Human HLA-C Alexa Fluor® 750-conjugated Antibody

Catalog #: FAB10394S Datasheet / COA / SDS

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FAB10394S-100UG

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Human HLA-C Alexa Fluor® 750-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human HLA-C in direct ELISAs.

Source

Monoclonal Mouse IgG Clone # DT-9

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Purified tamarin MHC class I molecules (using anti-class I antibody BB7.7)
Accession # P10321

Formulation

Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Label

Alexa Fluor 750 (Excitation= 749 nm, Emission= 775 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

0.25-1 µg/10⁶ cells

Human PBMC Lymphocytes

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: HLA-C

HLA-A, B, and C are approximately 45 kDa transmembrane glycoproteins in the major histocompatibility complex 1 (MHC I) family. They contain three alpha domains in their extracellular regions. HLA molecules are expressed on nearly all nucleated cells in association with the 12 kDa beta 2-Microglobulin. This complex binds peptides derived from pathogenic cytosolic or extracellular proteins such as viral or microbial proteins. It presents these peptides on the cell surface for recognition by the T cell receptor on CD8+ cytotoxic T cells. The activated cytotoxic T cell then kills the presenting cell. Mismatched MHC I alleles between a host and a donor lead to transplant rejection.

Long Name

Major Histocompatibility Complex, Class I, C

Entrez Gene IDs

3107 (Human)

Alternate Names

C alpha chain; D6S204; FLJ27082; HLA class I histocompatibility antigen, Cw-1 alpha chain; HLAC; HLA-C; HLA-Cw; HLA-JY3; HLC-C; human leukocyte antigen-C alpha chain; leucocyte antigen C; leucocyte antigen Cw; leukocyte antigen-C alpha chain; major histocompatibility antigen HLA-C; major histocompatibility complex, class I, C; MHC class I antigen Cw*1; MHC class I antigen Cw*12; MHC class I antigen Cw*14; MHC class I antigen Cw*15; MHC class I antigen Cw*16; MHC class I antigen Cw*17; MHC class I antigen Cw*2; MHC class I antigen Cw*3; MHC class I antigen Cw*4; MHC class I antigen Cw*5; MHC class I antigen Cw*6; MHC class I antigen Cw*7; MHC class I antigen Cw*8; MHC class I antigen heavy chain HLA-C; PSORS1

Product Datasheets

Product Datasheet

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SDS

Product Specific Notices

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.