Human Integrin beta 6 APC-conjugated Antibody

Catalog #: FAB4155A
3 Citations Datasheet / COA / SDS

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FAB4155A

Detection of Integrin beta 6 in HT‑29 Human Cell Line by Flow Cytometry.

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Citations (3)

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Human Integrin beta 6 APC-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Integrin beta 6 in direct ELISAs.

Source

Monoclonal Mouse IgG_2B Clone # 437211

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Chinese hamster ovary cell line CHO-derived recombinant human Integrin alpha V beta 6
Phe31-Val992 (Integrin alpha V) and Gly22-Asn707 (Integrin beta 6)
Accession # P18564 (Integrin beta 6)

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Label

Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

10 µL/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of Integrin beta 6 in HT‑29 Human Cell Line by Flow Cytometry. HT-29 human colon adenocarcinoma cell line was stained with Mouse Anti-Human Integrin beta 6 APC-conjugated Monoclonal Antibody (Catalog # FAB4155A, filled histogram) or isotype control antibody (Catalog # IC0041A, open histogram). View our protocol for Staining Membrane-associated Proteins.

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Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store the unopened product at 2 - 8° C. Do not use past expiration date. Protect from light.

Background: Integrin beta 6

Integrin beta 6 (ITG beta 6) is a 95 kDa member of the Integrin beta family. It forms noncovalent heterodimers with Integrin alpha V and appears on epithelia following injury or inflammation. It activates TGF-beta and assists keratinocyte migration. Human Integrin beta 6 is a type I transmembrane glycoprotein that is 767 amino acids (aa) in length. It contains a 688 aa extracellular domain (ECD) (aa 22-709) that incorporates a 241 aa VWF-A domain. Over aa 22-707, human integrin beta 6 ECD shares 90% and 93% aa sequence identity with mouse and pig integrin beta 6 ECD, respectively.

Entrez Gene IDs

3694 (Human); 16420 (Mouse); 311061 (Rat); 102122296 (Cynomolgus Monkey)

Alternate Names

Integrin beta 6; integrin beta-6; integrin, beta 6; ITGB6

Product Datasheets

Product Datasheet

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Related Research Areas

Citations for Human Integrin beta 6 APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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Engineering a Dual Specificity ?? T-Cell Receptor for Cancer Immunotherapy
Authors: Davies, DM;Pugliese, G;Parente Pereira, AC;Whilding, LM;Larcombe-Young, D;Maher, J;
Biology
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Halting the Spread of Herpes Simplex Virus-1: The Discovery of an Effective Dual alpha v beta 6/ alpha v beta 8 Integrin Ligand
Authors: Stefano Tomassi, Vincenzo Maria D’Amore, Francesco Saverio Di Leva, Andrea Vannini, Giacomo Quilici, Michael Weinmüller et al.
Journal of Medicinal Chemistry
Multifunctional alpha v beta 6 Integrin-Specific Peptide–Pt(IV) Conjugates for Cancer Cell Targeting
Authors: Anne C. Conibear, Sonja Hager, Josef Mayr, Matthias H. M. Klose, Bernhard K. Keppler, Christian R. Kowol et al.
Bioconjugate Chemistry