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Human/Mouse/Rat GDF-11/GDF-8 Antibody

Catalog #: MAB788
12 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB788-SP
MAB788-500
MAB788-100
Product Details
Citations (12)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse/Rat GDF-11/GDF-8 Antibody Summary

Species Reactivity
Human, Mouse, Rat
Specificity
Detects human, mouse, and rat GDF-8 in direct ELISAs and Western blots. In Western blots, this antibody shows approximately 30% cross-reactivity with recombinant human/mouse/rat GDF-11. In direct ELISAs, this antibody shows less than 1% cross-reactivity with recombinant mouse (rm) GDF-1, rmGDF-3, rmGDF-5, rmGDF-6, and rmGDF-9.
Source
Monoclonal Rat IgG2B Clone # 84214
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse GDF-8
Asn25-Ser376
Accession # O08689
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human/Mouse/Rat GDF‑8/Myostatin (Catalog # 788-G8)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: GDF-11/GDF-8

GDF-8, also known as Myostatin, belongs to the TGF-beta superfamily. It is synthesized as an inactive proprotein with the N-terminal pro-region and the C-terminal mature bioactive region. The GDF-8 proregion is capable of associating with active GDF-8 with high affinity and is a potent GDF-8 antagonist.

Long Name
Growth Differentiation Factor 11/8
Entrez Gene IDs
10220 (Human)
Alternate Names
BMP11; BMP-11; bone morphogenetic protein 11; GDF-11; GDF-11/GDF-8; growth/differentiation factor 11; VHO

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Citations for Human/Mouse/Rat GDF-11/GDF-8 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

12 Citations: Showing 1 - 10
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  1. The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy
    Authors: SA Samant, A Kanwal, VB Pillai, R Bao, MP Gupta
    Sci Rep, 2017-09-19;7(1):11877.
  2. Myostatin inhibitory region of fish (Paralichthys olivaceus) myostatin-1 propeptide
    Authors: Sang Beum Lee, Jeong Hwan Kim, Deuk-Hee Jin, Hyung-Joo Jin, Yong Soo Kim
    Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology
  3. Myostatin-1 Inhibits Cell Proliferation by Inhibiting the mTOR Signal Pathway and MRFs, and Activating the Ubiquitin-Proteasomal System in Skeletal Muscle Cells of Japanese Flounder Paralichthys olivaceus
    Authors: J Liu, M Pan, D Huang, Y Guo, M Yang, W Zhang, K Mai
    Cells, 2020-10-29;9(11):.
    Species: Paralichthys olivaceus (Japanese Flounder)
    Sample Types: Cell Lysates
    Applications: Western Blot
  4. Prostate tumor-derived GDF11 accelerates androgen deprivation therapy-induced sarcopenia
    Authors: C Pan, N Jaiswal Ag, Y Zulia, S Singh, K Sha, JL Mohler, KH Eng, J Chakkalaka, JJ Krolewski, KL Nastiuk
    JCI Insight, 2020-03-26;0(0):.
    Species: Mouse
    Sample Types: Cell Culture Lysates
    Applications: Western Blot
  5. The Use of Platelet-Rich and Platelet-Poor Plasma to Enhance Differentiation of Skeletal Myoblasts: Implications for the Use of Autologous Blood Products for Muscle Regeneration
    Authors: O Miroshnych, WT Chang, JL Dragoo
    Am J Sports Med, 2016-12-27;45(4):945-953.
    Species: Human
    Sample Types: Protein
    Applications: Western Blot
  6. Differential muscle hypertrophy is associated with satellite cell numbers and Akt pathway activation following activin type IIB receptor inhibition in Mtm1 p.R69C mice.
    Authors: Lawlor M, Viola M, Meng H, Edelstein R, Liu F, Yan K, Luna E, Lerch-Gaggl A, Hoffmann R, Pierson C, Buj-Bello A, Lachey J, Pearsall S, Yang L, Hillard C, Beggs A
    Am J Pathol, 2014-04-13;184(6):1831-42.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  7. Inhibition of activin receptor type IIB increases strength and lifespan in myotubularin-deficient mice.
    Authors: Lawlor MW, Read BP, Edelstein R, Yang N, Pierson CR, Stein MJ, Wermer-Colan A, Buj-Bello A, Lachey JL, Seehra JS, Beggs AH
    Am. J. Pathol., 2011-02-01;178(2):784-93.
    Species: Mouse
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  8. High concentrations of HGF inhibit skeletal muscle satellite cell proliferation in vitro by inducing expression of myostatin: a possible mechanism for reestablishing satellite cell quiescence in vivo.
    Authors: Yamada M, Tatsumi R, Yamanouchi K, Hosoyama T, Shiratsuchi S, Sato A, Mizunoya W, Ikeuchi Y, Furuse M, Allen RE
    Am. J. Physiol., Cell Physiol., 2009-12-09;298(3):C465-76.
    Species: Rat
    Sample Types: Cell Lysates
    Applications: Western Blot
  9. A new model for growth factor activation: type II receptors compete with the prodomain for BMP-7.
    Authors: Sengle G, Ono RN, Lyons KM, Bachinger HP, Sakai LY
    J. Mol. Biol., 2008-07-02;381(4):1025-39.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: ELISA Development
  10. Targeting of bone morphogenetic protein growth factor complexes to fibrillin.
    Authors: Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bachinger HP, Sakai LY
    J. Biol. Chem., 2008-03-13;283(20):13874-88.
    Species: Human
    Sample Types: Recombinant Protein
    Applications: Western Blot
  11. Gene silencing of myostatin in differentiation of chicken embryonic myoblasts by small interfering RNA.
    Authors: Sato F, Kurokawa M, Yamauchi N, Hattori MA
    Am. J. Physiol., Cell Physiol., 2006-04-12;291(3):C538-45.
    Species: Chicken
    Sample Types: Cell Lysates
    Applications: Western Blot
  12. Skeletal muscle‐specific over‐expression of the nuclear sirtuin SIRT6 blocks cancer‐associated cachexia by regulating multiple targets
    Authors: Sadhana A. Samant, Vinodkumar B. Pillai, Mahesh P. Gupta
    JCSM Rapid Communications

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