and B cell-associated cytokine and chemokine responses in relation to clinical outcome in Lyme neuroborreliosis: a large retrospective study
    Authors: P Gyllemark, P Forsberg, J Ernerudh, AJ Henningsso
    J Neuroinflammation, 2017-02-01;14(1):27.
    Species: Human
    Sample Types: Serum
  26. BAFF Index and CXCL13 levels in the cerebrospinal fluid associate respectively with intrathecal IgG synthesis and cortical atrophy in multiple sclerosis at clinical onset
    Authors: M Puthenpara, L Federle, S Miante, A Zito, E Toffanin, S Ruggero, M Ermani, S Pravato, D Poggiali, P Perini, F Rinaldi, P Gallo
    J Neuroinflammation, 2017-01-17;14(1):11.
    Species: Human
    Sample Types: Serum
  27. CXCL13 is a plasma biomarker of germinal center activity
    Proc. Natl. Acad. Sci. U.S.A., 2016-02-23;113(10):2702-7.
    Species: Human, Primate - Macaca mulatta (Rhesus Macaque)
    Sample Types: Plasma
  28. Predictive Value of Cytokines and Immune Activation Biomarkers in AIDS-Related Non-Hodgkin Lymphoma Treated with Rituximab plus Infusional EPOCH (AMC-034 trial).
    Authors: Epeldegui M, Lee J, Martinez A, Widney D, Magpantay L, Regidor D, Mitsuyasu R, Sparano J, Ambinder R, Martinez-Maza O
    Clin Cancer Res, 2015-09-17;22(2):328-36.
    Species: Human
    Sample Types: Plasma
  29. Biomarkers of inflammation and axonal degeneration/damage in patients with newly diagnosed multiple sclerosis: contributions of the soluble CD163 CSF/serum ratio to a biomarker panel.
    Authors: Stilund M, Gjelstrup M, Petersen T, Moller H, Rasmussen P, Christensen T
    PLoS ONE, 2015-04-10;10(4):e0119681.
    Species: Human
    Sample Types: Serum
  30. HIV-1 single-stranded RNA induces CXCL13 secretion in human monocytes via TLR7 activation and plasmacytoid dendritic cell-derived type I IFN.
    Authors: Cohen K, Dugast A, Alter G, McElrath M, Stamatatos L
    J Immunol, 2015-02-09;194(6):2769-75.
    Species: Human
    Sample Types: Plasma
  31. CXCL13 and neopterin concentrations in cerebrospinal fluid of patients with Lyme neuroborreliosis and other diseases that cause neuroinflammation.
    Authors: Hytonen J, Kortela E, Waris M, Puustinen J, Salo J, Oksi J
    J Neuroinflammation, 2014-06-11;11(0):103.
    Species: Human
    Sample Types: CSF
  32. Cerebrospinal fluid immunoglobulin kappa light chain in clinically isolated syndrome and multiple sclerosis.
    Authors: Senel M, Tumani H, Lauda F, Presslauer S, Mojib-Yezdani R, Otto M, Brettschneider J
    PLoS ONE, 2014-04-02;9(4):e88680.
    Species: Human
    Sample Types: CSF
  33. BAFF/APRIL system in pediatric OMS: relation to severity, neuroinflammation, and immunotherapy.
    Authors: Pranzatelli, Michael, Tate, Elizabet, McGee, Nathan R, Travelstead, Anna L, Colliver, Jerry A, Ness, Jayne M, Ransohoff, Richard
    J Neuroinflammation, 2013-01-16;10(0):10.
    Species: Human
    Sample Types: Serum
  34. Cerebrospinal Fluid Neopterin as Marker of the Meningo-Encephalitic Stage of Trypanosoma brucei gambiense Sleeping Sickness.
    Authors: Tiberti N, Hainard A, Lejon V, Courtioux B, Matovu E, Enyaru JC, Robin X, Turck N, Kristensson K, Ngoyi DM, Vatunga GM, Krishna S, Buscher P, Bisser S, Ndung'u JM, Sanchez JC
    PLoS ONE, 2012-07-18;7(7):e40909.
    Species: Human
    Sample Types: CSF
  35. The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS).
    Authors: Brettschneider J, Czerwoniak A, Senel M
    PLoS ONE, 2010-08-05;5(8):e11986.
    Species: Human
    Sample Types: Serum
  36. Serum CXCL13 positively correlates with prostatic disease, prostate-specific antigen and mediates prostate cancer cell invasion, integrin clustering and cell adhesion.
    Authors: Singh S, Singh R, Sharma PK, Singh UP, Rai SN, Chung LW, Cooper CR, Novakovic KR, Grizzle WE, Lillard JW
    Cancer Lett., 2009-04-17;283(1):29-35.
    Species: Human
    Sample Types: Serum
  37. Villitis of unknown etiology is associated with a distinct pattern of chemokine up-regulation in the feto-maternal and placental compartments: implications for conjoint maternal allograft rejection and maternal anti-fetal graft-versus-host disease.
    Authors: Kim MJ, Romero R, Kim CJ, Tarca AL, Chhauy S, LaJeunesse C, Lee DC, Draghici S, Gotsch F, Kusanovic JP, Hassan SS, Kim JS
    J. Immunol., 2009-03-15;182(6):3919-27.
    Species: Human
    Sample Types: Plasma
  38. Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients.
    Authors: Panse J, Friedrichs K, Marx A, Hildebrandt Y, Luetkens T, Bartels K, Horn C, Stahl T, Cao Y, Milde-Langosch K, Niendorf A, Kroger N, Wenzel S, Leuwer R, Bokemeyer C, Hegewisch-Becker S, Atanackovic D
    Br. J. Cancer, 2008-09-16;99(6):930-8.
    Species: Human
    Sample Types: Serum
  39. Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection.
    Authors: Cagigi A, Mowafi F, Phuong Dang LV, Tenner-Racz K, Atlas A, Grutzmeier S, Racz P, Chiodi F, Nilsson A
    Blood, 2008-09-09;112(12):4401-10.
    Species: Human
    Sample Types: Cell Culture Supernates
  40. Potential novel biomarkers of disease activity in rheumatoid arthritis patients: CXCL13, CCL23, transforming growth factor alpha, tumor necrosis factor receptor superfamily member 9, and macrophage colony-stimulating factor.
    Authors: Rioja I, Hughes FJ, Sharp CH, Warnock LC, Montgomery DS, Akil M, Wilson AG, Binks MH, Dickson MC
    Arthritis Rheum., 2008-08-01;58(8):2257-67.
    Species: Human
    Sample Types: Plasma
  41. Increased serum levels of the chemokine CXCL13 and up-regulation of its gene expression are distinctive features of HCV-related cryoglobulinemia and correlate with active cutaneous vasculitis.
    Authors: Sansonno D, Tucci FA, Troiani L, Lauletta G, Montrone M, Conteduca V, Sansonno L, Dammacco F
    Blood, 2008-06-12;112(5):1620-7.
    Species: Human
    Sample Types: Serum
  42. Lymphoid chemokines in chronic neuroinflammation.
    Authors: Aloisi F, Columba-Cabezas S, Franciotta D, Rosicarelli B, Magliozzi R, Reynolds R, Ambrosini E, Coccia E, Salvetti M, Serafini B
    J. Neuroimmunol., 2008-06-09;198(1):106-12.
    Species: Human
    Sample Types: CSF
  43. Loss of IL-7 receptor alpha on CD4+ T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue.
    Authors: Lim HW, Kim CH
    J. Immunol., 2007-12-01;179(11):7448-56.
    Species: Human
    Sample Types: Cell Culture Supernates
  44. Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia.
    Authors: Burkle A, Niedermeier M, Schmitt-Graff A, Wierda WG, Keating MJ, Burger JA
    Blood, 2007-07-25;110(9):3316-25.
    Species: Human
    Sample Types: Serum
  45. High levels of inflammatory chemokines and cytokines in joint fluid and synovial tissue throughout the course of antibiotic-refractory lyme arthritis.
    Authors: Shin JJ, Glickstein LJ, Steere AC
    Arthritis Rheum., 2007-04-01;56(4):1325-35.
    Species: Human
    Sample Types: Synovial Fluid
  46. Follicular dendritic cells are related to bone marrow stromal cell progenitors and to myofibroblasts.
    Authors: Munoz-Fernandez R, Blanco FJ, Frecha C, Martin F, Kimatrai M, Abadia-Molina AC, Garcia-Pacheco JM, Olivares EG
    J. Immunol., 2006-07-01;177(1):280-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  47. Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responses.
    Authors: Lim HW, Hillsamer P, Kim CH
    J. Clin. Invest., 2004-12-01;114(11):1640-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  48. Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis.
    Authors: Casazza S, Zappia E, Pistorio A, Gambini C
    Proc. Natl. Acad. Sci. U.S.A., 2004-07-19;101(30):11064-9.
    Species: Human
    Sample Types: CSF
  49. IL1beta and TNFalpha differently modulate CXCL13 chemokine in stromal cells and osteoblasts isolated from osteoarthritis patients: evidence of changes associated to cell maturation.
    Authors: Lisignoli G, Cristino S, Toneguzzi S, Grassi F, Piacentini A, Cavallo C, Facchini A, Mariani E
    Exp. Gerontol., 2004-04-01;39(4):659-65.
    Species: Human
    Sample Types: Cell Culture Supernates

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Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit
By Anonymous on 06/07/2022
Sample Tested: LNCaP human prostate cancer cell line

The standard curve shows a good fit.
Easy to use, and take ~5hours from start to get a result.

Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit DCX130
Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit
By Anonymous on 10/04/2020
Sample Tested: Serum
Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit
By Chi P on 04/23/2018
Sample Tested: Peripheral blood mononuclear cells (PBMCs)
Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit
By Jessica Fernando on 12/04/2017
Sample Tested: Serum
Human CXCL13/BLC/BCA-1 Quantikine ELISA Kit
By Jessica Fernando on 10/23/2017
Sample Tested: Serum