Home / Serpin A3/alpha 1-Antichymotrypsin / Human Serpin A3/ alpha 1-Antichymotrypsin Antibody

Human Serpin A3/ alpha 1-Antichymotrypsin Antibody

Catalog #: MAB1295
5 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB1295
MAB1295-SP
Product Details
Citations (5)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human Serpin A3/ alpha 1-Antichymotrypsin Antibody Summary

Species Reactivity
Human
Specificity
Detects recombinant human (rh)Serpin A3 in direct ELISAs and Western blots. In these formats, this antibody shows 5 - 25% cross-reactivity with rhSerpins A1 and A5 but no cross-reactivity with rhSerpins C1, D1, or F2.
Source
Monoclonal Mouse IgG2A Clone # 213907
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human Serpin A3
aa 26-423
Accession # P01011
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human Serpin A3/ alpha 1-Antichymotrypsin (Catalog # 1295-PI)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Serpin A3/alpha 1-Antichymotrypsin

Serpin A3, also called alpha 1-Antichymotrypsin, is a major constituent of the plaques associated with Alzheimer’s disease. Deficiency in Serpin A3 activity is associated with chronic obstructive pulmonary disease.

Entrez Gene IDs
12 (Human)
Alternate Names
AACTMGC88254; ACTGIG25; alpha 1-Antichymotrypsin; alpha-1-antichymotrypsin; antitrypsin), member 3; Cell growth-inhibiting gene 24/25 protein; growth-inhibiting protein 24; growth-inhibiting protein 25; member 3; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase; serine (or cysteine) proteinase inhibitor, clade A, member 3; Serpin A3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)

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Citations for Human Serpin A3/ alpha 1-Antichymotrypsin Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. NF-?B Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program
    Authors: LM FitzPatric, KE Hawkins, JMKM Delhove, E Fernandez, C Soldati, LF Bullen, A Nohturfft, SN Waddington, DL Medina, JP Bolaños, TR McKay
    Stem Cell Reports, 2018-04-19;0(0):.
  2. Cerebrospinal Fluid Biomarkers of Myeloid and Glial Cell Activation Are Correlated With Multiple Sclerosis Lesional Inflammatory Activity
    Authors: Ruturaj Masvekar, Jonathan Phillips, Mika Komori, Tianxia Wu, Bibiana Bielekova
    Frontiers in Neuroscience
  3. Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis
    Authors: I Lopez-Fabu, M Garcia-Mac, C Buondelmon, O Burmistrov, N Bonora, P Alonso-Bat, B Morant-Fer, C Vicente-Gu, D Jimenez-Bl, R Quintana-C, E Fernandez, J Llop, P Ramos-Cabr, A Sharaireh, M Guevara-Fe, L Fitzpatric, CD Thompton, TR McKay, S Storch, DL Medina, SE Mole, PO Fedichev, A Almeida, JP Bolaños
    Nature Communications, 2022-01-27;13(1):536.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  4. Drug library screen identifies inhibitors of toxic astrogliosis
    Authors: R Masvekar, P Kosa, C Barbour, JL Milstein, B Bielekova
    Multiple sclerosis and related disorders, 2022-01-04;58(0):103499.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Maggot chymotrypsin I from Lucilia sericata is resistant to endogenous wound protease inhibitors.
    Authors: Telford G, Brown AP, Kind A, English JS, Pritchard DI
    Br. J. Dermatol., 2010-11-29;164(1):192-6.
    Species: Human
    Sample Types: Tissue Homogenates
    Applications: Western Blot

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