Human IFN-beta Antibody

Catalog #: 21465-1 Datasheet / COA / SDS

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21465-1

All IFN-beta Antibodies

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Human IFN-beta Antibody Summary

Species Reactivity

Human

Specificity

Binds to human interferon beta with high affinity. The ND₅₀ for this antibody on human (A549/EMCV) cells is ~27-66 μg/ml in the presence of 96 pg/ml of recombinant human interferon beta 1a, mammalian.

Source

Monoclonal Mouse IgG_2B Clone # MMHB-15

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Human interferon beta

Formulation

Phosphate buffered saline (PBS) containing 0.1% bovine serum albumin (BSA)

Label

Unconjugated

Applications

Recommended Concentration

Sample

Direct ELISA

Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

After receipt, the product may be stored at -20°C for short-term use (≤ 6 months). For
long-term storage, we recommend storing the product at -70°C or below for retention of full activity. When thawing, the
contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum.
Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers
containing protein such as 0.1% bovine serum albumin (BSA).

Background: IFN-beta

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Long Name

Interferon beta

Entrez Gene IDs

3456 (Human); 15977 (Mouse); 24481 (Rat)

Alternate Names

Fibroblast interferon; IFB; IFBIFNB; IFF; IFNB; IFNB1; IFNbeta; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956