Human GPR50 (AAI03697) VersaClone cDNA

Catalog #: RDC0325 Datasheet / COA / SDS

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Human GPR50 (AAI03697) VersaClone cDNA Summary

Specifications

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species

Human

Product Datasheets

Product Datasheet

COA

SDS

Background: GPR50

GPR50, also known as MTR1L, is a nonglycosylated seven-transmembrane G protein-coupled receptor that is related to the melatonin receptors MT1 and MT2. GPR50 is expressed in the hippocampus, hypothalamus, and pituitary and forms 130 kDa homodimers. It heterodimerizes with either MT1 or MT2, resulting in inhibition of MT1 but not MT2 function. An alternately spliced isoform of GPR50 has a 4 aa deletion in the large C-terminal cytoplasmic domain. The presence of this deletion as well as various polymorphisms in GPR50 have been associated with elevated serum triglyceride and HDL levels. The deletion may also be associated with the development of bipolar disorder. Human GPR50 shares approximately 70% aa sequence identity with mouse and rat GPR50.

Long Name

G Protein-coupled Receptor 50

Entrez Gene IDs

9248 (Human); 14765 (Mouse); 117097 (Rat)

Alternate Names

G protein-coupled receptor 50H9Mel1c; GPR50; H9; melatonin-related receptor; MGC125342; MTR1L