Human OCIL/CLEC2d APC-conjugated Antibody Summary
Ser57-Val191
Accession # Q9UHP7
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of OCIL/CLEC2d in Raji Human Cell Line by Flow Cytometry. Raji human Burkitt's lymphoma cell line was stained with Mouse Anti-Human OCIL/CLEC2d APC-conjugated Monoclonal Antibody (Catalog # FAB3480A, filled histogram) or isotype control antibody (IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of OCIL/CLEC2d in Ramos cells by Flow Cytometry Ramos cells were stained with Mouse Anti-Human OCIL/CLEC2d APC‑conjugated Monoclonal Antibody (Catalog # FAB3480A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: OCIL/CLEC2d
Human OCIL (osteoclast inhibitory lectin; also LLT1 and CLEC-2D) is a member of the NK cell receptor group of the C-type lectin superfamily. It is a type II transmembrane protein 191 amino acids (aa) in length that contains a C-terminal 132 aa extracellular domain (ECD). Within the ECD lies a C-type lectin domain (aa 75‑186). There are at least two alternate splice forms of OCIL. Both exhibit splicing in the ECD. One shows a 40 aa substitution for the C-terminal 37 amino acids. A second shows a 3 aa substitution for the C-terminal 72 amino acids. The ECD of human OCIL is 49% and 50% aa identical to the ECD in mouse and rat OCIL ECD, respectively. The molecule is found on hematopoietic cells, osteoblasts and chondrocytes. It binds sulfated GAGs and NKR-P1B and D receptors, and blocks osteoclast formation.
Product Datasheets
Citations for Human OCIL/CLEC2d APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 4
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Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance
Authors: Dario Gerace, Quan Zhou, Jennifer Hyoje-Ryu Kenty, Adrian Veres, Elad Sintov, Xi Wang et al.
Cell Reports Medicine
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iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity
Authors: D Suzuki, C Flahou, N Yoshikawa, I Stirblyte, Y Hayashi, A Sawaguchi, M Akasaka, S Nakamura, N Higashi, H Xu, T Matsumoto, K Fujio, MG Manz, A Hotta, H Takizawa, K Eto, N Sugimoto
Stem Cell Reports, 2019-12-26;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Molecular signatures associated with tumor-specific immune response in melanoma patients treated with dendritic cell-based immunotherapy
Authors: T García-Sal, A Villablanc, F Matthäus, A Tittarelli, M Baeza, C Pereda, MA Gleisner, FE González, MN López, JD Hoheisel, J Norgauer, PJ Gebicke-Ha, F Salazar-On
Oncotarget, 2018-03-30;9(24):17014-17027.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Expression of Lectin-Like Transcript 1, the Ligand for CD161, in Rheumatoid Arthritis.
Authors: Chalan P, Bijzet J, Huitema M, Kroesen B, Brouwer E, Boots A
PLoS ONE, 2015-07-06;10(7):e0132436.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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