Human VSTM5 Alexa Fluor® 700-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: VSTM5

V-set and transmembrane domain-containing protein 5 (VSTM5) is a cell-adhesion like molecule that belongs to the Ig superfamily.  This molecule is expressed in hippocampal neurons.  It regulates neuronal morphology by promoting dendritic protrusions that develop into dendritic spines.  VSTM5 is a novel factor involved in the modulation of the neuronal membrane and a critical element in normal neuronal circuit formation.  It is one of the target genes responsible for variations in patient responses to treatments for major depressive disorder. Overexpression of VSTM5 in utero delays neuronal migration and induces multiple branches in leading processes during corticogenesis.  Glycosylation at individual N-linked glycosylation sites (Asn43, Asn87, Asn101, and Asn108) not only play essential roles in surface expression of VSTM5 but also in the formation of neuronal dendritic filopodia.

Product Datasheets

Product Specific Notices

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Related Research Areas

• Synaptic Adhesion Molecules