Human Nidogen-2 (NP_031387.3) VersaClone cDNA

Catalog #: RDC3550 Datasheet / COA / SDS

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RDC3550

Human Nidogen-2 (NP_031387.3) VersaClone cDNA

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Human Nidogen-2 (NP_031387.3) VersaClone cDNA Summary

Specifications

Source

N/A

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species

Human

Product Datasheets

Product Datasheet

COA

SDS

Background: Nidogen-2

Nidogen-2 (also called entactin-2) is a 200 kDa, secreted, basement membrane glycoprotein. Nidogens-1 and -2 are expressed in nearly all basement membranes where they interact with laminins, collagen type IV, and proteoglycan family members. Nidogen-2 contains three globular domains (G1-3) separated by a link region and an extended rod-shaped segment. The G1 domain is reported to bind type IV collagen, the G2 domain interacts with perlecan, and C-terminal G3 is associated with laminin binding. There is one EGF-like motif and a short peptide that ligates alpha 3 beta 1 integrins. The rod-shaped segment contains four additional EGF-like motifs and two thyroglobulin type 1 domains that serve as a binding site for alpha V beta 3 integrins.

Entrez Gene IDs

22795 (Human); 18074 (Mouse); 302248 (Rat)

Alternate Names

NID2; NID-2; nidogen 2 (osteonidogen); Nidogen2; Nidogen-2; Osteonidogen