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Human ERR gamma/NR3B3 Antibody

Catalog #: PP-H6812-00
15 Citations Datasheet / COA / SDS
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PP-H6812-00
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Citations (15)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human ERR gamma/NR3B3 Antibody Summary

Species Reactivity
Human
Source
Monoclonal Mouse IgG2a Clone # H6812
Formulation
A liquid formulation in physiologic saline with 0.1% NaN3.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
Please refer to the PDF datasheet for specifications.
Immunohistochemistry
5-15 µg/mL
Perfusion fixed paraffin-embedded sections of rat retina (inner nuclear layer)
Immunoprecipitation
Please refer to the PDF datasheet for specifications.
Direct ELISA
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: ERR gamma/NR3B3

Estrogen-related receptor alpha (ERR-alpha, ERR1, ESRL1; NR3B1) is a member of the orphan nuclear receptor family. ERR-alpha is expressed in the liver, kidney, brain, heart, uterus, vagina and cervix. ERR-alpha takes part in the cell cycle and the fatty acid metabolizing of the musculus skeleti. ERR-alpha was shown to interact with ER-alpha. ERR-beta (ERR2; NR3B2) is also expressed in the liver, brain, uterus, vagina, and cervix. ERR-beta has a role in early placental development. ERR-gamma (ESRRG; NR3B3) is expressed in the brain, kidney, testis, lung, adrenal gland, pancreas, placenta and bone marrow. ERR-gamma was shown to be located in the critical region for Usher's syndrome.

Long Name
Estrogen-related Receptor gamma
Entrez Gene IDs
2104 (Human)
Alternate Names
DKFZp781L1617; ERR gamma; ERR gamma-2; ERR3; ERRG2; ERRgamma; ESRRG; Estrogen receptor-related protein 3; estrogen-related receptor gamma; FLJ16023; KIAA0832; NR3B3; Nuclear receptor subfamily 3 group B member 3

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Citations for Human ERR gamma/NR3B3 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

15 Citations: Showing 1 - 10
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  1. The transcriptomic landscape of spinal V1 interneurons reveals a role for En1 in specific elements of motor output
    Authors: Trevisan, AJ;Han, K;Chapman, P;Kulkarni, AS;Hinton, JM;Ramirez, C;Klein, I;Gatto, G;Gabitto, MI;Menon, V;Bikoff, JB;
    bioRxiv : the preprint server for biology
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  2. ERR?-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress
    Authors: Jung, YS;Radhakrishnan, K;Hammad, S;Müller, S;Müller, J;Noh, JR;Kim, J;Lee, IK;Cho, SJ;Kim, DK;Kim, YH;Lee, CH;Dooley, S;Choi, HS;
    Redox biology
    Species: Mouse, Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: Immunohistochemistry
  3. Macrophage stimulating protein is a novel transcriptional target of estrogen related receptor gamma in alcohol-intoxicated mice
    Authors: Jung, YS;Radhakrishnan, K;Kim, HJ;Kim, YH;Lee, CH;Choi, HS;
    Cellular signalling
    Species: Mouse
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. An Inverse Agonist of Estrogen-Related Receptor Gamma, GSK5182, Enhances Na+/I− Symporter Function in Radioiodine-Refractory Papillary Thyroid Cancer Cells
    Authors: Thoudam Debraj Singh, Jae Eon Lee, Kwang Hee Son, Bo Ra Lee, Sang Kyoon Kim, Deepak Gulwani et al.
    Cells
  5. ERR2 and ERR3 promote the development of gamma motor neuron functional properties required for proprioceptive movement control
    Authors: MN Khan, P Cherukuri, F Negro, A Rajput, P Fabrowski, V Bansal, C Lancelin, TI Lee, Y Bian, WP Mayer, T Akay, D Müller, S Bonn, D Farina, T Marquardt
    PloS Biology, 2022-12-21;20(12):e3001923.
    Species: Human
    Sample Types: Whole Cells
    Applications: IHC
  6. An Inverse Agonist GSK5182 Increases Protein Stability of the Orphan Nuclear Receptor ERRgamma via Inhibition of Ubiquitination
    Authors: SY Na, KS Kim, YS Jung, DK Kim, J Kim, SJ Cho, IK Lee, J Chung, JS Kim, HS Choi
    International Journal of Molecular Sciences, 2022-12-21;24(1):.
    Species: Human, Mouse
    Sample Types: Cell Lysates, Protein
    Applications: IHC, Immunoprecipitation
  7. Spinal Motoneuron TMEM16F Acts at C-boutons to Modulate Motor Resistance and Contributes to ALS Pathogenesis
    Authors: C Soulard, C Salsac, K Mouzat, C Hilaire, J Roussel, A Mezghrani, S Lumbroso, C Raoul, F Scamps
    Cell Rep, 2020-02-25;30(8):2581-2593.e7.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  8. Molecular Profiling Defines Evolutionarily Conserved Transcription Factor Signatures of Major Vestibulospinal Neuron Groups
    Authors: Anders Lunde, Benjamin W. Okaty, Susan M. Dymecki, Joel C. Glover
    eNeuro
  9. Origin and Segmental Diversity of Spinal Inhibitory Interneurons
    Authors: LB Sweeney, JB Bikoff, MI Gabitto, S Brenner-Mo, M Baek, JH Yang, EG Tabak, JS Dasen, CR Kintner, TM Jessell
    Neuron, 2018-01-04;0(0):.
    Species: Transgenic Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  10. Hypoxia Induces PDK4 Gene Expression through Induction of the Orphan Nuclear Receptor ERRgamma.
    Authors: Lee J, Kim E, Kim D, Lee J, Park S, Lee I, Harris R, Lee M, Choi H
    PLoS ONE, 2012-09-25;7(9):e46324.
    Species: Human
    Sample Types: Cell Lysates
    Applications: ChIP, Western Blot
  11. Estrogen-related receptor gamma (ERRgamma) is a novel transcriptional regulator of phosphatidic acid phosphatase, LIPIN1, and inhibits hepatic insulin signaling.
    Authors: Kim DK, Kim JR, Koh M, Kim YD, Lee JM, Chanda D, Park SB, Min JJ, Lee CH, Park TS, Choi HS
    J. Biol. Chem., 2011-09-12;286(44):38035-42.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  12. Esrrg functions in early branch generation of the ureteric bud and is essential for normal development of the renal papilla
    Authors: Rachel Berry, Louise Harewood, Liming Pei, Malcolm Fisher, David Brownstein, Allyson Ross et al.
    Human Molecular Genetics
  13. Transcriptional corepressor SMILE recruits SIRT1 to inhibit nuclear receptor estrogen receptor-related receptor gamma transactivation.
    Authors: Xie YB, Park JH, Kim DK, Hwang JH, Oh S, Park SB, Shong M, Lee IK, Choi HS
    J. Biol. Chem., 2009-08-18;284(42):28762-74.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation
  14. Activation of AMP-activated protein kinase by human EGF receptor 2/EGF receptor tyrosine kinase inhibitor protects cardiac cells.
    Authors: Spector NL, Yarden Y, Smith B, Lyass L, Trusk P, Pry K, Hill JE, Xia W, Seger R, Bacus SS
    Proc. Natl. Acad. Sci. U.S.A., 2007-06-07;104(25):10607-12.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  15. ERRgamma suppresses cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive prostate cancer cells and its implication as a therapeutic target for prostate cancer.
    Authors: Yu S, Wang X, Ng CF, Chen S, Chan FL
    Cancer Res., 2007-05-15;67(10):4904-14.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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