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JNJ 63533054

Catalog #: 5666
1 Citation Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5666/10
5666/50
JNJ 63533054 | CAS No. 1802326-66-4 | Orphan 7-TM Receptor Agonists
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Description: Potent and selective GPR139 agonist

Chemical Name: 3-Chloro-N-[2-oxo-2-[[(1S)-1-phenylethyl]amino]ethyl]benzamide

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

JNJ 63533054 is a potent and selective GPR139 agonist (EC50 = 16 nM). Selective for GPR139 over a panel of GPCRs, ion channels and transporters, including GPR142. Brain and cell penetrant. Orally bioavailable.

Technical Data

M.Wt:
316.78
Formula:
C17H17ClN2O2
Solubility:
Soluble to 100 mM in DMSO and to 20 mM in ethanol
Purity:
≥98%
Storage:
Store at RT
CAS No:
1802326-66-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Identification and SAR of glycine benzamides as potent agonists for the GPR139 receptor.
    Dvorak et al.
    ACS Med.Chem.Lett., 2015;6:1015

Product Datasheets

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Citation for JNJ 63533054

The citations listed below are publications that use Tocris products. Selected citations for JNJ 63533054 include:

1 Citation: Showing 1 - 1

  1. Gene-environment interactions mediate stress susceptibility and resilience through the CaMKIIβ/TARPγ-8/AMPAR pathway.
    Authors: Susumu Et al.
    iScience  2021;24:102504

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