Human TSHR (P16473) VersaClone cDNA

Catalog #: RDC0189 Datasheet / COA / SDS

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RDC0189

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Human TSHR (P16473) VersaClone cDNA Summary

Specifications

Shipping Conditions

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Storage

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Species

Human

Product Datasheets

Product Datasheet

COA

SDS

Background: TSHR

TSHR (Thyroid Stimulating Hormone Receptor) confers responsiveness to the endocrine hormones Thyrotropin/TSH and Thyrostimulin. TSH is produced by the anterior pituitary and triggers the thyroid gland to release thyroxine (T4). T4 is then converted to triiodothyronine (T3) which exerts wide-ranging effects on growth and metabolism. The heterodimeric TSHR is primarily expressed by epithelial cells of the thyroid (thyrocytes). TSHR is the dominant target of autoreactive agonistic antibodies in Graves’ disease but is a more rare target in Hashimoto’s thyroiditis. The activation of TSHR in brown adipose tissue can trigger the upregulation of UCP-1 as well as thermogenesis.

Long Name

Thyroid Stimulating Hormone Receptor

Entrez Gene IDs

7253 (Human); 22095 (Mouse)

Alternate Names

CHNG1; LGR3; LGR3hTSHR-I; MGC75129; seven transmembrane helix receptor; thyroid stimulating hormone receptor; Thyroid-stimulating hormone receptor; thyrotropin receptor; thyrotropin receptor-I, hTSHR-I; TSH R; TSHR; TSH-R