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Human FPR1 PE-conjugated Antibody

Catalog #: FAB3744P
6 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB3744P
Detection of FPR1 in Human Monocytes by Flow Cytometry.
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Citations (6)
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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human FPR1 PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human FPR1. Stains human FPR1-transfected cells but not irrelevant transfectants.
Source
Monoclonal Mouse IgG2A Clone # 350418
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
HEK293 human embryonic kidney cell line transfected with human FPR1
Met1-Lys350
Accession # NP_002020
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of FPR1 antibody in Human Monocytes antibody by Flow Cytometry. View Larger

Detection of FPR1 in Human Monocytes by Flow Cytometry. Human monocytes were stained with Mouse Anti-Human FPR1 PE-conjugated Monoclonal Antibody (Catalog # FAB3744P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: FPR1

FPR1, FPRL1, and FPRL2 constitute a group of 7-transmembrane segment chemotactic receptors that are expressed on phagocytes. FPR1 binding of bacterial N‑formyl‑methionyl peptides draws neutrophils to sites of infection and promotes degranulation. In addition, a novel chemokine-like molecule, FAM19A4, has also been shown to bind to FPR1.  Human and mouse FPR1 share 73% amino acid sequence identity.

Long Name
Formyl Peptide Receptor 1
Entrez Gene IDs
2357 (Human); 14293 (Mouse); 292409 (Rat)
Alternate Names
fMet-Leu-Phe receptor; fMLF-R; fMLP receptor; FMLP; formyl peptide receptor 1; FPR1; FPRfMet-Leu-Phe receptor; N-formyl peptide receptor; N-formylpeptide chemoattractant receptor

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Citations for Human FPR1 PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

6 Citations: Showing 1 - 6
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  1. ALDH1L2 regulation of formate, formyl-methionine, and ROS controls cancer cell migration and metastasis
    Authors: Hennequart, M;Pilley, SE;Labuschagne, CF;Coomes, J;Mervant, L;Driscoll, PC;Legrave, NM;Lee, Y;Kreuzaler, P;Macintyre, B;Panina, Y;Blagih, J;Stevenson, D;Strathdee, D;Schneider-Luftman, D;Gr�nroos, E;Cheung, EC;Yuneva, M;Swanton, C;Vousden, KH;
    Cell reports
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay
  2. Application of small molecule FPR1 antagonists in the treatment of cancers
    Authors: DS Ahmet, HA Basheer, A Salem, D Lu, A Aghamohamm, P Weyerhäuse, A Bordiga, J Almeniawi, S Rashid, PA Cooper, SD Shnyder, V Vinader, K Afarinkia
    Sci Rep, 2020-10-14;10(1):17249.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  3. Regulation of the formyl peptide receptor 1 (FPR1) gene in primary human macrophages.
    Authors: Gemperle C, Schmid M, Herova M, Marti-Jaun J, Wuest S, Loretz C, Hersberger M
    PLoS ONE, 2012-11-21;7(11):e50195.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. The leukocyte chemotactic receptor FPR1 is functionally expressed on human lens epithelial cells.
    Authors: Schneider, Erich H, Weaver, Joseph D, Gaur, Sonia S, Tripathi, Brajendr, Jesaitis, Algirdas, Zelenka, Peggy S, Gao, Ji-Liang, Murphy, Philip M
    J Biol Chem, 2012-09-25;287(48):40779-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Severe congenital neutropenia resulting from G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis.
    Authors: McDermott DH, De Ravin SS, Jun HS
    Blood, 2010-07-08;116(15):2793-802.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. New insights into the phenotype of human dendritic cell populations.
    Authors: Clark GJ et al.
    Clin Transl Immunology

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