(±)-J 113397
Chemical Name: (±)-1-[(3R*,4R*)-1-(Cyclooctylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one
Purity: ≥98%
Biological Activity
(±)-J 113397 is a potent and selective NOP receptor antagonist (IC50 values are 2.3, 1400, 2200 and > 10000 nM for NOP, κ, μ and δ-opioid receptors respectively). Inhibits nociceptin/orphanin FQ-induced hyperalgesia in the mouse tail-flick test.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
-
Discovery of the first potent and selective small molecule opioid receptor-like (ORL1) antagonist: 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397).
Kawamoto et al.
J.Med.Chem., 1999;42:5061 -
In vitro and in vivo pharmacological characterization of J-113397, a potent and selective non-peptidyl ORL1 receptor antagonist.
Ozaki et al.
Eur.J.Pharmacol., 2000;402:45 -
The nociceptin/orphanin FQ receptor antagonist J-113397 and L-DOPA additively attenuate experimental Parkinsonism through overinhibition of nigrothalamic pathway.
Marti et al.
J.Neurosci., 2007;27:1297
Product Datasheets
Reconstitution Calculator
Molarity Calculator
Citation for (±)-J 113397
The citations listed below are publications that use Tocris products. Selected citations for (±)-J 113397 include:
1 Citation: Showing 1 - 1
-
Pharmacological mechanisms underlying the antinociceptive and tolerance effects of the 6,14-bridged oripavine compound 030418.
Authors: Wen Et al.
Acta Pharmacol Sin 2011;32:1215
FAQs
No product specific FAQs exist for this product, however you may
View all Small Molecule FAQsReviews for (±)-J 113397
There are currently no reviews for this product. Be the first to review (±)-J 113397 and earn rewards!
Have you used (±)-J 113397?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
