Home / TRAILR4/TNFRSF10D / Human TRAILR4/TNFRSF10D PE-conjugated Antibody

Human TRAILR4/TNFRSF10D PE-conjugated Antibody

Catalog #: FAB633P
19 Citations Datasheet / COA / SDS
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FAB633P
Detection of TRAIL R4/TNFRSF10D in Human Blood Granulocytes by Flow Cytometry.
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Citations (19)
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Human TRAILR4/TNFRSF10D PE-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human TRAIL R4/TNFRSF10D in ELISAs and Western blots. In sandwich immunoassays, less than 5% cross-reactivity with recombinant human (rh) TRAIL R1, rhTRAIL R2, TRAIL R3, rhTRAIL, rhTNF‑ alpha, and rhTNF-beta is observed.
Source
Monoclonal Mouse IgG1 Clone # 104918
Purification
Protein A or G purified from ascites
Immunogen
Mouse myeloma cell line NS0-derived recombinant human TRAIL R4/TNFRSF10D
Ala56-His211
Accession # Q9UBN6
Formulation
Supplied in a saline solution containing BSA and Sodium Azide.
Label
Phycoerythrin (Excitation= 488 nm, Emission= 565-605 nm)

Applications

Recommended Concentration
Sample
Flow Cytometry
10 µL/106 cells
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry Detection of TRAIL R4/TNFRSF10D antibody in Human Blood Granulocytes antibody by Flow Cytometry. View Larger

Detection of TRAIL R4/TNFRSF10D in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Mouse Anti-Human TRAIL R4/TNFRSF10D PE-conjugated Monoclonal Antibody (Catalog # FAB633P, filled histogram) or isotype control antibody (Catalog # IC002P, open histogram). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.

Background: TRAILR4/TNFRSF10D

Human TRAIL R4, also called Decoy Receptor 2 (DcR2) and TRUNND (TRAIL Receptor with a Truncated Death Domain), is a type I, TNF R family transmembrane protein, which is a receptor for TRAIL (APO2 Ligand). In the TNF superfamily nomenclature, TRAIL R4 is designated as TNFRSF10D. TRAIL R4 is unique among the TRAIL receptors in that its cytoplasmic domain contains a truncated consensus death domain motif. Binding of TRAIL R4 does not result in an apoptotic signal. Overexpression of TRAIL R4 can protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-mediated apoptosis. The human soluble TRAIL R4/Fc chimera neutralizes the ability of TRAIL to induce apoptosis.

References
  1. Griffith, T.S. et al. (1998) Curr. Opin. Immunol. 10:559.
  2. Pan, G. et al. (1998) FEBS lett 424:41.
  3. Marsters, S.A. et al. (1997) Cur. Biol. 7:1003.
  4. Degli-Esposti, M.A. et al. (1997) Immunity 7:813.
Long Name
TRAIL Receptor 4
Entrez Gene IDs
8793 (Human)
Alternate Names
CD264 antigen; CD264; DcR2; DCR2decoy with truncated death domain; Decoy receptor 2; TNF receptor-related receptor for TRAIL; TNF-related apoptosis-inducing ligand receptor 4; TNFRSF10D; TRAIL R4; TRAILR4; TRAIL-R4; TRAILR4TRAIL receptor 4; TRUNDDTRAIL receptor with a truncated death domain; tumor necrosis factor receptor superfamily member 10D; tumor necrosis factor receptor superfamily, member 10d, decoy with truncateddeath domain

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Citations for Human TRAILR4/TNFRSF10D PE-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

19 Citations: Showing 1 - 10
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  1. Oxaliplatin resistance in colorectal cancer enhances TRAIL sensitivity via death receptor 4 upregulation and lipid raft localization
    Authors: JD Greenlee, M Lopez-Cave, N Ortiz-Oter, K Liu, T Subramania, B Cagir, MR King
    Elife, 2021-08-03;10(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  2. Alternol Sensitizes Renal Carcinoma Cells to TRAIL-Induced Apoptosis
    Authors: Yu Ren, Xue Wang, Shuaishuai Huang, Yangkai Xu, Guobin Weng, Rui Yu
    Frontiers in Pharmacology
  3. Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells
    Authors: EB Jo, YS Lee, H Lee, JB Park, H Park, YL Choi, D Hong, SJ Kim
    BMC Cancer, 2019-05-24;19(1):496.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  4. Decoy TRAIL receptor CD264: a cell surface marker of cellular aging for human bone marrow-derived mesenchymal stem cells
    Authors: SD Madsen, KC Russell, HA Tucker, J Glowacki, BA Bunnell, KC O'Connor
    Stem Cell Res Ther, 2017-09-29;8(1):201.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  5. Targeting Apoptotic Activity Against Prostate Cancer Stem Cells
    Authors: D Jaworska, E Szliszka
    Int J Mol Sci, 2017-07-29;18(8):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  6. TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis
    Authors: HD Singh, I Otano, K Rombouts, KP Singh, D Peppa, US Gill, K Böttcher, PTF Kennedy, J Oben, M Pinzani, H Walczak, G Fusai, WMC Rosenberg, MK Maini
    Sci Rep, 2017-07-17;7(1):5514.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  7. Soluble TRAIL is present at high concentrations in seminal plasma and promotes spermatozoa survival
    Authors: Giorgio Zauli, Claudio Celeghini, Lorenzo Monasta, Monica Martinelli, Stefania Luppi, Arianna Gonelli et al.
    REPRODUCTION
  8. TRAIL-engineered bone marrow-derived mesenchymal stem cells: TRAIL expression and cytotoxic effects on C6 glioma cells.
    Authors: Tang X, Lu J, Tu H, Huang K, Fu R, Cao G, Huang M, Cheng L, Dai L, Zhang L
    Anticancer Res, 2014-02-01;34(2):729-34.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  9. CD70-restricted specific activation of TRAILR1 or TRAILR2 using scFv-targeted TRAIL mutants
    Authors: J Trebing, M El-Mesery, V Schäfer, D Weisenberger, D Siegmund, K Silence et al.
    Cell Death & Disease
  10. Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma.
    Authors: Kim, Seong Mu, Woo, Ji Sun, Jeong, Chang Hy, Ryu, Chung He, Jang, Jae-Deog, Jeun, Sin-Soo
    Stem Cells Transl Med, 2014-01-16;3(2):172-82.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  11. Epigonal Conditioned Media from Bonnethead Shark, Sphyrna tiburo, Induces Apoptosis in a T-Cell Leukemia Cell Line, Jurkat E6-1
    Authors: Catherine J. Walsh, Carl A. Luer, Jennifer E. Yordy, Theresa Cantu, Jodi Miedema, Stephanie R. Leggett et al.
    Marine Drugs
  12. Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia.
    Authors: Gojo I, Tan M, Fang H, Sadowska M, Lapidus R, Baer M, Carrier F, Beumer J, Anyang B, Srivastava R, Espinoza-Delgado I, Ross D
    Clin Cancer Res, 2013-02-12;19(7):1838-51.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: Flow Cytometry
  13. TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity.
    Authors: Kalb ML, Glaser A, Stary G, Koszik F, Stingl G
    J. Immunol., 2012-01-09;188(4):1583-91.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  14. Cisplatin sensitizes human hepatocellular carcinoma cells, but not hepatocytes and mesenchymal stem cells, to TRAIL within a therapeutic window partially depending on the upregulation of DR5
    Authors: Bo Zhang, Hong Shan, Dan Li, Zheng-Ran Li, Kang-Shun Zhu, Zai-Bo Jiang et al.
    Oncology Reports
  15. Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients.
    Authors: Stary G, Klein I, Kohlhofer S, Koszik F, Scherzer T, Mullauer L, Quendler H, Kohrgruber N, Stingl G
    Blood, 2009-08-18;114(18):3854-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  16. Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma.
    Authors: Kim SM, Lim JY, Park SI, Jeong CH, Oh JH, Jeong M, Oh W, Park SH, Sung YC, Jeun SS
    Cancer Res., 2008-12-01;68(23):9614-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  17. Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells.
    Authors: Secchiero P, Melloni E, Corallini F, Beltrami AP, Alviano F, Milani D, D'Aurizio F, di Iasio MG, Cesselli D, Bagnara GP, Zauli G
    Stem Cells, 2008-09-04;26(11):2955-63.
    Species: Human
    Sample Types: Whole Cells
    Applications: Flow Cytometry
  18. Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage.
    Authors: Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy PT, Lampertico P, Das A, Lopes AR, Borrow P, Williams K, Humphreys E, Afford S, Adams DH, Bertoletti A, Maini MK
    J. Exp. Med., 2007-03-12;204(3):667-80.
    Species: Human
    Sample Types: Serum
    Applications: Flow Cytometry
  19. Survival of aging CD264+ and CD264- populations of human bone marrow mesenchymal stem cells is independent of colony-forming efficiency
    Authors: Madsen SD, Jones SH, Tucker HA et al.
    Biotechnol. Bioeng.

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