Human Park7/DJ-1 Biotinylated Antibody

Catalog #: BAF3995
2 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
BAF3995

All Park7/DJ-1 Antibodies

Product Details

Citations (2)

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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Park7/DJ-1 Biotinylated Antibody Summary

Species Reactivity

Human

Specificity

Detects human Park7/DJ-1 in Western blots. In this format, approximately 40% cross-reactivity with recombinant mouse Park7 is observed.

Source

Polyclonal Goat IgG

Purification

Antigen Affinity-purified

Immunogen

E. coli-derived recombinant human Park7/DJ-1
Met1-Asp189
Accession # Q99497

Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.

Label

Biotin

Applications

Recommended Concentration

Sample

Western Blot

0.1 µg/mL

Recombinant Human Park7/DJ‑1

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Reconstitution

Reconstitute at 0.2 mg/mL in sterile PBS.

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.

12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Park7/DJ-1

Park7, also known as DJ-1, is a cytoplasmic protein that belongs to the ThiJ/Pfp1/DJ-1 superfamily of highly conserved proteins that function as protein chaperones, catalases, proteases and kinases. Park7 is widely expressed in the brain as well as in peripheral tissues. It exists as a homodimer that can be localized in the cytoplasm, nucleus and mitochondria. Park7 is a redox-sensitive protein that has been ascribed various functions including that as a redox sensor and antioxidant protein. Mutations in Park7 are associated with a small percentage of hereditary early onset Parkinson’s disease.

Long Name

Parkinson Disease 7

Entrez Gene IDs

11315 (Human); 57320 (Mouse); 117287 (Rat)

Alternate Names

DJ1; DJ-1; DJ1FLJ34360; EC 3.4; FLJ27376; FLJ92274; Oncogene DJ1; Park7; Parkinson disease (autosomal recessive, early onset) 7; Parkinson disease protein 7; protein DJ-1

Product Datasheets

Product Datasheet

COA

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Related Research Areas

Citations for Human Park7/DJ-1 Biotinylated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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Salivary DJ-1 could be an indicator of Parkinson's disease progression
Authors: Wen-Yan Kang, Qiong Yang, Xu-Feng Jiang, Wei Chen, Lin-Yuan Zhang, Xiao-Ying Wang et al.
Frontiers in Aging Neuroscience
DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease.
Authors: Hong, Zhen, Shi, Min, Chung, Kathryn, Quinn, Joseph F, Peskind, Elaine R, Galasko, Douglas, Jankovic, Joseph, Zabetian, Cyrus P, Leverenz, James B, Baird, Geoffrey, Montine, Thomas J, Hancock, Aneeka M, Hwang, Hyejin, Pan, Catherin, Bradner, Joshua, Kang, Un J, Jensen, Poul H, Zhang, Jing
Brain, 2010-02-15;133(0):713-26.
Species: Human
Sample Types: CSF
Applications: Luminex Development