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Human IFN-alpha/beta R2 MAb (Clone MMHAR-2)

Catalog #: 21385-1
5 Citations Datasheet / COA / SDS

Discontinued Product

21385-1 has been discontinued.
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Citations (5)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human IFN-alpha/beta R2 MAb (Clone MMHAR-2) Summary

Species Reactivity
Human
Source
Monoclonal Mouse IgG2a Clone # MMHAR-2
Label
Unconjugated

Applications

Recommended Concentration
Sample
Neutralization

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: IFN-alpha/beta R2

IFN-alpha/beta R2, also known as IFNAR2, is a 100 kDa component of the class II cytokine receptor that binds the type I interferons IFN-alpha, IFN-beta, and IFN-omega. IFN-alpha/beta R2 associates with the 125 kDa IFN-alpha/beta R1 component to form a receptor complex that transmits antiviral and antiproliferative signals. Down-regulation of the receptor is accomplished by ubiquitination and degradation. A soluble form of the protein, corresponding to the extracellular ligand-binding domain, is generated by alternative splicing.

Long Name
Interferon alpha/beta Receptor 2
Entrez Gene IDs
3455 (Human); 15976 (Mouse); 102140083 (Cynomolgus Monkey)
Alternate Names
beta receptor10; human interferon alpha; human interferon alpha/beta receptor; IFNABR; IFN-alpha binding protein; IFN-alpha/beta R2; IFN-alpha/beta receptor 2; IFN-alpha-REC; IFNAR2; IFN-aR2; IFNARB; IFNbR2; IFN-bR2; IFN-R; IFN-R-2; interferon (alpha, beta and omega) receptor 2; Interferon alpha binding protein; interferon alpha/beta receptor 2; interferon-alpha/beta receptor beta chain; Type I interferon receptor 2

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Citations for Human IFN-alpha/beta R2 MAb (Clone MMHAR-2)

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Type I Interferons Suppress Anti-parasitic Immunity and Can Be Targeted to Improve Treatment of Visceral Leishmaniasis
    Authors: R Kumar, PT Bunn, SS Singh, SS Ng, M Montes de, F De Labasti, SB Chauhan, N Singh, RJ Faleiro, CL Edwards, TCM Frame, M Sheel, RJ Austin, SW Lane, T Bald, MJ Smyth, GR Hill, SE Best, A Haque, D Corvino, N Waddell, L Koufarioti, P Mukhopadha, M Rai, J Chakravart, OP Singh, D Sacks, S Nylen, J Uzonna, S Sundar, CR Engwerda
    Cell Rep, 2020-02-25;30(8):2512-2525.e9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  2. Uterine epithelial cells specifically induce interferon-stimulated genes in response to polyinosinic-polycytidylic acid independently of estradiol.
    Authors: Patel MV, Ghosh M, Fahey JV, Wira CR
    PLoS ONE, 2012-04-25;7(4):e35654.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  3. Neutralizing type I IFN antibodies trigger an IFN-like response in endothelial cells.
    Authors: Moll HP, Freudenthaler H, Zommer A
    J. Immunol., 2008-04-15;180(8):5250-6.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  4. TLR7 Agonist 852A Inhibition of Tumor Cell Proliferation Is Dependent on Plasmacytoid Dendritic Cells and Type I IFN.
    Authors: Inglefield JR, Dumitru CD, Alkan SS, Gibson SJ, Lipson KE, Tomai MA, Larson CJ, Vasilakos JP
    J. Interferon Cytokine Res., 2008-04-01;28(4):253-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  5. Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist.
    Authors: Best SM, Morris KL, Shannon JG, Robertson SJ, Mitzel DN, Park GS, Boer E, Wolfinbarger JB, Bloom ME
    J. Virol., 2005-10-01;79(20):12828-39.
    Species: Primate - Chlorocebus pygerythrus (Vervet Monkey)
    Sample Types: Cell Lysates
    Applications: Immunoprecipitation

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