IEM 1925 dihydrobromide

Biological Activity

IEM 1925 dihydrobromide is a voltage- and use-dependent open-channel antagonist of AMPA receptors. Selective between subtypes; blocks GluA2 subunit-lacking receptors more potently than GluA2-containing receptors (K_D for GluA2-containing AMPAR is 210 times higher at -80 mV). More potent than IEM 1460 (Cat. No. 1636) and IEM 1754 due to a slower unblocking rate. Alleviates inflammatory pain in a rat model of peripheral inflammation.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Voltage-dependent block of native AMPA receptor channels by dicationic compounds.
   Tikhonov et al.
   Br.J.Pharmacol., 2000;129:265
2. Inhibition of spinal Ca²⁺-permeable AMPA receptors with dicationic compounds alleviates persistent inflammatory pain without adverse effects.
   Kopach et al.
   Front.Cell Neurosci., 2016;10

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