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Iloprost

Catalog #: 2038
2 Citations Datasheet / COA / SDS

Discontinued Product

2038 has been discontinued.
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Iloprost | CAS No. 78919-13-8 | Prostanoid Receptor Agonists
1 Image
Description: Prostacyclin (PGI2) analog
Alternative Names: ZK 36374

Chemical Name: (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]pentanoic acid

Purity: ≥97%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Iloprost is a prostacyclin (PGI2) analog that binds with high affinity to IP, EP1 and EP3 receptors (Ki values are 11, 11, 56, 284, 619, 1035, 1870 and 6487 nM for IP, EP1, EP3, EP4, FP, DP, EP2 and TP receptors respectively). Inhibits platelet aggregation induced by collagen, thrombin and ADP (IC50 values are 0.24, 0.71 and 1.07 nM respectively).

Technical Data

M.Wt:
360.49
Formula:
C22H32O4
Solubility:
Soluble in methyl acetate (supplied pre-dissolved - 5mg/ml)
Purity:
≥97%
Storage:
Store at -20°C
CAS No:
78919-13-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Novel mode of action of iloprost: in vitro down-regulaton of endothelial cell adhesion molecules.
    Della Bella et al.
    Prostaglandins Other Lipid Mediat., 2001;65:73
  2. The utilization of recombinant prostanoid receptors to determine the affinities and selectivities of prostaglandins and related analogs.
    Abramovitz et al.
    Biochim.Biophys.Acta, 2000;1483:285
  3. The antiplatelet and cardiovascular actions of a new carbacyclin derivative (ZK 36 374) - equipotent to PGI2 in vitro.
    Schror et al.
    Naunyn-Schmied.Arch.Pharmacol., 1981;316:252

Product Datasheets

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Citations for Iloprost

The citations listed below are publications that use Tocris products. Selected citations for Iloprost include:

2 Citations: Showing 1 - 2

  1. A human platelet calcium calculator trained by pairwise agonist scanning.
    Authors: Lee and Diamond
    Nat Commun  2015;11:e1004118
  2. Multiscale prediction of patient-specific platelet function under flow.
    Authors: Flamm Et al.
    Blood  2012;120:190

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