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Human IL-17 Quantikine ELISA Kit

Catalog #: D1700
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Human IL-17/IL-17A ELISA Cell Culture Supernate Standard Curve
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Summary Precision Recovery Linearity Data Examples Product Datasheets Preparation and Storage Background Related Research Areas

Human IL-17 Quantikine ELISA Kit Summary

Assay Type
Solid Phase Sandwich ELISA
Format
96-well strip plate
Assay Length
4.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (100 uL), Serum (100 uL), EDTA Plasma (100 uL), Heparin Plasma (100 uL), Citrate Plasma (100 uL)
Sensitivity
15 pg/mL
Assay Range
31.2 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma)
Specificity
Natural and recombinant human IL-17
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Product Summary

The Quantikine Human IL-17 Immunoassay is a 4.5 hour solid phase ELISA designed to measure human IL-17 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IL-17 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate recombinant human IL-17 accurately. Results obtained using natural human IL-17 showed linear curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IL-17.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (pg/mL) 107 604 1217 76.6 272 549
Standard Deviation 7.8 25 63.3 6.5 23.4 43.9
CV% 7.3 4.1 5.2 8.5 8.6 8

Serum, EDTA Plasma, Heparin Plasma, Citrate Plasma

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean (pg/mL) 131 736 1480 125 408 794
Standard Deviation 5.8 34.6 61.2 9.8 34.3 55.6
CV% 4.4 4.7 4.1 7.8 8.4 7

Recovery

The recovery of human IL-17 spiked to three different levels throughout the range of the assay in various matrices was evaluated.

Sample Type Average % Recovery Range %
Cell Culture Media (n=5) 97 88-112
Citrate Plasma (n=5) 105 92-116
EDTA Plasma (n=5) 101 90-110
Heparin Plasma (n=5) 101 93-109
Serum (n=5) 98 90-105

Linearity

To assess the linearity of the assay, five samples spiked with high concentrations of IL-17 were diluted with the appropriate Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Human IL-17/IL-17A ELISA Linearity

Scientific Data

N/A Human IL-17/IL-17A ELISA Cell Culture Supernate Standard Curve View Larger

Human IL-17/IL-17A ELISA Cell Culture Supernate Standard Curve

N/A Human IL-17/IL-17A ELISA Serum/Plasma Standard Curve View Larger

Human IL-17/IL-17A ELISA Serum/Plasma Standard Curve

Product Datasheets

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IL-17/IL-17A

Human Interleukin 17 (IL-17), also known as IL-17A and CTLA-8, is a 15-20 kDa, variably glycosylated polypeptide that belongs to the IL-17 family of cytokines (1-5). Its alternate name, CTLA-8, originated from rodent studies where an activated hybridoma was created from the fusion of a mouse cytotoxic and a rat T cell lymphoma cell line. The molecule of interest in this study was assumed to have come from the mouse cytotoxic lymphocyte cell (thus the CTL designation), whereas, in fact, it was a rat lymphocyte molecule. Human IL-17/17A is synthesized as a 155 amino acid (aa) precursor that contains a 23 aa signal sequence and a 133 aa mature region that possesses a cysteine-knot fold (4-6). In both human and mouse, there is one conserved N-linked glycosylation site that likely contributes 5 kDa to its native molecular weight. IL-17A forms both a 32-38 kDa disulfide-linked homodimer, and a 40-45 kDa covalent heterodimer with IL-17F (7-9). Most secreted IL-17A is in the form of the IL-17A:F heterodimer, however, the IL-17A:A homodimer is the most bioactive of the two forms (8). Mature human IL-17A is 61%, 74%, and 99% aa identical to mouse, porcine, and chimpanzee IL-17A, respectively (10-12). Mammalian cells known to produce IL-17 are the CD4+ Th17 T cells, Paneth cells, GR1+CD11b+ myeloid suppressor cells, CD27- gamma δ T cells, CD1+NK1.1- iNKT cells, and CD3- CD4+ LTi-like cells (9, 13-17). 

A high affinity receptor for human IL-17 has been reported, and appears to be a heteromultimer of IL-17RA and IL-17RC, likely in a 2:1 ratio (1, 18). IL-17RA is a 130 kDa, type I transmembrane glycoprotein that bears no resemblance to members of the cytokine, TNF or immunoglobulin receptor superfamily (2, 10, 15). IL-17RC is also a type I transmembrane protein, approximately 90-95 kDa in size, that shares less than 30% aa identity with IL-17RA (19, 20). Both receptors are needed for IL-17A and IL-17A:F activity. The two receptors appear to form a functional association following ligand binding to IL-17RA (1, 21, 22). 
IL-17 is best known for its participation in the recruitment and survival of neutrophils (14, 15, 23, 24, 25). Its induction was initially described to be the result of antigen stimulation of dendritic cells, resulting in IL-23 secretion. In a T cell receptor-independent event, IL-23 induces T cell production of IL-17 (14). Once secreted, IL-17 in the bone marrow would seem to induce stromal/fibroblast expression of both G-CSF and stem cell factor (membrane form), an effect that increases polymorphonuclear neutrophils (PMN) differentiation and production. IL-17 may complement this by directly blocking neutrophil apoptosis, promoting greater circulating PMN numbers (23). In the tissues, IL-17 would also seem to promote neutrophil extravasation, principally through its effects on macrophages and endothelial cells (EC). On macrophages, IL-17 induces TNF-alpha, IL-1b and IL-6 production (26). TNF-alpha and IL-1b then act on local ECs to induce G-CSF secretion, an effect that is potentiated by IL-17 (27). IL-17 further contributes to PMN influx by inducing EC CXC chemokine release and NO production, which may increase vascular permeability (14, 28). IL-17 effects are not limited to inflammation. In synovial joints, IL-17 upregulates RANKL expression on osteoblasts. This provides a stimulus for osteoclast formation and subsequent bone resorption (24). In conjunction with IL-4 and CD40L, IL-17A also promotes the generation of IgE secreting cells (29). And in white fat, IL-17A inhibits adipocyte differentiation from preadipocytes, and impairs glucose uptake by mature adipocytes (30).

Long Name:
Interleukin 17
Entrez Gene IDs:
3605 (Human); 16171 (Mouse); 301289 (Rat); 449530 (Porcine); 481837 (Canine); 102119976 (Cynomolgus Monkey)
Alternate Names:
CTLA8; CTLA-8; CTLA8cytotoxic T-lymphocyte-associated serine esterase 8; Cytotoxic T-lymphocyte-associated antigen 8; IL17; IL-17; IL17A; IL-17A; IL-17Acytotoxic T-lymphocyte-associated protein 8; IL-17CTLA-8; IL17interleukin-17A; interleukin 17 (cytotoxic T-lymphocyte-associated serine esterase 8); interleukin 17A
&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Assay Procedure

Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.
    3. 100 µL Assay Diluent
  3.   Add 100 µL of Assay Diluent to each well.
    4. 100 µL Standard, Control, or Sample
  4.   Add 100 µL of Standard, control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 3 hours.
  5.   Aspirate each well and wash, repeating the process twice for a total of 3 washes.
    6. 200 µL Conjugate
  6.   Add 200 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 1 hour.
  7.   Aspirate and wash 3 times.
    8. 200 µL Substrate Solution
  8.   Add 200 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.
    9. 50 µL Stop Solution
  9.   Add 50 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.

Citations for Human IL-17 Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

95 Citations: Showing 1 - 10
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  1. Evaluation of the Activity of Cardiac Glycosides on ROR? and ROR?T Nuclear Receptors
    Authors: Karwaciak, I;Pastwi?ska, J;Sa?kowska, A;Bachorz, RA;Ratajewski, M;
    Archives of biochemistry and biophysics
    Species: Human
    Sample Types: Cell Culture Supernates
  2. Cytokine expression profiles in children and adolescents with tic disorders
    Authors: Kutuk, MO;Tufan, AE;Kilicaslan, F;Gokcen, C;Aksu, GG;Yektas, C;Kandemir, H;Celik, F;Mutluer, T;Buber, A;Karadag, M;Coban, N;Coskun, S;Hangul, Z;Altintas, E;Acikbas, U;Giray, A;Aka, Y;Basturk, B;Kutuk, O;
    Scientific reports
    Species: Human
    Sample Types: Serum
  3. A Comparative Analysis of Innate Immune Responses and the Structural Characterization of Spike from SARS-CoV-2 Gamma Variants and Subvariants
    Authors: Scovino, AM;Dahab, EC;Diniz-Lima, I;de Senna Silveira, E;Barroso, SPC;Cardoso, KM;Nico, D;Makhoul, GJ;da Silva-Junior, EB;Freire-de-Lima, CG;Freire-de-Lima, L;Fonseca, LMD;Valente, N;Nacife, V;Machado, A;Araújo, M;Vieira, GF;Pauvolid-Corrêa, A;Siqueira, M;Morrot, A;
    Microorganisms
    Species: Human
    Sample Types: Cell Culture Supernates
  4. Inflammaging and body composition: New insights in diabetic and hypertensive elderly men
    Authors: CV Gonçalves, IS Ribeiro, MPL Galantini, IPR Muniz, PHB Lima, GS Santos, RAA da Silva
    Experimental gerontology, 2022-10-28;170(0):112005.
    Species: Human
    Sample Types: Serum
  5. Potential Protective Role of Galectin-3 in Patients with Gonarthrosis and Diabetes Mellitus: A Cross-Sectional Study
    Authors: J Milosevic, M Jurisevic, V Grbovic, I Jovanovic, N Gajovic, A Jurisic-Sk
    International Journal of Environmental Research and Public Health, 2022-09-13;19(18):.
    Species: Human
    Sample Types: Serum
  6. The sweet fuel of inflammation: New perspectives on the complex web that interconnects diabetes
    Authors: MPL Galantini, IS Ribeiro, CV Gonçalves, IPR Muniz, PHB Lima, GS Santos, RAA da Silva
    Experimental gerontology, 2022-07-30;167(0):111905.
    Species: Human
    Sample Types: Serum
  7. The Mechanism of Inflammatory Factors and Soluble Vascular Cell Adhesion Molecule-1 Regulated by Nuclear Transcription Factor NF-kappaB in Unstable Angina Pectoris
    Authors: Q Su, L Zhang, Z Qi, B Huang
    Journal of Immunology Research, 2022-07-30;2022(0):6137219.
    Species: Human
    Sample Types: Serum
  8. Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus
    Authors: S Luo, R Wu, Q Li, G Zhang
    Journal of Immunology Research, 2022-05-10;2022(0):4053038.
    Species: Human
    Sample Types: Serum
  9. Chemokine Expression-Based Endotype Clustering of Chronic Rhinosinusitis
    Authors: U Förster-Ru, AJ Szczepek, G Pierchalla, JW Fluhr, M Artuc, T Zuberbier, C Bachert, H Olze
    Journal of personalized medicine, 2022-04-18;12(4):.
    Species: Human
    Sample Types: Tissue
  10. Identification of Corosolic and Oleanolic Acids as Molecules Antagonizing the Human RORgammaT Nuclear Receptor Using the Calculated Fingerprints of the Molecular Similarity
    Authors: J Pastwi?ska, K Kara?, A Sa?kowska, I Karwaciak, K Cha?a?kiew, BA Wojtczak, RA Bachorz, M Ratajewski
    International Journal of Molecular Sciences, 2022-02-08;23(3):.
    Species: Human
    Sample Types: Cell Culture Supernates
  11. Vitamin D modulates the transcription factors of T cell subsets to anti-inflammatory and regulatory profiles in preeclampsia
    Authors: VR Ribeiro, M Romao-Veig, PR Nunes, ML Matias, JC Peracoli, MTS Peracoli
    International immunopharmacology, 2021-11-20;0(0):108366.
    Species: Human
    Sample Types: Cell Culture Supernates
  12. Phenotypic characterization of NKT-like cells and evaluation of specifically related cytokines for the prediction of unexplained recurrent miscarriage
    Authors: WS Khalaf, MRA Mahmoud, WF Elkhatib, HR Hashem, WE Soliman
    Heliyon, 2021-11-16;7(11):e08409.
    Species: Human
    Sample Types: Serum
  13. Serum Interleukin (IL)-23 and IL-17 Profile in Inflammatory Bowel Disease (IBD) Patients Could Differentiate between Severe and Non-Severe Disease
    Authors: LA Lucaciu, M Ilie?, ?C Vesa, R Seicean, S Din, CA Iuga, A Seicean
    Journal of personalized medicine, 2021-11-02;11(11):.
    Species: Human
    Sample Types: Serum
  14. Regular physical activity reduces the effects of inflammaging in diabetic and hypertensive men
    Authors: IS Ribeiro, ÍS Pereira, MPL Galantini, DP Santos, MF Teles, IPR Muniz, GS Santos, RAA Silva
    Experimental gerontology, 2021-09-20;155(0):111558.
    Species: Human
    Sample Types: Plasma
  15. The relationship of long non-coding RNA maternally expressed gene 3 with microRNA-21 and their correlation with acute ischemic stroke risk, disease severity and recurrence risk
    Authors: C Liu, H Huang, Y Li, H Zhao
    Clinical neurology and neurosurgery, 2021-09-11;210(0):106940.
    Species: Human
    Sample Types: Cell Culture Supernates
  16. Expression of Jejunal Taste Receptors in Women with Morbid Obesity
    Authors: L Bertran, M Portillo-C, S Martínez, C Aguilar, M Lopez-Dupl, D Riesco, J Binetti, M Vives, F Sabench, D Del Castil, C Richart, T Auguet
    Nutrients, 2021-07-16;13(7):.
    Species: Human
    Sample Types: Serum
  17. Association of Sarcopenia and Gut Microbiota Composition in Older Patients with Advanced Chronic Kidney Disease, Investigation of the Interactions with Uremic Toxins, Inflammation and Oxidative Stress
    Authors: E Margiotta, L Caldiroli, ML Callegari, F Miragoli, F Zanoni, S Armelloni, V Rizzo, P Messa, S Vettoretti
    Toxins, 2021-07-08;13(7):.
    Species: Human
    Sample Types: Serum
  18. Inhibition of IL-17 prevents the progression of traumatic heterotopic ossification
    Authors: B Tu, B Yu, W Wang, J Li, F Yuan, J Zhu, C Fan
    Journal of Cellular and Molecular Medicine, 2021-06-29;0(0):.
    Species: Human
    Sample Types: Serum
  19. Regular physical activity reduces the proinflammatory response in older women with diabetes and hypertension in the postmenopausal phase
    Authors: DPS Lopes, IS Ribeiro, DC Santos, FMS Lima, AA Santos, DSP Souza, DN Lopes, AO Prado, ÍS Pereira, DP Santos, GS Santos, RAA Silva
    Experimental gerontology, 2021-06-11;152(0):111449.
    Species: Human
    Sample Types: Plasma
  20. The YAP/HIF-1&alpha/miR-182/EGR2 axis is implicated in asthma severity through the control of Th17 cell differentiation
    Authors: J Zhou, N Zhang, W Zhang, C Lu, F Xu
    Cell & bioscience, 2021-05-12;11(1):84.
    Species: Human
    Sample Types: Serum
  21. Porphyromonas gingivalis lipopolysaccharide promotes T-hel per17 cell differentiation by upregulating Delta-like ligand 4 expression on CD14+ monocytes
    Authors: C Zhang, C Xu, L Gao, X Li, C Zhao
    PeerJ, 2021-04-23;9(0):e11094.
    Species: Human
    Sample Types: Cell Culture Supernates
  22. Cytokine Profiles of Non-Small Cell Lung Cancer Patients Treated with Concurrent Chemoradiotherapy with Regards to Radiation Pneumonitis Severity
    Authors: BK Jeong, JH Kim, MH Jung, KM Kang, YH Lee
    Journal of Clinical Medicine, 2021-02-11;10(4):.
    Species: Human
    Sample Types: Plasma
  23. Tumor exosome promotes Th17 cell differentiation by transmitting the lncRNA CRNDE-h in colorectal cancer
    Authors: J Sun, H Jia, X Bao, Y Wu, T Zhu, R Li, H Zhao
    Cell Death & Disease, 2021-01-25;12(1):123.
    Species: Human
    Sample Types: Cell Culture Supernates
  24. Inflammatory versus Anti-inflammatory Profiles in Major Depressive Disorders-The Role of IL-17, IL-21, IL-23, IL-35 and Foxp3
    Authors: M Ga?ecka, K Bli?niewsk, A Orzechowsk, J Szemraj, M Maes, M Berk, KP Su, P Ga?ecki
    Journal of personalized medicine, 2021-01-23;11(2):.
    Species: Human
    Sample Types: Serum
  25. Peritoneal dialysate-range hypertonic glucose promotes T cell IL-17 production that induces mesothelial inflammation
    Authors: A Helmke, AM Hüsing, S Gaedcke, N Brauns, MS Balzer, M Reinhardt, M Hiss, N Shushakova, D de Luca, I Prinz, H Haller, S von Vietin
    Eur. J. Immunol., 2020-09-30;0(0):.
    Species: Human
    Sample Types: Serum
  26. Increased Serum Level and High Tissue Immunoexpression of Interleukin 17 in Cutaneous Lichen Planus: A Novel Therapeutic Target for Recalcitrant Cases?
    Authors: M ?ychowska, A Batycka-Ba, W Baran
    Dis. Markers, 2020-07-24;2020(0):6521274.
    Species: Human
    Sample Types: Serum
  27. Identification of Novel Molecular Markers of Human Th17 Cells
    Authors: A Sa?kowska, K Kara?, I Karwaciak, A Walczak-Dr, M Krawczyk, M Sobalska-K, J Dastych, M Ratajewski
    Cells, 2020-07-03;9(7):.
    Species: Human
    Sample Types: Cell Culture Supernates
  28. Cytokine expression profiles in Autism spectrum disorder: A multi-center study from Turkey
    Authors: MO Kutuk, E Tufan, C Gokcen, F Kilicaslan, M Karadag, T Mutluer, C Yektas, N Coban, H Kandemir, A Buber, S Coskun, U Acikbas, G Guler, Z Topal, F Celik, E Altintas, A Giray, Y Aka, O Kutuk
    Cytokine, 2020-06-18;133(0):155152.
    Species: Human
    Sample Types: Serum
  29. Relationship between IL-8 Circulating Levels and TLR2 Hepatic Expression in Women with Morbid Obesity and Nonalcoholic Steatohepatitis
    Authors: T Auguet, L Bertran, J Binetti, C Aguilar, S Martínez, F Sabench, JM Lopez-Dupl, JA Porras, D Riesco, D Del Castil, C Richart
    Int J Mol Sci, 2020-06-11;21(11):.
    Species: Human
    Sample Types: Plasma
  30. lncRNA CASC2 downregulation participates in rheumatoid arthritis, and CASC2 overexpression promotes the apoptosis of fibroblast?like synoviocytes by downregulating IL?17
    Authors: C Liu, X Guo, S Bai, G Zeng, H Wang
    Mol Med Rep, 2020-03-10;0(0):.
    Species: Human
    Sample Types: Plasma
  31. Circulating IL-17A Levels in Postmenopausal Women with Primary Hyperparathyroidism
    Authors: E Dozio, E Passeri, E Vianello, S Palmieri, C Eller-Vain, M Corsi Roma, S Corbetta
    Mediators Inflamm., 2020-01-17;2020(0):3417329.
    Species: Human
    Sample Types: Plasma
  32. TH17 cells�expressing CD146 are significantly increased in patients with Systemic sclerosis
    Authors: A Gabsi, X Heim, A Dlala, A Gati, H Sakhri, A Abidi, S Amri, B Neili, AS Leroyer, A Bertaud, M Smiti Khan, F Said, MH Houman, B Granel, M Blot-Chaba, N Bardin, R Marrakchi
    Sci Rep, 2019-11-27;9(1):17721.
    Species: Human
    Sample Types: Serum
  33. Association between body composition and inflammation: A central role of IL-17 and IL-10 in diabetic and hypertensive elderly women
    Authors: IS Ribeiro, ÍS Pereira, DP Santos, DS Lopes, AO Prado, SPM Calado, CV Gonçalves, MPL Galantini, IPR Muniz, GS Santos, RAA Silva
    Exp. Gerontol., 2019-09-10;127(0):110734.
    Species: Human
    Sample Types: Plasma
  34. Sarcopenia is Associated with Malnutrition but Not with Systemic Inflammation in Older Persons with Advanced CKD
    Authors: S Vettoretti, L Caldiroli, S Armelloni, C Ferrari, M Cesari, P Messa
    Nutrients, 2019-06-19;11(6):.
    Species: Human
    Sample Types: Serum
  35. Mesangial Cells Exhibit Features of Antigen-Presenting Cells and Activate CD4+ T Cell Responses
    Authors: H Yu, S Cui, Y Mei, Q Li, L Wu, S Duan, G Cai, H Zhu, B Fu, L Zhang, Z Feng, X Chen
    J Immunol Res, 2019-06-17;2019(0):2121849.
    Species: Human
    Sample Types: Cell Culture Supernates
  36. Effects of early enteral nutrition on Th17/Treg cells and IL-23/IL-17 in septic patients
    Authors: JK Sun, WH Zhang, WX Chen, X Wang, XW Mu
    World J. Gastroenterol., 2019-06-14;25(22):2799-2808.
    Species: Human
    Sample Types: Serum
  37. Targetable mechanisms driving immunoevasion of persistent senescent cells link chemotherapy-resistant cancer to aging
    Authors: DP Muñoz, SM Yannone, A Daemen, Y Sun, F Vakar-Lope, M Kawahara, AM Freund, F Rodier, JD Wu, PY Desprez, DH Raulet, PS Nelson, LJ van 't Vee, J Campisi, JP Coppé
    JCI Insight, 2019-06-11;5(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  38. LncRNA�CASC2 is upregulated in osteoarthritis and participates in the regulation of IL-17 expression and chondrocyte proliferation and apoptosis
    Authors: T Huang, J Wang, Y Zhou, Y Zhao, D Hang, Y Cao
    Biosci. Rep., 2019-05-14;0(0):.
    Species: Human
    Sample Types: Plasma
  39. Plasma levels of TNF-?, IL-6, IFN-?, IL-12, IL-17, IL-22, and IL-23 in achalasia, eosinophilic esophagitis (EoE), and gastroesophageal reflux disease (GERD)
    Authors: S Clayton, E Cauble, A Kumar, N Patil, D Ledford, N Kolliputi, MF Lopes-Vire, D Castell, J Richter
    BMC Gastroenterol, 2019-02-11;19(1):28.
    Species: Human
    Sample Types: Plasma
  40. Digoxin, an Overlooked Agonist of ROR?/ROR?T
    Authors: K Kara?, A Sa?kowska, M Sobalska-K, A Walczak-Dr, D Strapagiel, J Dastych, RA Bachorz, M Ratajewski
    Front Pharmacol, 2019-01-07;9(0):1460.
    Species: Human
    Sample Types: Cell Culture Supernates
  41. VSIG-3 as a ligand of VISTA inhibits human T-cell function.
    Authors: Wang J, Wu G, Manick B, Hernandez V, Renelt M, Erickson C, Guan J, Singh R, Rollins S, Solorz A, Bi M, Li J, Grabowski D, Dirkx J, Tracy C, Stuart T, Ellinghuysen C, Desmond D, Foster C, Kalabokis V
    Immunology, 2018-10-10;156(1):74-85.
    Species: Human
    Sample Types: Cell Culture Supernates
  42. IL-17A-associated IKK-? signaling induced TSLP production in epithelial cells of COPD patients
    Authors: G Anzalone, GD Albano, AM Montalbano, L Riccobono, A Bonanno, R Gagliardo, F Bucchieri, R Marchese, M Moscato, M Profita
    Exp. Mol. Med., 2018-10-05;50(10):131.
    Species: Human
    Sample Types: Sputum Supernates
  43. Decreased interleukin-11 levels in the semen of infertile males
    Authors: L Qian
    Cytokine, 2018-03-22;108(0):57-59.
    Species: Human
    Sample Types: Semen
  44. Serum levels of IL-17 are elevated in patients with acute gouty arthritis
    Authors: Y Liu, Q Zhao, Y Yin, MA McNutt, T Zhang, Y Cao
    Biochem. Biophys. Res. Commun., 2018-03-11;497(3):897-902.
    Species: Human
    Sample Types: Serum
  45. BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity
    Authors: RJW Arts, SJCFM Moorlag, B Novakovic, Y Li, SY Wang, M Oosting, V Kumar, RJ Xavier, C Wijmenga, LAB Joosten, CBEM Reusken, CS Benn, P Aaby, MP Koopmans, HG Stunnenber, R van Crevel, MG Netea
    Cell Host Microbe, 2018-01-10;23(1):89-100.e5.
    Species: Human
    Sample Types: Cell Culture Supernates
  46. Rheumatoid arthritis bone marrow environment supports Th17 response.
    Authors: Ewa Kuca-Warna, Weronika Kurowska, Monika Prochorec, Anna Radzikows, Tomasz Burakowsk, Urszula Skalska, Magdalena Massalska, Magdalena Pleba?czy, Barbara Ma?dyk-No, Iwona S?owi?ska, Robert Gasik, W?odzimierz Ma?li?ski
    Arthritis Research & Therapy, 2017-12-08;0(0):1478-6362.
    Species: Human
    Sample Types: Cell Culture Supernates
  47. T cell activation and differentiation is modulated by a CD6 domain 1 antibody Itolizumab
    Authors: U Bughani, A Saha, A Kuriakose, R Nair, RB Sadashivar, R Venkataram, S Patel, AT Deshchougu, SK S, E Montero, HV Pai, DV Palanivelu, R Melarkode, P Nair
    PLoS ONE, 2017-07-03;12(7):e0180088.
    Species: Human
    Sample Types: Cell Culture Supernates
  48. High serum resistin associates with intrahepatic inflammation and necrosis: an index of disease severity for patients with chronic HBV infection
    Authors: Z Meng, Y Zhang, Z Wei, P Liu, J Kang, Y Zhang, D Ma, C Ke, Y Chen, J Luo, Z Gong
    BMC Gastroenterol, 2017-01-07;17(1):6.
    Species: Human
    Sample Types: Serum
  49. Lacrimal gland-derived IL-22 regulates IL-17-mediated ocular mucosal inflammation
    Authors: YW Ji, SK Mittal, HS Hwang, EJ Chang, JH Lee, Y Seo, A Yeo, H Noh, HS Lee, SK Chauhan, HK Lee
    Mucosal Immunol, 2017-01-04;0(0):.
    Species: Human, Mouse
    Sample Types: Cell Culture Supernates, Tissue Homogenates
  50. Increased interleukin (IL)-17 serum levels in patients with hidradenitis suppurativa: Implications for treatment with anti-IL-17 agents
    Authors: ?ukasz Matusiak
    J. Am. Acad. Dermatol, 2016-12-29;0(0):.
    Species: Human
    Sample Types: Serum
  51. Downregulation of proinflammatory cytokines in HTLV-1-infected T cells by Resveratrol
    J Exp Clin Cancer Res, 2016-07-22;35(1):118.
    Species: Human
    Sample Types: Cell Culture Supernates
  52. Expression of human gene coding ROR?T receptor depends on the Sp2 transcription factor
    Authors: Marcin Ratajewski
    J Leukoc Biol, 2016-06-02;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  53. CCL20-CCR6 Cytokine Network Facilitate Treg Activity in Advanced Grades and Metastatic Variants of Hepatocellular Carcinoma.
    Authors: Li W, Liu H
    Scand J Immunol, 2016-01-01;83(1):33-7.
    Species: Human
    Sample Types: Tissue Homogenates
  54. Exogenous IFN-beta regulates the RANKL-c-Fos-IFN-beta signaling pathway in the collagen antibody-induced arthritis model.
    Authors: Zhao R, Chen N, Zhou X, Miao P, Hu C, Qian L, Yu Q, Zhang J, Nie H, Chen X, Li P, Xu R, Xiao L, Zhang X, Liu J, Zhang D
    J Transl Med, 2014-12-10;12(1):330.
    Species: Human
    Sample Types: Serum
  55. The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia.
    Authors: Chou C, Lin F, Tsai H, Chang S
    BMC Pulm Med, 2014-11-19;14(0):182.
    Species: Human
    Sample Types: BALF
  56. Live attenuated B. pertussis BPZE1 rescues the immune functions of Respiratory Syncytial virus infected human dendritic cells by promoting Th1/Th17 responses.
    Authors: Schiavoni I, Fedele G, Quattrini A, Bianco M, Schnoeller C, Openshaw P, Locht C, Ausiello C
    PLoS ONE, 2014-06-26;9(6):e100166.
    Species: Human
    Sample Types: Cell Culture Supernates
  57. Overexpression of IL-17RC associated with ocular sarcoidosis.
    Authors: Wu W, Jin M, Wang Y, Liu B, Shen D, Chen P, Hannes S, Li Z, Hirani S, Jawad S, Sen H, Chan C, Nussenblatt R, Wei L
    J Transl Med, 2014-05-31;12(0):152.
    Species: Human
    Sample Types: Serum
  58. Absence of a role for interleukin-13 in inflammatory bowel disease.
    Authors: Biancheri P, Di Sabatino A, Ammoscato F, Facciotti F, Caprioli F, Curciarello R, Hoque S, Ghanbari A, Joe-Njoku I, Giuffrida P, Rovedatti L, Geginat J, Corazza G, MacDonald T
    Eur J Immunol, 2014-02-01;44(2):370-85.
    Species: Human
    Sample Types: Cell Culture Supernates
  59. The pro-inflammatory potential of T cells in juvenile-onset systemic lupus erythematosus.
    Authors: Ballantine L, Ong J, Midgley A, Watson L, Flanagan B, Beresford M
    Pediatr Rheumatol Online J, 2014-01-16;12(0):4.
    Species: Human
    Sample Types: Plasma
  60. Long-lasting effects of BCG vaccination on both heterologous Th1/Th17 responses and innate trained immunity.
    Authors: Kleinnijenhuis J, Quintin J, Preijers F, Benn C, Joosten L, Jacobs C, van Loenhout J, Xavier R, Aaby P, van der Meer J, van Crevel R, Netea M
    J Innate Immun, 2013-10-30;6(2):152-8.
    Species: Human
    Sample Types: Cell Culture Supernates
  61. Multiple sclerosis lymphocytes upregulate A2A adenosine receptors that are antiinflammatory when stimulated.
    Authors: Vincenzi F, Corciulo C, Targa M, Merighi S, Gessi S, Casetta I, Gentile M, Granieri E, Borea P, Varani K
    Eur J Immunol, 2013-06-03;43(8):2206-16.
    Species: Human
    Sample Types: Cell Culture Supernates
  62. The systemic cytokine environment is permanently altered in multiple myeloma.
    Authors: Zheng M, Zhang Z, Bemis K, Belch A, Pilarski L, Shively J, Kirshner J
    PLoS ONE, 2013-03-27;8(3):e58504.
    Species: Human
    Sample Types: Plasma
  63. Elevated serum levels of interleukin-17A in children with autism.
    Authors: Al-Ayadhi LY, Mostafa GA
    J Neuroinflammation, 2012-07-02;9(1):158.
    Species: Human
    Sample Types: Serum
  64. IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma.
    Authors: Miyagaki T, Sugaya M, Suga H, Kamata M, Ohmatsu H, Fujita H, Asano Y, Tada Y, Kadono T, Sato S
    Clin. Cancer Res., 2011-11-02;17(24):7529-38.
    Species: Human
    Sample Types: Serum
  65. Identification of human NK17/NK1 cells.
    Authors: Pandya AD, Al-Jaderi Z, Hoglund RA, Holmoy T, Harbo HF, Norgauer J, Maghazachi AA
    PLoS ONE, 2011-10-21;6(10):e26780.
    Species: Human
    Sample Types: Cell Culture Supernates
  66. Cytokine Response Patterns in Severe Pandemic 2009 H1N1 and Seasonal Influenza among Hospitalized Adults.
    Authors: Lee N, Wong CK, Chan PK, Chan MC, Wong RY, Lun SW, Ngai KL, Lui GC, Wong BC, Lee SK, Choi KW, Hui DS
    PLoS ONE, 2011-10-13;6(10):e26050.
    Species: Human
    Sample Types: Plasma
  67. Complement component C5a Promotes Expression of IL-22 and IL-17 from Human T cells and its Implication in Age-related Macular Degeneration.
    Authors: Liu B, Wei L, Meyerle C, Tuo J, Sen HN, Li Z, Chakrabarty S, Agron E, Chan CC, Klein ML, Chew E, Ferris F, Nussenblatt RB
    J Transl Med, 2011-07-15;9(0):111.
    Species: Human
    Sample Types: Serum
  68. Kinetics of circulating Th17 cytokines and adipokines in psoriasis patients.
    Authors: Nakajima H, Nakajima K, Tarutani M, Morishige R, Sano S
    Arch. Dermatol. Res., 2011-06-17;303(6):451-5.
    Species: Human
    Sample Types: Serum
  69. Preclinical Evaluation of Local JAK1 and JAK2 Inhibition in Cutaneous Inflammation.
    Authors: Fridman JS, Scherle PA, Collins R, Burn T, Neilan CL, Hertel D, Contel N, Haley P, Thomas B, Shi J, Collier P, Rodgers JD, Shepard S, Metcalf B, Hollis G, Newton RC, Yeleswaram S, Friedman SM, Vaddi K
    J. Invest. Dermatol., 2011-06-16;131(9):1838-44.
    Species: Human
    Sample Types: Cell Culture Supernates
  70. Subnormal cytokine profile in the tear fluid of keratoconus patients.
    Authors: Jun AS, Cope L, Speck C, Feng X, Lee S, Meng H, Hamad A, Chakravarti S
    PLoS ONE, 2011-01-27;6(1):e16437.
    Species: Human
    Sample Types: Tears
  71. Presence of IL-5 protein and IgE antibodies to staphylococcal enterotoxins in nasal polyps is associated with comorbid asthma.
    Authors: Bachert C, Zhang N, Holtappels G, De Lobel L, Van Cauwenberge P, Liu S, Lin P, Bousquet J, Van Steen K
    J. Allergy Clin. Immunol., 2010-11-01;126(5):962.
    Species: Human
    Sample Types: Tissue Homogenates
  72. B7-h3 augments the inflammatory response and is associated with human sepsis.
    Authors: Zhang G, Wang J, Kelly J
    J. Immunol., 2010-08-09;185(6):3677-84.
    Species: Human
    Sample Types: Plasma
  73. Expression of the T helper 17-associated cytokines IL-17A and IL-17F in asthma and COPD.
    Authors: Doe C, Bafadhel M, Siddiqui S, Desai D, Mistry V, Rugman P, McCormick M, Woods J, May R, Sleeman MA, Anderson IK, Brightling CE
    Chest, 2010-06-10;138(5):1140-7.
    Species: Human
    Sample Types: Sputum
  74. An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach.
    Authors: Bakker GC, van Erk MJ, Pellis L, Wopereis S, Rubingh CM, Cnubben NH, Kooistra T, van Ommen B, Hendriks HF
    Am. J. Clin. Nutr., 2010-02-24;91(4):1044-59.
    Species: Human
    Sample Types: Plasma
  75. The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis.
    Authors: Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Docke WD, Asadullah K, Volk HD, Sterry W, Sabat R
    Eur. J. Immunol., 2009-12-01;39(12):3570-81.
    Species: Human
    Sample Types: Serum
  76. Opposing roles of IL-17A and IL-25 in the regulation of TSLP production in human nasal epithelial cells.
    Authors: Xu G, Zhang L, Wang DY, Xu R, Liu Z, Han DM, Wang XD, Zuo KJ, Li HB
    Allergy, 2009-11-25;65(5):581-9.
    Species: Human
    Sample Types: Nasal Lavage Fluid
  77. Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria.
    Authors: Sadeghi M, Daniel V, Schnitzler P, Lahdou I, Naujokat C, Zeier M, Opelz G
    Transplantation, 2009-11-15;88(9):1109-16.
    Species: Human
    Sample Types: Urine
  78. Regulating human Th17 cells via differential expression of IL-1 receptor.
    Authors: Lee WW, Kang SW, Choi J
    Blood, 2009-11-12;115(3):530-40.
    Species: Human
    Sample Types: Cell Culture Supernates
  79. Intervention of an inflammation amplifier, triggering receptor expressed on myeloid cells 1, for treatment of autoimmune arthritis.
    Authors: Murakami Y, Akahoshi T, Aoki N, Toyomoto M, Miyasaka N, Kohsaka H
    Arthritis Rheum., 2009-06-01;60(6):1615-23.
    Species: Human
    Sample Types: Serum
  80. IL-17 induces monocyte migration in rheumatoid arthritis.
    Authors: Shahrara S, Pickens SR, Dorfleutner A, Pope RM
    J. Immunol., 2009-03-15;182(6):3884-91.
    Species: Human
    Sample Types: Synovial Fluid
  81. Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
    Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
    J. Exp. Med., 2009-03-09;206(3):535-48.
    Species: Human
    Sample Types: Cell Culture Supernates
  82. Serum interleukin-17 levels are related to clinical severity in allergic rhinitis.
    Authors: Ciprandi G, De Amici M, Murdaca G, Fenoglio D, Ricciardolo F, Marseglia G, Tosca M
    Allergy, 2009-02-17;64(9):1375-8.
    Species: Human
    Sample Types: Serum
  83. Interleukin 17: an unlikely marker of acute coronary syndrome?
    Authors: Patel KD, Murphy RT, White M, Gasparro D, Kelleher DP, Ryan T, McManus R, Ryan AW
    Atherosclerosis, 2008-12-03;205(1):33-4.
    Species: Human
    Sample Types: Serum
  84. IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response.
    Authors: Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, Ring J, Traidl-Hoffmann C, Albanesi C, Cavani A
    J. Allergy Clin. Immunol., 2008-12-03;123(1):59-66.e4.
    Species: Human
    Sample Types: Cell Culture Supernates
  85. Serum levels of MMP-3 and cathepsin K in patients with ankylosing spondylitis: effect of TNFalpha antagonist therapy.
    Authors: Wendling D, Cedoz JP, Racadot E
    Joint Bone Spine, 2008-10-01;75(5):559-62.
    Species: Human
    Sample Types: Serum
  86. Increased numbers of circulating polyfunctional Th17 memory cells in patients with seronegative spondylarthritides.
    Authors: Jandus C, Bioley G, Rivals JP, Dudler J, Speiser D, Romero P
    Arthritis Rheum., 2008-08-01;58(8):2307-17.
    Species: Human
    Sample Types: Cell Culture Supernates
  87. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes.
    Authors: Pene J, Chevalier S, Preisser L, Venereau E, Guilleux MH, Ghannam S, Moles JP, Danger Y, Ravon E, Lesaux S, Yssel H, Gascan H
    J. Immunol., 2008-06-01;180(0):7423.
    Species: Human
    Sample Types: Cell Culture Supernates
  88. Memory Th-17 cells specific for C. albicans are persistent in human peripheral blood.
    Authors: Zhou M, Yang B, Ma R, Wu C
    Immunol. Lett., 2008-04-09;118(1):72-81.
    Species: Human
    Sample Types: Cell Culture Supernates
  89. Linking genetic susceptibility to Crohn's disease with Th17 cell function: IL-22 serum levels are increased in Crohn's disease and correlate with disease activity and IL23R genotype status.
    Authors: Schmechel S, Konrad A, Diegelmann J, Glas J, Wetzke M, Paschos E, Lohse P, Goke B, Brand S
    Inflamm. Bowel Dis., 2008-02-01;14(2):204-12.
    Species: Human
    Sample Types: Serum
  90. IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response.
    Authors: Rao DA, Tracey KJ, Pober JS
    J. Immunol., 2007-11-15;179(10):6536-46.
    Species: Human
    Sample Types: Cell Culture Supernates
  91. IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease.
    Authors: Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R
    J. Immunol., 2007-05-01;178(9):5973-81.
    Species: Human
    Sample Types: Cell Culture Supernates
  92. IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production.
    Authors: Vaknin-Dembinsky A, Balashov K, Weiner HL
    J. Immunol., 2006-06-15;176(12):7768-74.
    Species: Human
    Sample Types: Cell Culture Supernates
  93. Levels of interleukin-17 in gingival crevicular fluid and in supernatants of cellular cultures of gingival tissue from patients with chronic periodontitis.
    Authors: Vernal R, Dutzan N, Chaparro A, Puente J, Antonieta Valenzuela M, Gamonal J
    J. Clin. Periodontol., 2005-04-01;32(4):383-9.
    Species: Human
    Sample Types:
  94. Cytokine profile in Behcet's disease patients. Relationship with disease activity.
    Authors: Hamzaoui K, Hamzaoui A, Guemira F, Bessioud M, Hamza M, Ayed K
    Scand. J. Rheumatol., 2002-01-01;31(4):205-10.
    Species: Human
    Sample Types: Serum
  95. Stimulation of 92-kd gelatinase (matrix metalloproteinase 9) production by interleukin-17 in human monocyte/macrophages: a possible role in rheumatoid arthritis.
    Authors: Jovanovic DV, Martel-Pelletier J, Di Battista JA, Mineau F, Jolicoeur FC, Benderdour M, Pelletier JP
    Arthritis Rheum., 2000-05-01;43(5):1134-44.
    Species: Human
    Sample Types: Synovial Fluid

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Human IL-17 Quantikine ELISA Kit
By Anonymous on 10/26/2015
Sample Tested: T cells Species: Human

Standard curve is shown.
Buffer: kit dilution buffer
Dilution: 1/100

Human IL-17 Quantikine ELISA Kit D1700