Human Lysyl Oxidase Homolog 3 (NP_115992) VersaClone cDNA

Catalog #: RDC2944 Datasheet / COA / SDS

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RDC2944

Human Lysyl Oxidase Homolog 3 (NP_115992) VersaClone cDNA

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Human Lysyl Oxidase Homolog 3 (NP_115992) VersaClone cDNA Summary

Specifications

Source

N/A

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species

Human

Product Datasheets

Product Datasheet

COA

SDS

Background: Lysyl Oxidase Homolog 3/LOXL3

Lysyl oxidase-like protein 3 (LOXL3) is a secreted copper amine oxidase. The N-terminal region of LOXL3 contains four scavenger receptor cysteine-rich (SRCR) domains. The C-terminal region consists of a catalytic domain similar to other lysyl oxidases and a cytokine receptor-like domain. The catalytic domain contains conserved residues required for copper binding and formation of a lysyl tyrosylquinone cofactor. LOXL3 is expressed primarily in epidermis, kidney, aorta, and chondrocytes. The enzyme is expressed at low levels in most other tissues. Like lysyl oxidase, LOXL3 oxidizes the lysine e-amino groups of a number of collagen substrates, and is also active against other primary amines. However, LOXL3 does not require proteolytic processing to be activated.

Entrez Gene IDs

84695 (Human); 16950 (Mouse)

Alternate Names

EC 1.4.3; EC 1.4.3.-; EC 1.4.3.13; LOL3; LOXL; LOXL3; Lysyl Oxidase Homolog 3; lysyl oxidase-like 3; Lysyl oxidase-like protein 3