Human TROP-2 PE-conjugated Antibody Summary
His27-Thr274
Accession # P09758
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of TROP‑2 in PC‑3 Human Cell Line by Flow Cytometry. PC-3 human prostate cancer cell line was stained with Mouse Anti-Human TROP-2 PE-conjugated Monoclonal Antibody (Catalog # FAB650P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TROP-2
Human TROP-2, also known as Tumor Associated Calcium Signal Transducer 2 (TACSTD2), GA733-1, gp50 and T16, is a type I cell surface glycoprotein that is highly expressed on human carcinomas. It was originally identified as an antigen present on human gastrointestinal tumors and is the second of two members of this family. The other family member is GA733-2, also called EpCAM, TROP-1, 17-1A, gp40 and KSA. The TROP-2 gene is unique in that it contains no introns. A study of these two genes suggested that TROP-2 was the result of a retroposition of the EpCAM gene. TROP-2 and EpCAM share approximately 49% amino acid identity and approximately 67% similarity. Human and mouse TROP-2 share 87% similarity. The human TROP-2 protein consists of a putative 26 amino acid (aa) signal sequence, a 248 aa extracellular domain, a 23 aa transmembrane region and a 26 aa cytoplasmic domain. TROP-2 is capable of transducing an intracellular calcium signal and may play a role in tumor growth. It also has adhesive functions.
- Linnenbach, A.J. et al. (1989) Proc. Natl. Acad. Sci. USA 86:27.
- Linnenbach, A.J. et al. (1993) Mol. Cell. Biol. 13:1507.
- Fornaro, M. et al. (1995) Int. J. Cancer 62:610.
- Ripani, E. et al. (1998) Int. J. Cancer 76:671.
- El Sewedy, T. et al. (1998) Int. J. Cancer 75:324.
Product Datasheets
Citations for Human TROP-2 PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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A rationally designed ICAM1 antibody drug conjugate eradicates late-stage and refractory triple-negative breast tumors in vivo
Authors: Guo, P;Huang, J;Zhu, B;Huang, AC;Jiang, L;Fang, J;Moses, MA;
Science advances
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry, ICC -
Purification and direct transformation of epithelial progenitor cells from primary human prostate
Authors: Andrew S. Goldstein, Justin M. Drake, Daina L. Burnes, David S. Finley, Hong Zhang, Robert E. Reiter et al.
Nature Protocols
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Detection of TROP2 on A-431 epidermoid carcinoma cell line. A-431 cells were treated with Human TROP-2 PE-conjugated Antibody (catalog # FAB650P) or PE-conjugated mouse IgG2a isotype control (RED).
