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Istradefylline

Catalog #: 5147
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5147/10
5147/50
Istradefylline | CAS No. 155270-99-8 | Adenosine A2a Receptor Antagonists
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Description: Potent and selective A2A antagonist
Alternative Names: KW-6002

Chemical Name: 8-[(1E)-2-(2-(3,4-Dimethoxyphenyl)ethenyl]-1,3-diethyl-3,7-dihydro-7-methyl-1H-purine-2,6-dione

Purity: ≥99%

Product Details
Citations (4)
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Biological Activity

Istradefylline is a potent and selective adenosine A2A receptor antagonist (Ki values are 2.2 and 150 nM for A2A and A1 receptors respectively). Anticataleptic and antiparkinson agent; reverses drug-induced motor dysfunction in animal models.

Technical Data

M.Wt:
384.43
Formula:
C20H24N4O4
Solubility:
Soluble to 20 mM in DMSO
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
155270-99-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Adenosine A2A antagonists with potent anti-cataleptic activity.
    Shimada et al.
    Bioorg.Med.Chem.Lett., 1997;7:2349
  2. Adenosine A2A receptors modify motor function in MPTP-treated common marmosets.
    Kanda et al.
    Neuroreport, 1998;9:2857
  3. Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by rese. or MPTP.
    Shiozaki et al.
    Psychopharmacology, 1999;147:90

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Citations for Istradefylline

The citations listed below are publications that use Tocris products. Selected citations for Istradefylline include:

4 Citations: Showing 1 - 4

  1. Cannabis sativa terpenes are cannabimimetic and selectively enhance cannabinoid activity.
    Authors: John M Et al.
    Sci Rep  2021;11:8232
  2. Istradefylline reduces memory deficits in aging mice with amyloid pathology.
    Authors: Orr Et al.
    Neurobiol Dis  2018;110:29
  3. Structures of Human A1 and A2A Adenosine Receptors with Xanthines Reveal Determinants of Selectivity.
    Authors: Cheng Et al.
    Structure  2017;25:1275
  4. On the role of A2A and D2 receptors in control of cocaine and food-seeking behaviors in rats.
    Authors: Wydra Et al.
    PLoS One  2015;232:1767

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