Human TR beta 1/NR1A2 Antibody

Catalog #: PP-H3825A-00 Datasheet / COA / SDS

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PP-H3825A-00

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Human TR beta 1/NR1A2 Antibody Summary

Species Reactivity

Human

Specificity

This antibody specifically recognizes human TR beta 1, and does not cross-react with human TR beta 2 or human TR alpha. Not yet tested in other species.

Source

Monoclonal Mouse IgG_2A Clone # H3825A

Purification

Protein A or G purified from hybridoma culture supernatant

Immunogen

Recombinant human TR beta 1/NR1A2
aa 2-100

Formulation

A liquid formulation in physiologic saline with 0.1% NaN₃.

Label

Unconjugated

Applications

Recommended Concentration

Sample

Western Blot

This antibody can be used at 1 μg/mL under reducing conditions with the appropriate secondary reagents to detect human TR beta 1.

Immunoprecipitation

Optimal dilutions should be determined by each laboratory.

Direct ELISA

This antibody can be used at 0.1 μg/mL with the appropriate secondary reagents to detect human TR beta 1.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

This antibody is stable for greater than six months when held at -20 °C in a manual defrost freezer or at -70 °C. Upon thawing, the antibody can be stored at 2-8 °C for at least 1 month without detectable loss of activity. Avoid repeated freeze-thaw cycles.

Background: TR beta 1/NR1A2

Thyroid Hormone Receptor beta (TR beta, THRB; NR1A2) is a member of the Nuclear Hormone Receptor superfamily. The ligands for TR beta are the thyroid hormones, which exist in two forms: T4 (3,5,3',5'-tetraiodo-L-thyronine) and T3 (3,5,3'-tri-iodo-L-thyronine). TR beta plays critical roles in the differentiation, growth, metabolism and physiology of a wide variety of tissues. The major partners of TRs are the Retinoid X Receptors (RXRs), which strongly enhance their ability to bind to specific DNA sequences and contribute to the specificity of TR.

Long Name

Thyroid Hormone Receptor beta 1

Entrez Gene IDs

7068 (Human)

Alternate Names

avian erythroblastic leukemia viral (v-erb-a) oncogene homolog 2; c-erbA-2; c-erbA-beta; ERBA2MGC126109; ERBA-BETA; GRTH; MGC126110; NR1A2; NR1A2thyroid hormone receptor, beta (avian erythroblastic leukemia viral (v-erb-a)oncogene homolog 2); Nuclear receptor subfamily 1 group A member 2; oncogene ERBA2; PRTH; THR1pituitary resistance to thyroid hormone; THRB; THRB1; THRB2; thyroid hormone receptor beta 1; thyroid hormone receptor beta; thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a)oncogene homolog 2, avian); TR beta 1; v-ErbA2