Ivermectin
Chemical Name: 22,23-Dihydroavermectin B1
Purity: ≥96%
Biological Activity
Ivermectin is a positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor and the purinergic P2X4 receptor. Antihelmintic and antiviral. Also modulates glutamate- and GABA-activated chloride channels. Potentiates glycine-gated currents at low concentrations (30 nM). Inhibits replication of SARS-CoV-2 in vitro (IC50 ~ 2μM).This product is composed of both Ivermectin B1a (>90%) and Ivermectin B1b.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
- This product is composed of both Ivermectin B1a (>90%) and Ivermectin B1b
- Deuterated analog also available
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
Allosteric control of gating and kinetics at P2X4 receptor channels.
Khakh et al.
J.Neurosci., 1999;19:7289 -
Ivermectin: a positive allosteric effector of the α7 neuronal nicotinic acetylcholine receptor.
Krause et al.
Mol.Pharmacol., 1998;53:283 -
Ivermectin, an unconventional agonist of the glycine receptor chloride channel.
Shan et al.
J.Biol.Chem., 2001;276:12556 -
Activation of rat recombinant α1β2γ2S GABAA receptor by the insecticide iverm.
Adelsberger et al.
Eur.J.Pharmacol., 2000;394:163 -
The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro.
Caly et al.
Antiviral Res., 2020;178
Product Datasheets
Reconstitution Calculator
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Citations for Ivermectin
The citations listed below are publications that use Tocris products. Selected citations for Ivermectin include:
5 Citations: Showing 1 - 5
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Ginsenosides Act As Positive Modulators of P2X4 Receptors.
Authors: Dhuna Et al.
Mol Pharmacol 2019;95:210
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A biofidelic 3D culture model to study the development of brain cellular systems.
Authors: Ren Et al.
Pharmacol Res Perspect 2016;6:24953
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Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells.
Authors: Dolma Et al.
Cancer Cell 2016;29:859
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Natural compounds with P2X7 receptor-modulating properties.
Authors: Fischer Et al.
Purinergic Signal 2013;10:313
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Positive allosteric modulation by iverm. of human but not murine P2X7 receptors.
Authors: Nörenberg Et al.
Br J Pharmacol 2012;167:48
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