Human Patched 1/PTCH (AAC50550) VersaClone cDNA

Catalog #: RDC1088 Datasheet / COA / SDS

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RDC1088

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Human Patched 1/PTCH (AAC50550) VersaClone cDNA Summary

Specifications

Source

N/A

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species

Human

Product Datasheets

Product Datasheet

COA

SDS

Background: Patched 1/PTCH

Patched homolog 1 (PTC1) is a 170 - 175 kDa member of the Patched family of proteins. It is found on multiple cells types and forms a constitutive, inactivating complex with Smoothened. Upon SHH binding to PTC1, Smoothened is released and initiates downstream signaling.

Mouse PTC1 is a 12 transmembrane, 1434 aa glycoprotein that contains two terminal cytoplasmic domains. Only one mRNA species for PTC1 has been reported in mice. However, two or more splice forms exist, with variation occurring over the first 150 aa of the N-terminus. Over aa 108 - 422, mouse PTC1 shares 97% and 99% aa sequence identity with human and rat PTC1, respectively.

Entrez Gene IDs

5727 (Human); 19206 (Mouse); 89830 (Rat)

Alternate Names

BCNS; BCNSFLJ42602; FLJ26746; HPE7; mes; NBCCS; patched (Drosophila) homolog; Patched 1; patched homolog (Drosophila); patched homolog 1 (Drosophila); patched homolog 1; protein patched homolog 1; PTC; ptc1; PTCH protein +12b; PTCH protein +4'; PTCH protein -10; PTCH; PTCH1; PTCH11