Human IL-24 Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-24
Interleukin 24 (IL-24), also known as mda-7 (melanoma differentiation associated gene-7), is a member of the IL-10 family of helical cytokines. The IL-24 gene encodes a precursor protein of 207 amino acids (aa) that contains a 48 aa signal sequence and an 18 kDa, 158 aa mature segment. There are three potential N-linked glycosylation sites, at least one of which is used. When secreted, IL-24 is a 35-40 kDa phosphorylated glycoprotein that apparently can exist as either a monomer or dimer. It is suggested that glycosylation is essential for activity. Mature human IL-24 shares 69% aa sequence identity with mouse and rat IL-24. Human IL-24 is also active in rodent systems. Cells known to express IL-24 include B cells, CD4+ T cells, NK cells, lymph node dendritic cells, monocytes, melanocytes, and melanoma cells. Functionally, IL-24 has diverse activities. At low concentrations on monocytes, it induces type I proinflammatory cytokines such as IFN-gamma, IL-1 beta, IL‑12, and TNF-alpha. At high concentrations, it is a strong inducer of apoptosis in tumor cells, but not normal cells. IL-24 also has anti-angiogenic properties. It directly binds IL-24 receptors on endothelial cells, activating STAT3 and blocking their differentiation. IL-24 binds and signals through two heterodimeric receptor complexes. One complex is the combination of IL-20 R alpha and IL-20 R beta, which is shared with IL-19 and IL-20. The second complex is a combination of IL-22 R and IL-20 R beta, which is shared with IL-20.
- Jiang, H. et al. (1995) Oncogene 11:2477.
- Jiang, H. et al. (1996) Proc. Natl. Acad. Sci. USA 93:9160.
- Wang, M. et al. (2002) J. Biol Chem. 227:7341.
- Chada, S. et al. (2004) Int. Immunopharmacol. 4:649.
- Pestka, S. et al. (2004) Annu. Rev. Immunol. 22:929.
- Chen, J. et al. (2003) Molec. Ther. 8:220.
Product Datasheets
Citations for Human IL-24 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 7
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Secreted recombinant human IL-24 protein inhibits the proliferation of esophageal squamous cell carcinoma Eca-109 cells in vitro and in vivo
Authors: QUNFENG MA, BANGMING JIN, YAO ZHANG, YINAN SHI, CHI ZHANG, DAN LUO et al.
Oncology Reports
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Oncolytic adenovirus-mediated mda-7/IL-24 expression suppresses osteosarcoma growth and enhances sensitivity to doxorubicin
Authors: ZONGMING LIU, LIBO XU, HONGPING YUAN, YANG ZHANG, XIAONA ZHANG, DONGXU ZHAO
Molecular Medicine Reports
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Prokaryotically and eukaryotically expressed interleukin-24 induces breast cancer growth suppression via activation of apoptosis and inhibition of tumor angiogenesis
Authors: SHAOHUA WEI, HUA CAO, XIAOYAN ZHOU, HAORONG WU, JICHENG YANG
Molecular Medicine Reports
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A novel human interleukin-24 peptide created by computer-guided design contributes to suppression of proliferation in esophageal squamous cell carcinoma Eca-109 cells
Authors: QUNFENG MA, XUEFENG DENG, BANGMING JIN, YAO ZHANG, DAN LUO, HEYU SONG et al.
Oncology Reports
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Enhanced tumor suppression by an ING4/IL-24 bicistronic adenovirus-mediated gene cotransfer in human non-small cell lung cancer cells.
Authors: Zhu Y, Lv H, Xie Y
Cancer Gene Ther., 2011-06-10;18(9):627-36.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells.
Authors: Maarof G, Bouchet-Delbos L, Gary-Gouy H, Durand-Gasselin I, Krzysiek R, Dalloul A
Blood, 2009-11-24;115(9):1718-26.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Enhanced antitumor activity by a selective conditionally replicating adenovirus combining with MDA-7/interleukin-24 for B-lymphoblastic leukemia via induction of apoptosis.
Authors: Qian W, Liu J, Tong Y, Yan S, Yang C, Yang M, Liu X
Leukemia, 2007-11-29;22(2):361-9.
Species: Human
Sample Types: Cell Lysates, Whole Cells, Whole Tissue
Applications: ICC, IHC-P, Western Blot
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