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Human TMEFF1/Tomoregulin-1 Antibody

Catalog #: MAB1919
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
MAB1919
MAB1919-SP
Product Details
Citations (2)
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Summary Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human TMEFF1/Tomoregulin-1 Antibody Summary

Species Reactivity
Human
Specificity
Detects human TMEFF1/Tomoregulin‑1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no  cross-reactivity with recombinant mouse TMEFF1 or recombinant human TMEFF2 is observed.
Source
Monoclonal Mouse IgG2A Clone # 249511
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse myeloma cell line NS0-derived recombinant human TMEFF1/Tomoregulin‑1
Ser40-Thr328
Accession # Q8IYR6
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Applications

Recommended Concentration
Sample
Western Blot
1 µg/mL
Recombinant Human TMEFF1/Tomoregulin‑1

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.5 mg/mL in sterile PBS.
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Shipping
Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TMEFF1/Tomoregulin-1

TMEFF1 (Transmembrane protein with EGF-like and two Follistatin-like domains 1), also known as tomoregulin 1 is a type I transmembrane glycoprotein that contains two follistatin modules and an EGF domain in its extracellular domain, a transmembrane domain and a short cytoplasmic tail. The extracellular domain can be released as a soluble protein. TMEFF1 selectively regulates nodal but not activin signaling through direct binding to the nodal co-receptor, Cripto.

Long Name
Transmembrane Protein with EFG-like and two Follistatin-like Domains
Entrez Gene IDs
8577 (Human); 230157 (Mouse)
Alternate Names
C9orf2; H7365member 1; TMEFF1; Tomoregulin1; Tomoregulin-1; TR-1; Transmembrane protein with EGF-like and one follistatin-like domain; transmembrane protein with EGF-like and two follistatin-like domains 1

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Citations for Human TMEFF1/Tomoregulin-1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. LTBP-2 Has a Single High-Affinity Binding Site for FGF-2 and Blocks FGF-2-Induced Cell Proliferation.
    Authors: Menz C, Parsi M, Adams J, Sideek M, Kopecki Z, Cowin A, Gibson M
    PLoS ONE, 2015-08-11;10(8):e0135577.
  2. Gene expression profiling and real-time PCR analyses identify novel potential cancer-testis antigens in multiple myeloma.
    Authors: Condomines M, Hose D, Reme T, Requirand G, Hundemer M, Schoenhals M, Goldschmidt H, Klein B
    J. Immunol., 2009-06-19;183(2):832-40.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot

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