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JNJ 55511118

Catalog #: 6278
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
6278/25
6278/5
JNJ 55511118 | CAS No. 2036081-86-2 | AMPA Receptor Modulators
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Description: High affinity and selective negative modulator of AMPA receptors containing TARP-γ8

Chemical Name: 5-[2-Chloro-6-(trifluoromethoxy)phenyl]-1,3-dihydro-2H-benzimidazol-2-one

Purity: ≥98%

Product Details
Citations (2)
Reviews
Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

JNJ 55511118 is a high affinity and selective negative modulator of AMPA receptors containing TARP-γ8 (Ki = 26 nM). Exhibits <50% binding against a panel of 52 receptors, ion channels and transporters (except 5HT2B and melatonin receptors 78% and 57%, respectively). Also displays minimal activity against other TARP-less AMPARs and AMPARs coexpressed with other TARPs or CNIH2. It reduces alcohol self-administration in a mouse models of chronic drinking. Orally bioavailable and brain penetrant. Anticonvulsant.

Technical Data

M.Wt:
328.67
Formula:
C14H8ClF3N2O2
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
2036081-86-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of Janssen Pharmaceutica N.V.

Product Datasheets

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Citations for JNJ 55511118

The citations listed below are publications that use Tocris products. Selected citations for JNJ 55511118 include:

2 Citations: Showing 1 - 2

  1. NMDAR-dependent presynaptic homeostasis in adult hippocampus: Synapse growth and cross-modal inhibitory plasticity.
    Authors: Richard D Et al.
    Neuron  2022;110:3302-3317.e7
  2. Inhibition of AMPA receptors (AMPARs) containing transmembrane AMPAR regulatory protein γ-8 with JNJ-55511118 shows preclinical efficacy in reducing chronic repetitive alcohol self-administration.
    Authors: Hoffman Et al.
    Alcohol Clin.Exp.Res.  2021;45:1424

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