Human FCRN (NP_004098) VersaClone cDNA

Catalog #: RDC1817 Datasheet / COA / SDS

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RDC1817

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Human FCRN (NP_004098) VersaClone cDNA Summary

Specifications

Source

N/A

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species

Human

Product Datasheets

Product Datasheet

COA

SDS

Background: FCRN

FcRN (the neonatal Fc receptor) is a transmembrane MHC class I-like glycoprotein that is widely expressed on endothelial and epithelial cells. Mouse FcRN binds with high affinity to IgG from mouse, human, rat, rabbit, guinea pig, bovine, and sheep, while human FcRN binds IgG with significantly lower affinity and is much more restricted in terms of species recognition. It additionally binds to Albumin and beta 2-Microglobulin. FcRN is involved in recycling endocytosed IgG and Albumin, the bidirectional transport of IgG across epithelial and endothelial barriers, and intestinal uptake of maternal antibodies by the fetus. In the kidney, FcRN recycles Albumin to the serum but removes IgG from the glomular basement membrane and promotes its excretion into the urine. FcRN can also enhance IgG-mediated phagocytosis and antigen presentation by neutrophils and myeloid antigen presenting cells.

Long Name

Neonatal Fc Receptor

Entrez Gene IDs

2217 (Human); 14132 (Mouse); 29558 (Rat); 102128913 (Cynomolgus Monkey)

Alternate Names

alpha-chain; Fc fragment of IgG, receptor, transporter, alpha; FCGRT; FcRn alpha chain; FCRN; FCRNimmunoglobulin receptor, intestinal, heavy chain; IgG Fc fragment receptor transporter alpha chain; IgG receptor FcRn large subunit p51; major histocompatibility complex class I-like Fc receptor; Neonatal Fc receptor; neonatal Fc-receptor for Ig