ISX 9

Biological Activity

ISX 9 is a neurogenic agent. Mediates neuroD reporter gene induction via activation of Ca²⁺ influx; increases expression of neurogenic differentiation 1 (NeuroD1) transcription factor. Induces neuronal differentiation in human cortical neuronal cells (HCN), adult mouse whole brain (MWB) and subventricular zone (SVZ) progenitors. ISX 9 is also shown to induce cardiomyogenic differentiation of Notch-activated epicardium-derived cells in vitro. When used in combination with other small molecules, ISX 9 directs differentiation of pancreatic progenitors towards β cells.

ISX 9 synthesized to Ancillary Material Grade also available.

For more information about how ISX 9 may be used, see our protocol: Transdifferentiating Fibroblasts into Neurons.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Targeting native adult heart progenitors with cardiogenic small molecules.
   Russell et al.
   ACS Chem.Biol., 2012;7:1067
2. Small-molecule activation of neuronal cell fate.
   Schneider et al.
   Nat.Chem.Biol, 2008;4:408
3. Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression.
   Zhang et al.
   Differentiation, 2011;81:233
4. A small molecule differentiation inducer increases Ins production by pancreatic β cells.
   Dioum et al.
   Proc.Natl.Acad.Sci.U.S.A., 2011;108:20713
5. ISX-9 manipulates endocrine progenitor fate revealing conserved intestinal lineages in mouse and human organoids
   A Tsakmaki, P Fonseca Pe, P Pavlidis, B Hayee, GA Bewick
   Mol Metab, 2020;34(0):157-173.

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