Itraconazole
Chemical Name: 4-[4-[4-[4-[[2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one
Purity: ≥99%
Biological Activity
Itraconazole is a SMO antagonist (IC50 = 690 nM); acts at different binding site to cyclopamine (Cat. No. 1623). Also cytochrome p450 inhibitor (IC50 = 16-26 nM). Inhibits cell cycle at G1 phase in vitro and blocks angiogenesis in vivo (IC50 = 160 nM). Antifungal.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth.
Kim et al.
Cancer Cell, 2010;17:388 -
Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists.
Kim et al.
Cancer Cell, 2013;23:23 -
Inhibition of angiogenesis by the antifungal drug itracon.
Chong et al.
ACS Chem.Biol., 2007;2:263 -
Repurposing the clinically efficacious antifungal agent itracon. as an anticancer chemotherapeutic.
Pace et al.
J.Med.Chem., 2016;59:3635
Product Datasheets
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Citations for Itraconazole
The citations listed below are publications that use Tocris products. Selected citations for Itraconazole include:
2 Citations: Showing 1 - 2
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Nucleoli in epithelial cell collectives respond to tumorigenic, spatial, and mechanical cues.
Authors: Amit Et al.
Mol Biol Cell 2022;33:br19
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Optimized Vivid-derived Magnets photodimerizers for subcellular optogenetics in mammalian cells.
Authors: Jonathan S Et al.
Elife 2020;9
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