Home / STAT3 / Human/Mouse Phospho-STAT3 (Y705) DuoSet IC ELISA

Human/Mouse Phospho-STAT3 (Y705) DuoSet IC ELISA

Catalog #: DYC4607-2
9 Citations Datasheet / COA / SDS

Discontinued Product

DYC4607-2 has been discontinued.
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Citations (9)
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Summary Product Datasheets Preparation and Storage Background

Human/Mouse Phospho-STAT3 (Y705) DuoSet IC ELISA Summary

Assay Range
781.0 - 50,000 pg/mL
Specificity
Please see the product datasheet

* Provided that the recommended microplates, buffers, diluents, substrates and solutions are used, and the assay is run as summarized in the Assay Procedure provided.

Product Datasheets

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Product Datasheet
COA
SDS

Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: STAT3

The STAT family of transcription factors, first described as key mediators of interferon signal transduction, are now recognized as signaling factors downstream of many cytokines, growth factors, and hormones. At least seven STATs exist: STAT1, 2, 3, 4, 5a, 5b, and 6. They are responsible for an array of cellular activities including regulating growth, survival, differentiation, motility, and the immune response. They are characterized structurally by the presence of the Src homology 2 (SH2) domain, and a C-terminal tyrosine phosphorylation site. Upon ligand binding, they are recruited to the activated receptor, via their SH2 domains, to receptor-associated tyrosine kinases of the Janus kinase family (JAK). Once phosphorylated by JAK, STATS are free to hetero- or homo-dimerize, and translocate to the nucleus where they bind DNA to regulate gene transcription.

Long Name:
Signal Transducer and Activator of Transcription 3
Entrez Gene IDs:
6774 (Human); 20848 (Mouse); 25125 (Rat)
Alternate Names:
Acute-phase response factor; APRFMGC16063; DNA-binding protein APRF; FLJ20882; HIES; signal transducer and activator of transcription 3 (acute-phase responsefactor); signal transducer and activator of transcription 3; STAT3

Citations for Human/Mouse Phospho-STAT3 (Y705) DuoSet IC ELISA

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

9 Citations: Showing 1 - 9
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  1. ATP6V0D1 promotes alkaliptosis by blocking STAT3-mediated lysosomal pH homeostasis
    Authors: F Chen, S Zhu, R Kang, D Tang, J Liu
    Cell Reports, 2022-12-29;42(1):111911.
    Species: Human
    Sample Types: Cell Culture Supernates
  2. Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model
    Authors: T Fukasawa, A Yoshizaki, S Ebata, A Yoshizaki-, Y Asano, A Enomoto, K Miyagawa, Y Kazoe, K Mawatari, T Kitamori, S Sato
    Elife, 2021-12-02;10(0):.
    Species: Human
    Sample Types: Cell Lysates
  3. miR-21-3p/IL-22 Axes Are Major Drivers of Psoriasis Pathogenesis by Modulating Keratinocytes Proliferation-Survival Balance and Inflammatory Response
    Authors: F Abdallah, E Henriet, A Suet, A Arar, R Clemençon, JM Malinge, G Lecellier, P Baril, C Pichon
    Cells, 2021-09-26;10(10):.
    Species: Human
    Sample Types: Cell Lysates
  4. Microfluidic Single-Cell Proteomics Assay Chip: Lung Cancer Cell Line Case Study
    Authors: Y Jung, M Son, YR Nam, J Choi, JR Heath, S Yang
    Micromachines, 2021-09-23;12(10):.
    Species: Human
    Sample Types: Cell Lysates
  5. Identification of a Novel Bone Marrow Cell-Derived Accelerator of Fibrotic Liver Regeneration Through Mobilization of Hepatic Progenitor Cells in Mice
    Authors: T Yanagawa, H Sumiyoshi, K Higashi, S Nakao, R Higashiyam, H Fukumitsu, K Minakawa, Y Chiba, Y Suzuki, K Sumida, K Saito, A Kamiya, Y Inagaki
    Stem Cells, 2018-10-31;37(1):89-101.
    Species: Mouse
    Sample Types: Cell Lysates
  6. Upregulation of SOCS3 in lung CD4+ T cells in a mouse model of chronic PA lung infection and suppression of Th17?mediated neutrophil recruitment in exogenous SOCS3 transfer in vitro
    Authors: FM Ding, RM Liao, YQ Chen, GG Xie, PY Zhang, P Shao, M Zhang
    Mol Med Rep, 2017-05-25;0(0):.
    Species: Mouse
    Sample Types: Tissue Homogenates
  7. Metformin inhibits the inflammatory response associated with cellular transformation and cancer stem cell growth.
    Proc Natl Acad Sci U S A, 2012-12-31;110(3):972-7.
    Species: Human
    Sample Types: Cell Lysates
  8. Microarray-based kinetic colorimetric detection for quantitative multiplex protein phosphorylation analysis.
    Authors: Holenya P, Kitanovic I, Heigwer F, Wolfl S
    Proteomics, 2011-04-18;11(10):2129-33.
    Species: Human
    Sample Types: Recombinant Protein
  9. IFN-alpha blocks IL-17 production by peripheral blood mononuclear cells in Behcet's disease.
    Authors: Liu X, Yang P, Wang C, Li F, Kijlstra A
    Rheumatology (Oxford), 2010-11-08;50(2):293-8.
    Species: Human
    Sample Types: Cell Lysates

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