Human TM4SF4 PE-conjugated Antibody
Human TM4SF4 PE-conjugated Antibody Summary
Accession # P48230
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data

Detection of TM4SF4 in HT‑29 Human Cell Line by Flow Cytometry. HT-29 human colon adenocarcinoma cell line was stained with Mouse Anti-Human TM4SF4 PE-conjugated Monoclonal Antibody (Catalog # FAB7998P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
Background: TM4SF4
TM4SF4 (Transmembrane 4 L6 Family Member 4), also known as IL-TMP (Intestine and Liver Tetraspanin Membrane Protein), is a distant member of the tetraspanin L6 domain family of molecules. It is expressed at highest levels on non-proliferating villus-associated intestinal epithelia of the jejunum, periportal hepatocytes, and follicle-associated epithelium of the ileum. It is thought to mediate proliferation and adhesion, and is now known to complex with THTR-2 (Thiamine Transporter-2) during the transport of thiamine into expressing cells. Its molecular size is reported at approximately 21 kDa for the unglycosylated form and varies from 25-30 kDa on proliferating cells, to 25-40 kDa on non-proliferating cells. The 202 amino acid (aa) human TM4SF4 contains four transmembrane domains and two potential N-glycosylation sites. The extracellular region of human TM4SF4 shares 72% aa sequence identity with mouse TM4SF4.
Product Datasheets
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