Human TRAIL R3/TNFRSF10C APC-conjugated Antibody Summary
Met1-Ala221
Accession # O14798
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of TRAIL R3/TNFRSF10C in Human PBMC Monocytes by Flow Cytometry. Human peripheral blood mononuclear cell (PBMC) Monocytes were stained with Mouse Anti-Human TRAIL R3/TNFRSF10C APC-conjugated Monoclonal Antibody (Catalog # FAB6302A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Detection of TRAIL R3/TNFRSF10C in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Mouse Anti-Human TRAIL R3/TNFRSF10C APC-conjugated Monoclonal Antibody (Catalog # FAB6302A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TRAIL R3/TNFRSF10C
Human TRAIL R3, also known as DcR1 (Decoy Receptor 1), LIT, and TRID, is a glycosyl-phosphatidylinositol-linked membrane protein which binds TRAIL (Apo2 Ligand) with high affinity. In the new TNF superfamily nomenclature, TRAIL R3 is referred to as TNFRSF10C. TRAIL R3 has the TRAIL-binding extracellular cysteine-rich domains but lacks the intracellular signalling domain. As a result, binding of TRAIL to TRAIL R3 does not transduce an apoptosis signal. Expression of TRAIL R3 has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis. A second TRAIL decoy receptor, which binds TRAIL with high-affinity but antagonizes TRAIL-induced apoptosis, named TRAIL R4, DcR2 or TRUNDD, has also been reported. The human soluble TRAIL R3/Fc chimera neutralizes the ability of TRAIL to induce apoptosis.
Product Datasheets
Citations for Human TRAIL R3/TNFRSF10C APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Targeting of CD133+ Cancer Stem Cells by Mesenchymal Stem Cell Expressing TRAIL Reveals a Prospective Role of Apoptotic Gene Regulation in Non-Small Cell Lung Cancer
Authors: KS Fakiruddin, MN Lim, N Nordin, R Rosli, Z Zakaria, S Abdullah
Cancers (Basel), 2019-08-28;11(9):.
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Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells
Authors: A Willms, H Schittek, S Rahn, J Sosna, U Mert, D Adam, A Trauzold
PLoS ONE, 2019-04-04;14(4):e0214847.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Impact of Extracellular pH on Apoptotic and Non-Apoptotic TRAIL-Induced Signaling in Pancreatic Ductal Adenocarcinoma Cells
Authors: Sofie Hagelund, Anna Trauzold
Frontiers in Cell and Developmental Biology
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