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Human/Mouse/Rat Cytochrome c MAb (Cl 4CytC-21)

Catalog #: 6370-MC-100
3 Citations Datasheet / COA / SDS

Discontinued Product

6370-MC-100 has been discontinued.
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Citations (3)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse/Rat Cytochrome c MAb (Cl 4CytC-21) Summary

Species Reactivity
Human, Mouse, Rat
Source
Monoclonal Mouse IgG1 Clone # 4CytC-21
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Background: Cytochrome c

Cytochrome c is a small, highly conserved, heme-containing protein involved in mitochondrial electron transport. Cytochrome c is released from the mitochondria in response to pro-apoptotic stimuli and serves as a cofactor in initiating the activation of the APAF-1/Caspase-9 complex. The effect of specific proteins and/or small molecules on the initiation of the intrinsic apoptotic pathway can be evaluated in an in vitro system of isolated mitochondria by monitoring the release of cytochrome c.

Entrez Gene IDs
54205 (Human)
Alternate Names
CYCHCS; CYCS; Cytochrome c; cytochrome c, somatic; THC4

Product Datasheets

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COA

Citations for Human/Mouse/Rat Cytochrome c MAb (Cl 4CytC-21)

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Ischemia and reperfusion injury to mitochondria and cardiac function in donation after circulatory death hearts- an experimental study
    Authors: O Akande, Q Chen, S Toldo, EJ Lesnefsky, M Quader
    PLoS ONE, 2020-12-28;15(12):e0243504.
    Species: Rat
    Sample Types: Cell Lysates
    Applications: Western Blot
  2. Cisplatin preferentially binds mitochondrial DNA and voltage-dependent anion channel protein in the mitochondrial membrane of head and neck squamous cell carcinoma: possible role in apoptosis.
    Authors: Yang Z, Schumaker LM, Egorin MJ, Zuhowski EG, Guo Z, Cullen KJ
    Clin. Cancer Res., 2006-10-01;12(19):5817-25.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  3. Mitochondrial dysfunction as an early event in the process of apoptosis induced by woodfordin I in human leukemia K562 cells.
    Authors: Liu MJ, Wang Z, Li HX, Wu RC, Liu YZ, Wu QY
    Toxicol. Appl. Pharmacol., 2004-01-15;194(2):141-55.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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