Human IL-1 RI Fluorescein-conjugated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
View Larger
Detection of IL‑1 RI in HUVEC Human Cells by Flow Cytometry. HUVEC human umbilical vein endothelial cells were stained with Goat Anti-Human IL-1 RI Fluorescein-conjugated Antigen Affinity-purified Polyclonal Antibody (Catalog # FAB269F, filled histogram) or control antibody (Catalog # IC108F, open histogram). View our protocol for Staining Membrane-associated Proteins.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: IL-1 RI
Two distinct types of receptors that bind the pleiotropic cytokines IL-1 alpha and IL-1 beta have been described. The IL-1 receptor Type I is an 80 kDa transmembrane protein that is expressed predominantly by T cells, fibroblasts, and endothelial cells. IL-1 receptor Type II is a 68 kDa transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. Both receptors are members of the immunoglobulin superfamily and show approximately 28% sequence identity in their extracellular domains. The two receptor types do not heterodimerize into a receptor complex.
An IL-1 receptor accessory protein that can heterodimerize with the Type I receptor in the presence of IL-1 alpha or IL-1 beta but not IL-1ra, was identified (1). This Type I receptor complex appears to mediate all the known IL-1 biological responses. The receptor Type II has a short cytoplasmic domain and does not transduce IL-1 signals. In addition to the membrane-bound form of IL-1 RII, a naturally-occurring soluble form of IL-1 RII has been described. It has been suggested that the Type II receptor, either as the membrane-bound or as the soluble form, serves as a decoy for IL-1 and inhibits IL-1 action by blocking the binding of IL-1 to the signaling Type I receptor complex. Recombinant IL-1 soluble receptor Type I is a potent antagonist of IL-1 action.
Product Datasheets
Citations for Human IL-1 RI Fluorescein-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
9
Citations: Showing 1 - 9
Filter your results:
Filter by:
-
Tranilast Directly Targets NLRP3 to Protect Melanocytes From Keratinocyte-Derived IL-1 beta Under Oxidative Stress
Authors: Tongtian Zhuang, Shuli Li, Xiuli Yi, Sen Guo, Yinghan Wang, Jianru Chen et al.
Frontiers in Cell and Developmental Biology
-
Ocular Fibroblast Diversity: Implications for Inflammation and Ocular Wound Healing
Authors: Xia Xi, David H. McMillan, Geniece M. Lehmann, Patricia J. Sime, Richard T. Libby, Krystel R. Huxlin et al.
Investigative Opthalmology & Visual Science
-
Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg-Th17 Plasticity in Periodontitis.
Authors: Mythilypriya Rajendran, Stephen Looney, Nagendra Singh, Mahmoud Elashiry, Mohamed M. Meghil, Ahmed R. El-Awady et al.
The Journal of Immunology
-
Zinc transport from the endoplasmic reticulum to the cytoplasm via Zip7 is necessary for barrier dysfunction mediated by inflammatory signaling in RPE cells
Authors: Y Xu, M Twarog, N Li, A Banks, J Schustak, Y Bao, Q Huang, QG Medley
PLoS ONE, 2022-07-28;17(7):e0271656.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
TNF-alpha and IL-1beta sensitize human MSC for IFN-gamma signalling and enhance neutrophil recruitment
Authors: A Hackel, A Aksamit, K Bruderek, S Lang, S Brandau
Eur. J. Immunol., 2020-09-24;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Comparing the Effects of the mTOR Inhibitors Azithromycin and Rapamycin on In Vitro Expanded Regulatory T Cells
Authors: M Bergström, M Müller, M Karlsson, H Scholz, NT Vethe, O Korsgren
Cell Transplant, 2019-09-12;0(0):9636897198724.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion.
Authors: Zhang Z, Cheng L, Zhao J, Li G, Zhang L, Chen W, Nie W, Reszka-Blanco N, Wang F, Su L
J Clin Invest, 2015-08-24;125(9):3692-703.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis.
Authors: Zhang X, Tao Y, Chopra M, Dujmovic-Basuroski I, Jin J, Tang Y, Drulovic J, Markovic-Plese S
J Immunol, 2015-04-20;194(11):5139-49.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Regulating human Th17 cells via differential expression of IL-1 receptor.
Authors: Lee WW, Kang SW, Choi J
Blood, 2009-11-12;115(3):530-40.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsReviews for Human IL-1 RI Fluorescein-conjugated Antibody
Average Rating: 5 (Based on 1 Review)
Have you used Human IL-1 RI Fluorescein-conjugated Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
