Human/Mouse Serpin I1 Antibody

Catalog #: MAB3124 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
MAB3124
MAB3124-SP

All Serpin I1 Antibodies

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human/Mouse Serpin I1 Antibody Summary

Species Reactivity

Human, Mouse

Specificity

Detects human and mouse SerpinI1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, 100% cross reactivity with recombinant mouse Serpin I1 is observed and no cross-reactivity with recombinant human Serpin A1, A3, A4, A5, A12, B6, B8, B9, C1, D1, F2, G1, or I2 is observed.

Source

Monoclonal Rat IgG_2A Clone # 437016

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Serpin I1
Ala19-Leu410
Accession # AAH18043

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration

Sample

Western Blot

1 µg/mL

Recombinant Human and Mouse Serpin I1

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Serpin I1

Serpin I1, also known as neuroserpin, is a secreted serine protease inhibitor predominantly expressed in the brain. Serpin I1 defects cause familial encephalopathy with neuroserpin inclusion bodies (FEN1B), an autosomal dominant dementia. The amino acid sequence of human Serpin I1 is 99%, 93%, 88%, 86% and 80% identical to that of chimpanzee, dog, rat, mouse and chicken.

Entrez Gene IDs

5274 (Human); 20713 (Mouse); 116459 (Rat)

Alternate Names

DKFZp781N13156; Neuroserpin; Peptidase inhibitor 12; PI12; PI-12; PI12Serpin I1; serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 1; Serpin I1; serpin peptidase inhibitor, clade I (neuroserpin), member 1