Human SLPI Biotinylated Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: SLPI
SLPI is a member of the Serpin family and is primarily expressed in secretory glandular epithelial cells. It is found in various secretory fluids and functions as a potent inhibitor of many proteolytic enzymes. SLPI can modulate cell proliferation and has been shown to have anti-inflammatory, anti-viral, and anti-bacterial activities (1, 2).
- Zhang, D. et al. (2002) J. Biol. Chem. 277:29999.
- Taggart, C.C. et al. (2002) J. Biol. Chem. 277:33648.
Product Datasheets
Citations for Human SLPI Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
6
Citations: Showing 1 - 6
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Neutrophils and Activated Macrophages Control Mucosal Immunity by Proteolytic Cleavage of Antileukoproteinase
Authors: Jennifer Vandooren, Pieter Goeminne, Lise Boon, Estefania Ugarte-Berzal, Vasily Rybakin, Paul Proost et al.
Frontiers in Immunology
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Endogenous secretory leukocyte protease inhibitor (SLPI) inhibits microbial-induced monocyte activation
Authors: S Nugteren, Y Simons-Oos, CL Menckeberg, DH Hulleman-v, DJ Lindenberg, JN Samsom
European Journal of Immunology, 2022-12-22;0(0):.
Species: Human
Sample Types: Recombinant Protein, Whole Tissue
Applications: ELISA Detection, IHC -
High expression of secretory leukocyte protease inhibitor (SLPI) in stage III micro-satellite stable colorectal cancer is associated with reduced disease recurrence
Authors: S Nugteren, SH den Uil, PM Delis-van, Y Simons-Oos, DJ Lindenberg, DH van Haafte, HBAC Stockmann, J Sanders, GA Meijer, RJA Fijneman, JN Samsom
Scientific Reports, 2022-07-16;12(1):12174.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Annexin A2 antibodies but not inhibitors of the annexin A2 heterotetramer impair productive HIV-1 infection of macrophages in vitro
Authors: W Martin Kast
Virol. J., 2016-11-18;13(1):187.
Species: Human
Sample Types: Cell Lysates
Applications: ELISA Development (Detection) -
Decreased levels of secretory leucoprotease inhibitor in the pseudomonas-infected cystic fibrosis lung are due to neutrophil elastase degradation.
Authors: Weldon S, McNally P, McElvaney NG, Elborn JS, McAuley DF, Wartelle J, Belaaouaj A, Levine RL, Taggart CC
J. Immunol., 2009-12-15;183(12):8148-56.
Species: Human
Sample Types: BALF
Applications: ELISA Development, Western Blot -
Expression of the immune modulator secretory leukocyte protease inhibitor (SLPI) in colorectal cancer liver metastases and matched primary tumors is associated with a poorer prognosis
Authors: Sandrine Nugteren, Jeroen A.C.M. Goos, Pien M. Delis-van Diemen, Ytje Simons-Oosterhuis, Dicky J. Lindenbergh-Kortleve, Daniëlle H. van Haaften et al.
OncoImmunology
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