IC 87201
Discontinued Product
Chemical Name: 2-[(1H-Benzotriazol-6-ylamino)methyl]-4,6-dichlorophenol
Purity: ≥99%
Biological Activity
IC 87201 is an inhibits binding of the NMDA receptor postsynaptic density protein 95 kDa (PSD95) to nNOS (EC50 = 23.94 μM), while not affecting the PSD95-ErbB4 interaction. Inhibits glutamate-induced cell death in cultured cortical neurons. Exhibits antinociceptive effects in inflammatory pain models in vivo. Also exhibits antidepressant-like activitiy in animal models.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice.
Doucet et al.
Neuropsychopharmacology., 2013;38:1575 -
Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics.
Lee et al.
Neuropharmacology., 2015;97:464 -
Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents.
Florio et al.
Br.J.Pharmacol., 2009;158:494
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