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Human IL-7 Biotinylated Fluorokine Flow Cytometry Kit

Catalog #: NF700
5 Citations Datasheet / COA / SDS

Discontinued Product

NF700 has been discontinued.
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Citations (5)
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Summary Product Datasheets Background

Human IL-7 Biotinylated Fluorokine Flow Cytometry Kit Summary

Specifications

Source
N/A
Shipping Conditions
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Species
Human

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COA
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Background: IL-7

IL-7 (Interleukin-7) is a cytokine that plays important roles in lymphocyte differentiation, proliferation, and survival. IL-7 is produced by stromal epithelial cells of the thymus, bone marrow, and intestines. It signals through a receptor complex composed of IL-7 R alpha/CD127 and the Common gamma Chain. gamma c is also a subunit of the receptors for IL-2, -4, -9, -15, and -21. IL-7 contributes to the maintenance of all naïve and memory T cells. It is required for optimal T cell-dendritic cell interaction. In mouse, IL-7 activation of IL-7 R alpha is critical for both T cell and B cell lineage development, while in humans, it is required for T cell but not for B cell development.

Long Name
Interleukin 7
Entrez Gene IDs
3574 (Human); 16196 (Mouse); 25647 (Rat)
Alternate Names
IL7; IL-7; IL-7interleukin-7; interleukin 7; Lymphopoietin-1; PBGF

Citations for Human IL-7 Biotinylated Fluorokine Flow Cytometry Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7R alpha surface expression.
    Authors: McLeod IX, Zhou X, Li QJ, Wang F, He YW
    J. Immunol., 2011-10-21;187(10):5051-61.  2011-10-21
  2. Dual mechanism of impairment of interleukin-7 (IL-7) responses in human immunodeficiency virus infection: decreased IL-7 binding and abnormal activation of the JAK/STAT5 pathway.
    Authors: Juffroy O, Bugault F, Lambotte O, Landires I, Viard JP, Niel L, Fontanet A, Delfraissy JF, Theze J, Chakrabarti LA
    J. Virol., 2010-01-01;84(1):96-108.  2010-01-01
  3. Control of pre-BCR signaling by Pax5-dependent activation of the BLNK gene.
    Authors: Schebesta M, Pfeffer PL, Busslinger M
    Immunity, 2002-10-01;17(4):473-85.  2002-10-01
  4. Functional interleukin-7 receptors (IL-7Rs) are expressed by marrow stromal cells: binding of IL-7 increases levels of IL-6 mRNA and secreted protein.
    Authors: Iwata M, Graf L, Awaya N, Torok-Storb B
    Blood, 2002-08-15;100(4):1318-25.  2002-08-15
  5. Chronic & infrequent opioid exposure suppresses IL-2R expression on rhesus monkey peripheral blood mononuclear cells following stimulation with pokeweed mitogen.
    Authors: Carr DJ, ºùN•iÓ)f½, Carpenter GW, i%Êv-Ž¦, Garza HH, France CP, Prakash OM
    1995-03-01;81(1):137-48.  1995-03-01

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