Jingzhaotoxin III

Catalog #: 4913 Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
4913/100U

1 Image

Description: Selective NaV1.5 channel blocker

Purity: ≥95%

View All Products for Voltage-gated Sodium Channel Blockers

Product Details

Reviews

Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Jingzhaotoxin III is a selective blocker of Na_V1.5 channels (IC₅₀ = 348 nM); displays no effect on other isoforms, including Na_V1.2, Na_V1.4, Na_V1.6 and Na_V1.7. Thought to inhibit sodium channel activation by binding to the Na_V1.5 S3-S4 linker of domain II. Selectively inhibits the activation of cardiac sodium channels, but has no effect on sodium channels in dorsal root ganglion neurons.

Technical Data

M.Wt:

3919.5

Formula:

C₁₇₄H₂₄₁N₄₇O₄₆S₆

Sequence:

DGECGGFWWKCGRGKPPCCKGYACSKTWGWCAVEAP

(Modifications: Disulfide bridges: 4-19, 11-24, 18-31)

Solubility:

Soluble to 1 mg/ml in water

Purity:

≥95%

Storage:

Store at -20°C

CAS No:

925463-91-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

Jingzhaotoxin-III, a novel spider toxin inhibiting activation of sodium channel in rat cardiac myocytes.
Xiao et al.
J.Biol.Chem., 2004;279:26220
Molecular basis of the tarantula toxin jingzhaotoxin-III (β-TRTX-Cj1α) interacting with voltage sensors in sodium channel subtype Nav1.5.
Rong et al.
FASEB J., 2011;25:3177

Product Datasheets

COA view current batch

Or select another batch:

View Batch

SDS

Reconstitution Calculator

Molarity Calculator

Reconstitution Calculator

Molarity Calculator

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Peptide FAQs

Reviews for Jingzhaotoxin III

There are currently no reviews for this product. Be the first to review Jingzhaotoxin III and earn rewards!

Have you used Jingzhaotoxin III?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.